RNA as a target and an initiator of post-transcriptional gene silencing in trangenic plants

Plant Molecular Biology

Volumn 32, Issue 1-2, 1996, Pages 79-88

  Baulcombe, David C ^a  

^a SAINSBURY LABORATORY   (United Kingdom)

Author keywords

antisense RNA; cosuppression; DNA methylation; RNA degradation; RNA polymerase; RNA dependent; virus resistance

Indexed keywords

EID: 0030267493     PISSN: 01674412     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00039378     Document Type: Article

References (56)

1. Angenent GC, Franken J, Busscher M, Weiss D, van Tunen AJ: Co-suppression of the petunia homeotic gene fbp2 affects the identity of the generative meristem. Plant J 5: 33-44 (1994).
2. Assaad FF, Tucker KL, Signer ER: Epignetic repeat-induced gene silencing (RIGS) in Arabidopsis. Plant Mol Biol 22: 1067-1085 (1993).
3. Barry C, Faugeron G, Rossignol J-L: Methylation induced premeiotically in Ascobulus: coextension with DNA repeat lengths and effect on transcript elongation. Proc Natl Acad Sci USA 90: 4557-4561 (1993).
4. Baulcombe DC: Replicase mediated resistance: a novel type of virus resistance in transgenic plants? Trends Microbiol 2: 60-63 (1994).
5. Baulcombe DC, English JJ: Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plants. Curr Opin Biotechnol 173-180 (1996).
6. Boerjan W, Bauw G, Van Montagu M, Inzé D: Distinct phenotypes generated by overexpression and supression of S-adenosyl-L-methionine synthetase reveal developmental patterns of gene silencing in tobacco. Plant Cell 6: 1401-1414 (1994).
7. Brandle JE, Mchugh SG, James L, Labbe H, Miki BL: Instability of transgene expression in-field grown tobacco carrying the csrl-l gene for sulfonylurea herbicide resistance. Bio/technology 13: 994-998 (1995).
8. Day AG, Bejarano ER, Buck KW, Burrell M, Lichtenstein CP: Expression of an antisense viral gene in transgenic tobacco confers resistance to the DNA virus tomato golden mosaic-virus. Proc Natl Acad Sci USA 88: 6721-6725 (1991).
9. de Borne FD, Vincentz M, Chupeau Y, Vaucheret H: Cosuppression of nitrate reductase host genes and transgenes in transgenic tobacco plants. Mol Gen Genet 243: 613-621 (1994).
10. de Carvalho Niebel F, Frendo P, Van Montagu M, Cornelissen M: Post-transcriptional cosuppression of β-glucanase genes does not affect accumulation of transgene nuclear mRNA. Plant Cell 7: 347-358 (1995).
11. de Carvalho F, Gheysen G, Kushnir S, Van Montagu M, Inzé D, Castresana C: Suppression of β-1, 3-glucanase transgene expression in homozygous plants. EMBO J 11: 2595-2602 (1992).
12. Dehio C, Schell J: Identification of plant genetic loci involved in posttranscriptional mechanism for meiotically reversible transgene silencing. Proc Natl Acad Sci USA 91: 5538-5542 (1994).
13. Elmayan T, Vaucheret H: Single copies of a 35S-driven transgene can undergo post-transcriptional silencing at each generation or can be transcriptionally inactivated in trans by a 35S silencer. Plant J 9: 787-797 (1996).
14. English JJ, Mueller E, Baulcombe DC: Suppression of virus accumulation in transgenic plants exhibiting silencing of nuclear genes. Plant Cell 8: 179-188 (1996).
15. Flavell RB, O'Dell M, Metzlaff M, Bonhomme S, and Cluster PD: Developmental regulation of co-suppression in Petunia hybrida. In: Meyer P (ed) Current Topics in Microbiology and Immunology Vol. 197: Gene Silencing in Higher Plants and Related Phenomena in Other Eukaryotes, Springer-Verlag, Berlin (1995).
16. Fray RG, Grierson D: Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequencing, complementation and co-suppression. Plant Mol Biol 22: 589-602 (1993).
