Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: Evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucocorticoids

American Journal of Respiratory and Critical Care Medicine

Volumn 165, Issue 7, 2002, Pages 983-991

  Umberto Meduri, G ^a,b   Tolley, Elizabeth A ^a,b   Chrousos, George P ^a,b   Stentz, Frankie ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Acute respiratory distress syndrome; Glucocorticoid receptors; I B ; Methylprednisolone; Nuclear factor B

Indexed keywords

CORTICOTROPIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; METHYLPREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; INFLAMMATION; LEUKOCYTE; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEROID RELEASE;

EID: 0036528901     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.165.7.2106014     Document Type: Article

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