Duration of glucocorticoid treatment and outcome in sepsis: Is the right drug used the wrong way?

Chest

Volumn 114, Issue 2, 1998, Pages 355-360

  Meduri, G U ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; CYTOKINE; GLUCOCORTICOID; HYDROCORTISONE;

ARTERIAL PRESSURE; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; DRUG EFFECT; EDITORIAL; HOMEOSTASIS; HOST RESISTANCE; IMMUNE RESPONSE; PRIORITY JOURNAL; SEPSIS;

EID: 0031867469     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.114.2.355-a     Document Type: Editorial

References (52)

1. Bollaert PE Charpentier C Levy B Reversal of late septic shock with supraphysiological doses of hydrocortisone Crit Care Med 26 1998 645 650
2. Briegel J Haller M Forst H Effect of hydrocortisone on reversal of hyperdynamic septic shock: a randomized, double-blind, placebo-controlled, single-center study [abstract] Shock 7 1997 165
3. Meduri GU Headley AS Golden E Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress: a randomized controlled trial JAMA 279 1998 159 165
4. Bone RC Fisher CJ Jr. Clemmer TP Early methylprednisolone treatment for septic syndrome and the adult respiratory distress syndrome Chest 92 1987 1032 1036
5. Sprung CL Caralis PV Marcial EH The effects of high-dose corticosteroids in patients with septic shock N Engl J Med 311 1984 1137 1143
6. Bernard GR Luce JM Sprung CL High-dose corticosteroids in patients with the adult respiratory distress syndrome N Engl J Med 317 1987 1565 1570
7. Lefering R Neugebauer EAM Steroid controversy in sepsis and septic shock: a meta-analysis Crit Care Med 23 1995 1294 1303
8. Cronin L Cook DJ Carlet J Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature Crit Care Med 23 1995 1430 1439
9. Meduri GU The role of the host defense response in the progression and outcome of ARDS: pathophysiological correlations and response to glucocorticoid treatment Eur Respir J 9 1996 2650 2670
10. Chrousos GP The hypothalmic-pituitary-adrenal axis and immune-mediated inflammation N Engl J Med 332 1995 1351 1362
11. Elenkov I Papanicolaou D Wilder RL Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production Proc Assn Am Phys 108 1996 374 381
12. Bamberger CM Shulte HM Chrousos GP Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids Endocr Rev 17 1996 245 261
13. Scheinman RI Cogswell PC Lofquist AK Role of transcriptional activation of IκBa in mediation of immunosuppression by glucocorticoids Science 270 1995 283 290
14. Wissink S van Heerde EC van der Burg B A dual mechanism mediates repression of NF-κB activity by glucocorticoids Mol Endocrinol 12 1998 355 363
15. Barnes PJ Greening AP Crompton GK Glucocorticoid resistance in asthma Am J Respir Crit Care Med 152 1995 S125 S142
16. Pruzanski W Vadas P Phospholipase A2—a mediator between proximal and distal effectors of inflammation Immunol Today 12 1991 143 146
17. Albina JE Reichner JS Nitric oxide in inflammation and immunity New Horizons 3 1995 46 64
18. Meduri GU Belenchia JM Estes RJ Fibroproliferative phase of ARDS: clinical findings and effects of corticosteroids Chest 100 1991 943 952
19. Santos AA Scheltinga MR Lynch E Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia Arch Surg 128 1993 138 144
20. Hart PH Whitty GA Burgess DR Augmentation of glucocorticoid action on human monocytes by interleukin-4 Lymphokine Research 9 1990 147 153
21. Magiakou MA Mastorakos G Zachman K Chrousos GP Blood pressure in children and adolescents with Cushing syndrome before and after surgical cure J Clin Endocrinol Metab 82 1997 1734 1738
22. Headley AS Tolley E Meduri GU Infections and the inflammatory response in acute respiratory distress syndrome Chest 111 1997 1306 1321
23. Christou NV Host defense mechanisms of surgical patients: friend or foe? Arch Surg 131 1996 1136 1139
24. Guirao X Lowry SF Biologic control of injury and inflammation: much more than too little or too late World J Surg 20 1996 437 446
25. Schwartz MD Moore EE Moore FA Nuclear factor-κB is activated in alveolar macrophages from patients with acute respiratory distress syndrome Crit Care Med 24 1996 1285 1292
