Expression of p21(Cip1/Waf1/Sdi1) and p27(Kip1) cyclin-dependent kinase inhibitors during human hematopoiesis

Blood

Volumn 93, Issue 12, 1999, Pages 4167-4178

  Taniguchi, Toshiyasu ^a   Endo, Hisako ^a   Chikatsu, Norio ^a   Uchimaru, Kaoru ^a   Asano, Shigetaka ^a   Fujita, Toshiro ^a   Nakahata, Tatsutoshi ^a   Motokura, Toru ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P21; PROTEIN P27;

ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL SPECIFICITY; ERYTHROPOIESIS; GROWTH REGULATION; HUMAN; HUMAN CELL; MEGAKARYOPOIESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL CORD BLOOD;

EID: 0033564655     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.12.4167.412k05_4167_4178     Document Type: Article

References (63)

1. Morgan DO: Principles of CDK regulation. Nature 374:131, 1995
2. Sherr CJ, Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9:1149, 1995
3. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB: Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267:1018, 1995
4. Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ: p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267:1024, 1995
5. Zabludoff SD, Csete M, Wagner R, Yu X, Wold BJ: p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis. Cell Growth Differ 9:1, 1998
6. Durand B, Gao FB, Raff M: Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation. EMBO J 16:306, 1997
7. Fredersdorf S, Milne AW, Hall PA, Lu X: Characterization of a panel of novel anti-p21Waf1/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1/Cip1 expression in normal human tissues. Am J Pathol 148:825, 1996
8. el-Deiry WS, Tokino T, Waldman T, Oliner JD, Velculescu VE, Burrell M, Hill DE, Healy E, Rees JL, Hamilton SR, Kinzler KW, Vogelstein B: Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res 55:2910, 1995
9. Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, Massague J, Crabtree GR, Roberts JM: Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570, 1994
10. Solvason N, Wu WW, Kabra N, Wu X, Lees E, Howard MC: Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes. J Exp Med 184:407, 1996
11. Blanchard DA, Affredou MT, Vazquez A: Modulation of the p27kip1 cyclin-dependent kinase inhibitor expression during IL-4-mediated human B cell activation. J Immunol 158:3054, 1997
12. Sanchez-Beato M, Saez AI, Martinez-Montero JC, Sol Mateo M, Sanchez-Verde L, Villuendas R, Troncone G, Piris MA: Cyclin-dependent kinase inhibitor p27KIP1 in lymphoid tissue: p27KIP1 expression is inversely proportional to the proliferative index. Am J Pathol 151:151, 1997
13. Ciaparrone M, Yamamoto H, Yao Y, Sgambato A, Cattoretti G, Tomita N, Monden T, Rotterdam H, Weinstein IB: Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. Cancer Res 58:114, 1998
14. LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E: New functional activities for the p21 family of CDK inhibitors. Genes Dev 11:847, 1997
15. Zhang H, Hannon GJ, Beach D: p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8:1750, 1994
16. Thron CD: Bistable biochemical switching and the control of the events of the cell cycle. Oncogene 15:317, 1997
17. Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A: Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol 16:4673, 1996
18. Ogawa M: Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844, 1993
19. Jiang H, Lin J, Su ZZ, Collart FR, Huberman E, Fisher PB: Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene 9:3397, 1994
20. Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA, el-Houseini ME: Induction of p21 (WAF-1/CIP1) during differentiation. Oncogene 9:3389, 1994
21. Zhang W, Grasso L, McClain CD, Gambel AM, Cha Y, Travali S, Deisseroth AB, Mercer WE: p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 55:668, 1995
22. Schwaller J, Koeffler HP, Niklaus G, Loetscher P, Nagel S, Fey MF, Tobler A: Posttranscriptional stabilization underlies p53-independent induction of p21 WAF1/CIP1/SDI1 in differentiating human leukemic cells. J Clin Invest 95:973, 1995
23. Wang QM, Jones JB, Studzinski GP: Cyclin-dependent kinase inhibitor p27 as a mediator of the Gl-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells. Cancer Res 56:264, 1996
24. Zeng YX, el-Deiry WS: Regulation of p21WAF1/CIP1 expression by p53-independent pathways. Oncogene 12:1557, 1996
25. Asiedu C, Biggs J, Lilly M, Kraft AS: Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2. Cancer Res 55:3716, 1995
26. Matsumura I, Ishikawa J, Nakajima K, Oritani K, Tomiyama Y, Miyagawa J, Kato T, Miyazaki H, Matsuzawa Y, Kanakura Y: Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5. Mol Cell Biol 17:2933, 1997
27. Kikuchi J, Furukawa Y, Iwase S, Terui Y, Nakamura M, Kitagawa S, Kitagawa M, Komatsu N, Miura Y: Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: Involvement of cyclin-dependent kinase inhibitor p21 in polyploidization. Blood 89:3980, 1997
28. Uchimaru K, Taniguchi T, Yoshikawa M, Fujinuma H, Fujita T, Motokura T: Growth arrest associated with 12-o-tetradecanoylphorbol-13-acetate-induced hematopoietic differentiation with a defective retinoblastoma tumor suppressor-mediated pathway. Leuk Res 22:413, 1998
29. Asiedu C, Biggs J, Kraft AS: Complex regulation of CDK2 during phorbol ester-induced hematopoietic differentiation. Blood 90: 3430, 1997
30. Steinman RA, Huang J, Yaroslavskiy B, Goff JP, Ball ED, Nguyen A: Regulation of p21(WAF1) expression during normal myeloid differentiation. Blood 91:4531, 1998