17. Goodwin J, Chapman K, Parks TD, Wernsman EA, Dougherty WG: Genetic and biochemical dissection of transgenic RNA-mediated resistance. Plant Cell 8: 95-105 (1996).
18. Goring DR, Thomson L, Rothstein SJ: Transformation of a partial nopaline synthase gene in tobacco suppresses the expression of a resident wild-type gene. Proc Natl Acad Sci USA 88: 1770-1774 (1991).
19. Green PJ: Control of mRNA stability in higher plants. Plant Physiol 102: 1065-1070 (1993).
20. Grierson D, Fray RG, Hamilton AJ, Smith CJS, Watson CF: Does co-suppression of sense genes in transgenic plants involve antisense RNA? Trendo Biotechnol 9: 122-123 (1991).
21. Grierson D, Tucker GA, Keen J, Ray J, Bird CR, Schuch W: Sequencing and identification of a cDNA clone for tomato polygalacturonase. Nucl Acids Res 14: 8595-8603 (1986).
22. Hammond J, Kamo KK: Effective resistance to potyvirus infection conferred by expression of antisense RNA in transgenic plants. Mol Plant-Microbe Interact 8: 674-682 (1995).
23. Hart CM, Fischer B, Neuhaus JM, Meins F Jr: Regulated inactivation of homologous gene-expression in transgenic nicotiana-sylvestris plants containing a defense-related tobacco chitinase gene. Mol Gen Genet 235: 179-188 (1992).
24. Hobbs SLA, Kpodar P, DeLong CMO: The effect of T-DNA copy number, position and methylation on reporter gene expression in tobacco transformants. Plant Mol Biol 15: 851-864 (1990).
25. Hobbs SLA, Warkentin TD, DeLong CMO: Transgene copy number can be positively or negatively associated with transgene expression. Plant Mol Biol 21: 17-26 (1993).
26. Ingelbrecht I, Van Houdt H, Van Montagu M, Depicker A: Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation. Proc Natl Acad Sci USA 91: 10502-10506 (1994).
27. Jorgensen R, Que QD, English J, Cluster P, Napoli C: Sense-suppression of flower color genes as a sensitive reporter of epigenetic states of gene-expression in plant development. Plant Physiol 108: 14 (1995).
28. Jorgensen RA: Cosuppression, flower color patterns and metastable gene expression states. Science 268: 686-691 (1995).
29. Kawchuk LM, Martin RR, Mcpherson J: Sense and antisense RNA-mediated resistance to potato leafroll virus in Russet Burbank potato plants. Mol Plant-Microbe Interact 4: 247-253 (1991).
30. Kumagai MH, Donson J, Della-Cioppa G, Harvey D, Hanley K, Grill LK: Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA. Proc Natl Acad Sci USA 92: 1679-1683 (1995).
31. Lindbo JA, Dougherty WG: Pathogen-derived resistance to a potyvirus: immune and resistant phenotypes in transgenic tobacco expressing altered forms of a potyvirus coat protein nucleotide sequence. Mol Plant-Microbe Interact 5: 144-153 (1992).
32. Lindbo JA, Dougherty WG: Untranslatable transcripts of the tobacco etch virus coat protein gene sequence can interfere with tobacco etch virus replication in transgenic plants and protoplasts. Virology 189: 725-733 (1992).
33. Lindbo JA, Silva-Rosales L, Proebsting WM, Dougherty WG: Induction of a highly specific antiviral state in transgenic plants: implications for regulation of gene expression and virus resistance. Plant Cell 5: 1749-1759 (1993).
34. Longstaff M, Brigneti G, Boccard F, Chapman S, Baulcombe DC: Extreme resistance to potato virus X infection in plants expressing a modified component of the putative viral replicase. EMBOJ 12: 379-386 (1993).
35. Matzke MA, Matzke AJM: How and why do plants inactivate homologous (trans)genes? Plant Physiol 107: 6679-685 (1995).
36. Matzke, MA, Matzke, AJM, Sheid OM: Inactivation of repeated genes: DNA-DNA interaction? In: Paszkowski J (ed) Homologous Recombination and Gene Silencing in Plants. Kluwer Academic Publishers, Dordrecht (1995).