26. Maus U Pavlidis T Rosseau S Increased proinflammatory cytokine gene expression in alveolar macrophages is associated with changes in NF-κB DNA binding activity in septic ARDS [abstract] Am J Respir Crit Care Med 157 1998 A459
27. Bohrer H Qiu F Zimmermann T Role of NFκB in the mortality of sepsis J Clin Invest 100 1997 972 984
28. Papanicolaou D Wilder RL Manolagas SC The pathophysiologic roles of interleukin-6 in human disease Ann Intern Med 128 1998 127 137
29. Damas P Ledoux D Nys M Cytokine serum level during severe sepsis in human IL-6 as a marker of severity Ann Surg 215 1992 356 362
30. Calandra T Gerain J Heumann D High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines Am J Med 91 1991 23 29
31. Calandra T Baumgartner JD Grau GE Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-α, and interferon-γ in the serum of patients with septic shock J Infect Dis 161 1990 982 987
32. Pinski MR Vincent JL Deviere J Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality Chest 103 1993 565 575
33. Sullivan JS Kilpatrick L Costarino AT Jr Correlation of plasma cytokine elevations with mortality rate in children with sepsis J Pediatr 120 1992 510 515
34. Dofferhoff ASM de Jong HJ Bom VJJ Complement activation and the production of inflammatory mediators during the treatment of severe sepsis in humans Scand J Infect Dis 24 1992 197 204
35. Meduri GU Headley S Kohler G Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS: plasma IL-1β and IL-6 are consistent and efficient predictors of outcome over time Chest 107 1995 1062 1073
36. Almawi WY Lipman ML Stevens AC Abrogation of glucocorticosteroid-mediated inhibition of T cell proliferation by the synergistic action of IL-1, IL-6, and IFN-γ J Immunol 146 1991 3523 3527
37. Kam JC Szefler SJ Surs W Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids J Immunol 151 1993 3460 3466
38. Spahn JD Szefler SJ Surs W Induction of diminished monocyte glucocorticoid receptor-binding affinity J Immunol 157 1996 2654 2659
39. 2 in sheep with acute lung injury after high dose endotoxin infusion Am Rev Respir Dis 148 1993 878 881
40. Fan J Gong X Wu J Effect of glucocorticoid receptor (GR) blockade on endotoxemia in rats Circ Shock 42 1994 76 82
41. Molijn GJ Spek JJ van Uffelen JCJ Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock J Clin Endocrinol Metab 80 1995 1799 1803
42. Leung DYM Hamid Q Vottero A Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor β J Exp Med 186 1997 1567 1574
43. Chrousos GP Detera-Wadleigh SD Karl M Glucocorticoid resistant syndromes Ann Intern Med 119 1993 1113 1124
44. Meduri GU Headley S Tolley E Plasma and BAL cytokine response to corticosteroid rescue treatment in late ARDS Chest 108 1995 1315 1325
45. Briegel J Kellermann W Forst H Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome Clin Invest 72 1994 782 787
46. Meduri GU Headley EA Tolley A Plasma and BAL procollagen type I & III levels during ARDS and in response to prolonged methylprednisolone treatment [abstract] Am J Resp Crit Care Med 157 1998 A460
47. Hesterberg TW Last JA Ozone-induced acute pulmonary fibrosis in rats—prevention of increased rates of collagen synthesis by methylprednisolone Am Rev Respir Dis 123 1981 47 52
48. Hakkinen PJ Schmoyer RL Witschi HP Potentiation of butylated-hydroxytoluene-induced acute lung damage by oxygen: effects of prednisolone and indomethacin Am Rev Respir Dis 128 1983 648 651
49. Kehrer JP Klein-Szanto AJP Sorensen EMB Enhanced acute lung damage following corticosteroid treatment Am Rev Respir Dis 130 1984 256 261
50. Ashbaugh DG Maier RV Idiopathic pulmonary fibrosis in adult respiratory distress syndrome: diagnosis and treatment Arch Surg 120 1985 530 535
51. Hooper RG Kearl RA Established ARDS treated with a sustained course of adrenocortical steroids Chest 97 1990 138 143
52. Barber AE Coyle SM Marano MA Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man J Immunol 150 1993 1999 2006