31. Imai T, Koike K, Kubo T, Kikuchi T, Amano Y, Takagi M, Okumura N, Nakahata T: Interleukin-6 supports human megakaryocytic proliferation and differentiation in vitro. Blood 78:1969, 1991
32. Nakahata T, Ogawa M: Hemopoietic colony-forming cells in umbilical cord blood with extensive capability to generate mono-and multipotential hemopoietic progenitors. J Clin Invest 70:1324, 1982
33. Nakahata T, Spicer SS, Ogawa M: Clonal origin of human erythro-eosinophilic colonies in culture. Blood 59:857, 1982
34. Hurwitz R, Hozier J, LeBien T, Minowada J, Gajl-Peczalska K, Kubonishi I, Kersey J: Characterization of a leukemic cell line of the pre-B phenotype. Int J Cancer 23:174, 1979
35. Ogura M, Morishima Y, Okumura M, HottaT, Takamoto S, Ohno R, Hirabayashi N, Nagura H, Saito H: Functional and morphological differentiation induction of a human megakaryoblastic leukemia cell line (MEG-01s) by phorbol diesters. Blood 72:49, 1988
36. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
37. Uchimaru K, Taniguchi T, Yoshikawa M, Asano S, Arnold A, Fujita T, Motokura T: Detection of cyclin D1 (bcl-1, PRAD1) overexpression by a simple competitive reverse transcription-polymerase chain reaction assay in t(11;14)(q13;q32)-bearing B-cell malignancies and/or mantle cell lymphoma. Blood 89:965, 1997
38. Hill HD, Straka JG: Protein determination using bicinchoninic acid in the presence of sulfhydryl reagents. Anal Biochem 170:203, 1988
39. Vrhovac R, Delmer A, Tang RP, Marie JP, Zittoun R, Ajchenbaum-Cymbalista F: Prognostic significance of the cell cycle inhibitor p27Kip1 in chronic B-cell lymphocytic leukemia. Blood 91:4694, 1998
40. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T: p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 9:935, 1995
41. Reynisdottir I, Massague J: The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev 11:492, 1997
42. Pellegrini W, Facchetti F, Marocolo D, Salvi L, Capucci A, Tironi A, Rossi G: Assessment of cell proliferation in normal and pathological bone marrow biopsies: A study using double sequential immunophenotyping on paraffin sections. Histopathology 27:397, 1995
43. Wagner EF, Hieb M, Hanna N, Sharma S: A pivotal role of cyclin D3 and cyclin-dependent kinase inhibitor p27 in the regulation of IL-2-, IL-4-, or IL-10-mediated human B cell proliferation. J Immunol 161:1123, 1998
44. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133: 1710, 1984
45. Brown DC, Gatter KC: Monoclonal antibody Ki-67: Its use in histopathology. Histopathology 17:489, 1990
46. Budke H, Orazi A, Neiman RS, Cattoretti G, John K, Barberis M: Assessment of cell proliferation in paraffin sections of normal bone marrow by the monoclonal antibodies Ki-67 and PCNA. Mod Pathol 7:860, 1994
47. Chin YE, Kitagawa M, Su WC, You ZH, Iwamoto Y, Fu XY: Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 272:719, 1996
48. Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth PK, Dotto GP: Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 280: 1069, 1998
49. Ponten F, Berne B, Ren ZP, Nister M, Ponten J: Ultraviolet light induces expression of p53 and p21 in human skin: Effect of sunscreen and constitutive p21 expression in skin appendages. J Invest Dermatol 105:402, 1995
50. Nagata Y, Muro Y, Todokoro K: Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis. J Cell Biol 139:449, 1997
51. Vitrat N, Cohen-Solal K, Pique C, Le Couedic JP, Norol F, Larsen AK, Katz A, Vainchenker W, Debili N: Endomitosis of human megakaryocytes are due to abortive mitosis. Blood 91:3711, 1998
52. Deng C, Zhang P, Harper JW, Elledge SJ, Leder P: Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675, 1995
53. Mantel C, Luo Z, Canfield J, Braun S, Deng C, Broxmeyer HE: Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo. Blood 88:3710, 1996
54. Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM: A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 85:733, 1996
55. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M: Role of the ubiquitin-proteasome pathway in regulating abundance of the cydin-dependent kinase inhibitor p27. Science 269:682, 1995
56. Hengst L, Reed SI: Translational control of p27Kip1 accumulation during the cell cycle. Science 271:1861, 1996
57. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M: Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas, Nat Med 3:231, 1997
58. Kawamata S, Sakaida H, Hori T, Maeda M, Uchiyama T: The upregulation of p27Kip1 by Rapamycin results in G1 arrest in exponentially growing T-cell lines. Blood 91:561, 1998
59. Lalli E, Sassone-Corsi P, Ceredig R: Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway. EMBO J 15:528, 1996
60. Kamesaki H, Nishizawa K, Michaud GY, Cossman J, Kiyono T: TGF-betal induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells. J Immunol 160:770, 1998
61. Dao MA, Taylor N, Nolta JA: Reduction in levels of the cyclin-dependent kinase inhibitor p27kip-1 coupled with transforming growth factor β neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells. Proc Natl Acad Sci USA 95:13006, 1998
62. Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP: Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 10:142, 1996
63. Kuwano K, Kunitake R, Kawasaki M, Nomoto Y, Hagimoto N, Nakanishi Y, Hara N: P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 154:477, 1996