37. Matzke MA, Neuhuber F, Matzke AJM: A variety of epistatic interactions can occur between partially homologous transgene loci brought together by sexual crossing. Mol Gen Genet 236: 379-386 (1993).
38. Meyer P, Heidmann I: Epigenetic variants of a transgenic petunia line show hypermethylation in transgene DNA: an indication for specific recognition of foreign DNA in transgenic plants. Mol Gen Genet 243: 390-399 (1994).
39. Meyer P, Heidmann I, Niedenhof I: Differences in DNA-methylation are associated with a paramutation phenomenon in transgenic petunia. Plant J 4: 89-100 (1993).
40. Mueller E, Gilbert JE, Davenport G, Brigneti G, Baulcombe DC: Homology-dependent resistance: transgenic viras resistance in plants related to homology-dependent gene silencing. Plant J 7: 1001-1013 (1995).
41. Napoli C, Lemieux C, Jorgensen RA: Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2: 279-289 (1990).
42. Nellen W, Lichtenstein C: What makes an mRNA anti-senseitive? Trends Biochem Sci 18: 419-423 (1993).
43. Palmgren G, Mattson O, Okkels FT: Treatment of Agrobacterium or leaf disks with 5-azacytidine increases transgene expression in tobacco. Plant Mol Biol 21: 429-435 (1993).
44. Pang SZ, Slightom JL, Gonsalves D: Different mechanisms protect transgenic tobacco against tomato spotted wilt and impatiens necrotic spot tospoviruses. Bio/technology 11: 819-824 (1993).
45. Park Y-D, Papp I, Moscone EA, Iglesias VA, Vaucheret H, Matzke AJM, Matzke MA: Gene silencing mediated by promoter homology occurs at the level of transcription and results in meiotically heritable alterations in methylation and gene activity. Plant J 9: 183-194 (1996).
46. Phillips RL, Matzke MA, Oono K: Treasure your exceptions. Plant Cell 7: 1522-1527 (1995).
47. Seymour GB, Fray RG, Hill P, Tucker GA: Down-regulation of two non-homologous endogenous tomato genes with a single chimaeric sense gene construct. Plant Mol Biol 23: 1-9 (1993).
48. Smith CJS, Watson CF, Bird CR, Ray J, Schuch W, Grierson D: Expression of a truncated tomato polygalacturonase gene inhibits expression of the endogenous gene in transgenic plants. Mol Gen Genet 224: 447-481 (1990).
49. Smith HA, Powers H, Swaney S, Brown C, Dougherty WG: Transgenic potato virus Y resistance in potato: evidence for an RNA-mediated cellular response. Phytopathology 85: 864-870 (1995).
50. Smith HA, Swaney SL, Parks TD, Wernsman EA, Dougherty WG: Transgenic plant virus resistance mediated by untranslatable sense RNAs: expression, regulation, and fate of nonessential RNAs. Plant Cell 6: 1441-1453 (1994).
51. van Blokland R, van der Geest N, Mol JNM, Kooter JM: Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover. Plant J 6: 861-877 (1994).
52. van der Krol AR, Mur LA, Beld M, Mol JNM, Stuitje AR: Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell 2: 291-299 (1990).
53. N in tobacco plants transformed with the viral coat protein cistron. Plant Mol Biol 20: 631-639 (1992).
54. Vaucheret H, Palauqui JC, Elmayan T, Moffatt B: Molecular and genetic analysis of nitrite reductase co-suppression in transgenic tobacco plants. Mol Gen Genet 248: 311-317 (1995).
55. Wagner EGH, Simons RW: Antisense RNA control in bacteria, phage and plasmids. Annu Rev Microbiol (1994).
56. Wassenegger M, Heimes S, Riedel L, Sänger HL: Methylation of plant genome-integrated viroid cDNAs is induced upon replication of the corresponding viroid RNA: a novel mechanism of a RNA-directed sequence-specific de novo methylation of genes. Cell 76: 567-576 (1994).