Consistent amounts of acute leukemia-associated P190BCR/ABL transcripts are expressed by chronic myelogenous leukemia patients at diagnosis

Blood

Volumn 87, Issue 3, 1996, Pages 1075-1080

  Saglio, Giuseppe ^a   Pane, Fabrizio ^b   Gottardi, Enrico ^b   Frigeri, Ferdinando ^b   Buonaiuto, Maria Rosaria ^b   Guerrasio, Angelo ^b   De Micheli, Daniela ^b   Parziale, Adele ^b   Fornaci, Maria Nella ^b   Martinelli, Giovanni ^b   Salvatore, Francesco ^b  

^a SAN LUIGI GONZAGA HOSPITAL   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; MESSENGER RNA; PROTEIN P190; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LEUKOCYTE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 13344295068     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.3.1075.bloodjournal8731075     Document Type: Article

References (19)

1. Kurzrock R, Gutterman JU, Talpaz M. The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 319:990, 1988
2. Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G: Philadelphia chromosome breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 36:93, 1984
3. Shtivelman E, Lifshitz B, Gale RP, Canaani E: Fused transcript of abl and bcr genes in chronic myelogenous leukemia. Nature 315:550, 1985
4. Hermans A, Heisterkamp N, von Linderen M, van Baal S, Meijer D, van der Plas D, Wiedemann LM, Groffen J, Bootsma D, Grosveld G: Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia. Cell 51:33, 1987
5. Clark S, McLaughlin J, Crist WM, Champlin R, Witte ON: Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL. Science 235:85, 1987
6. Sokal JE, Baccarani M, Russo D, Tura S: Staging and prognosis in chronic myelogenous leukemia. Semin Hematol 25:49, 1988
7. Guerrasio A, Martinelli G, Saglio G, Rosso C, Zaccaria A, Rosti G, Testoni N, Ambrosetti A, Izzi T, Sessarego M, Frassoni F, Gasparini P, Chiamenti A, Di Bartolomeo P, Pignatti PF: Minimal residual disease status in transplanted CML patients: Low incidence of PCR positive cases among 48 long disease-free patients who received unmanipolated allogeneic bone marrow transplantation. Leukemia 6:507, 1992
8. Zaccaria A, Tassinari A, Angeri R, Guerrasio A, Rosso C, Saglio G: Alternative types of bcr/abl transcripts in CML. Blood 76:1663, 1990
9. Pane F, Salera A, Mostarda I, Salvatore F, Sacchetti L: Estimation of extremely low amounts of single mRNAs by quantitative non competitive RT-PCR assay in biological specimen from normal and neoplastic cells. Anal Biochem 225:362, 1995
10. bcr-abl in mature granulocytes from Ph1-positive chronic myelogenous leukemia patients by an immunoblotting method. Leukemia. 7:1168, 1993
11. Selleri L, von Linderen M, Hermans A, Meijer D, Torelli G, Grosveld G: Chronic myeloid leukemia may be associated with several bcr/abl transcripts including the acute lymphoid leukemia-type 7 kb transcript. Blood 75:1146, 1990
12. Saglio G, Guerrasio A, Rosso C, Zaccaria A, Tassinari A, Serra A, Rege-Cambrin G, Mazza U, Gavosto F: New type of BCR/ ABL junction in Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 76:1819, 1990
13. Lugo TG, Pandergast AM, Muller AJ, Witte OW: Tyrosine kinase activity and transformation potency of bcr/abl oncogene product. Science 24:1079, 1990
14. Kelliher M, Knott A, McLaughkin J, Witte ON, Rosemberg N: Differences in oncogenic potency but not target cell specificty distinguish the two forms of the BCR/ABL oncogene. Mol Cell Biol 11:4710, 1991
15. Kantarjan HM, Talpaz M, Dhingra K, Estey E, Keating MJ, Ku S, Trujillo J, Huh Y, Stass S, Kurzrock R: Significance of the P210 versus P190 molecular abnormalities in adults with Philadelphia chromosome positive acute leukemia. Blood 78:2411, 1991
16. Maurer J, Jassen WGJ, Thiel E, van Denderen J, Ludwig WD, Aydemir U, Heinze B, Fonatsch C, Harbott J, Reiter A, Riehm H, Hoelzer D, Bartram CR: Detection of chimeric BCR/ABL genes in acute lymphoblastic leukemia by the polymerase chain reaction. Lancet 337:1055, 1991
17. BCR/ABL in chronic myelogenous leukemia may correlate with disease progression. Leukemia 5:191, 1991
18. Cross NCP, Feng L, Chase A, Bungley J, Hughes T, Goldman JM: Competitive polymerase chain reaction to estimate the number of BCR/ABL transcripts in chronic myelogenous leukemia patients after bone marrow transplantation. Blood 82:1929, 1993
19. Shibata K, Nishimura J, Takira H, Nawata H: Phosphotyrosine phosphatase activity prevents the detection of P210 protein in mature cells in chronic myelogenous leukemia even by an immunoblotting technique. Leukemia 3:615, 1989