A nitroimidazole derivative, PR-350, enhances the killing of pancreatic cancer cells exposed to high-dose irradiation under hypoxia

Journal of Radiation Research

Volumn 43, Issue 1, 2002, Pages 43-51

  Mizumoto, Kazuhiro ^a   Qian, Li Wu ^a   Zhang, Li ^a   Nagai, Eishi ^a   Kura, Shinobu ^a   Tanaka, Masao ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Cell death; High dose irradiation; Hypoxia; Pancreatic cancer; Radio sensitizer

Indexed keywords

CELL CULTURE; DISEASES; GAMMA RAYS; IRRADIATION;

CELL-BE; CELL/B.E; CELL/BE; DOSE IRRADIATION; HIGH DOSE; HIGH DOSE IRRADIATION; HYPOXIA; PANCREATIC CANCERS; RADIO-SENSITIZER; SENSITISER;

CELL DEATH;

DNA; DORANIDAZOLE; IMIDAZOLE DERIVATIVE; RADIOSENSITIZING AGENT;

ARTICLE; CELL CULTURE; CELL DEATH; CELL HYPOXIA; DRUG EFFECT; HUMAN; PANCREAS TUMOR; RADIATION DOSE; RADIATION EXPOSURE;

CELL DEATH; CELL HYPOXIA; DNA, NEOPLASM; HUMANS; IMIDAZOLES; PANCREATIC NEOPLASMS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 0036515645     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.43.43     Document Type: Article

References (27)

1. Warshaw, A. L. and Fernandez-del Castillo C. (1992) Pancreatic carcinoma. N. Engl. J. Med. 326: 455-465.
2. Tepper, J., Nardi G. and Sutt H. (1976) Carcinoma of the pancreas: review of MGH experience from 1963 to 1973. Analysis of surgical failure and implications for radiation therapy. Cancer 37: 1519-1524.
3. Griffin, J. F., Smalley S. R., Jewell W., Paradelo J. C., Reymond R. D., Hassanein R. E. and Evans R. G. (1990) Patterns of failure after curative resection of pancreatic carcinoma. Cancer 66: 56-61.
4. Johnstone, P.A. and Sindelar W.F. (1993) Patterns of disease recurrence following definitive therapy of adenocarcinoma of the pancreas using surgery and adjuvant radiotherapy:correlations of a clinical trial. Int. J. Radiat. Oncol. Biol. Phys. 27: 831-834.
5. Gastrointestinal Tumor Study Group. (1988) Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J. Natl. Cancer Inst. 80: 751-755.
6. Staley, C. A., Lee J. E., Cleary K. R., Abbruzzese J. L., Fenoglio C. J., Rich T. A. and Evans D. B. (1996) Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head. Am. J. Surg. 171: 118-124.
7. Shibamoto, Y., Manabe T., Baba N., Sasai K., Takahashi M., Tobe T. and Abe M. (1990) High dose, external beam and intraoperative radiotherapy in the treatment of resectable and unresectable pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 19: 605-611.
8. Coleman, C. N. (1996) Conference summary: the ninth international conference on the Chemical Modifiers of Cancer Treatment. Br. J. Cancer - Supplement 27: S297-304.
9. Rauth, A. M., Melo T. and Misra V. (1998) Bioreductive therapies: an overview of drugs and their mechanisms of action. Int. J. Radiat. Oncol. Biol. Phys. 42: 755-762.
10. Denny, W. A., Wilson W. R. and Hay M. P. (1996) Recent developments in the design of bioreductive drugs. Br. J. Cancer - Supplement 27: S32-38.
11. Dische, S. (1989) Keynote address: hypoxic cell sensitizers: clinical developments. Int. J. Radiat. Oncol. Biol. Phys. 16: 1057-1060.
12. Lee, D.J., Cosmatos D., Marcial V.A., Fu K.K., Rotman M., Cooper J.S., Ortiz H.G., Beitler J.J., Abrams R.A., Curran W.J. and et al. (1995) Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 32: 567-576.
13. Murayama, C., Suzuki A., Sato C., Tanabe Y., Shoji T., Miyata Y., Nishio A., Suzuki T., Sakaguchi M. and Mori T. (1993) Radiosensitization by a new potent nucleoside analog: 1 -(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole(RP-343). Int. J. Radiat. Oncol. Biol. Phys. 26: 433-443.
14. Oya, N., Shihamoto Y., Sasai K., Shibata T., Murata R., Takagi T., Iwai H., Suzuki T. and Abe M. (1995) Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): radiosensitization efficiency and toxicity. Int. J. Radiat. Oncol. Biol. Phys. 33: 119-127.
15. Courtenay, V. D., Smith I. E. and Steel G. G. (1978) The effect of misonidazole on the radiation response of clonogenic human pancreatic carcinoma cells. Br. J. Cancer - Supplement 37: 225-227.
16. Lawrence, T. S., Chang E. Y., Hahn T. M., Hertel L. W. and Shewach D. S. (1996) Radiosensitization of pancreatic cancer cells by 2',2'-difluoro-2'-deoxycytidine. Int. J. Radiat. Oncol. Biol. Phys. 34: 867-872.
17. Verovski, V. N., Van den Berge D. L., Soete G. A., Bols B. L. and Storme G.A. (1996) Intrinsic radiosensitivity of human pancreatic tumour cells and the radiosensitising potency of the nitric oxide donor sodium nitroprusside. Br. J. Cancer 74: 1734-1742.
18. Coucke, P. A., Decosterd L. A., Li Y. X., Cottin E., Chen X., Sun L. Q., Stern S., Paschoud N. and Denekamp J. (1999) The ribonucleoside diphosphate reductase inhibitor (E)-2'-deoxy-(fluoromethylene) cytidine as a cytotoxic radiosensitizer in vitro. Cancer Res. 59: 5219-5226.
19. Chmura, S. J., Mauceri H. J., Advani S., Heimann R., Beckett M. A., Nodzenski E., Quintans J., Kufe D. W. and Weichselbaum R. R. (1997) Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res 57: 4340-4347.
20. Zhang, L., Mizumoto K., Sato N., Ogawa T., Kusumoto M., Niiyama H. and Tanaka M. (1999) Quantitative determination of apoptotic death in cultured human pancreatic cancer cells by propidium iodide and digitonin. Cancer Lett. 142: 129-137.
21. Bernhard, E. J., McKenna W. G., Hamilton A. D., Sebti S. M., Qian Y., Wu J. M. and Muschel R. J. (1998) Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes. Cancer Res. 58: 1754-1761.
22. Robertson, J. M., Shewach D. S. and Lawrence T. S. (1996) Preclinical studies of chemotherapy and radiation therapy for pancreatic carcinoma. Cancer 78: 674-679.
23. Samejima, K., Tone S., Kottke T. J., Enari M., Sakahira H., Cooke C. A., Durrieu F., Martins L. M., Nagata S., Kaufmann S. H. and Earnshaw W.C. (1998) Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution. J. Cell. Biol. 143: 225-239.
24. Kagawa, S., Fujiwara T., Hizuta A., Yasuda T., Zhang W.W., Roth J.A. and Tanaka N. (1997) p53 expression overcomes p2 IWAF1/CIP1 mediated G1 arrest and induces apoptosis in human cancer cells. Oncogene 15: 1903-1909.
25. Waldman, T., Zhang Y., Dillehay L., Yu J., Kinzler K., Vogelstein B. and Williams J. (1997) Cell-cycle arrest versus cell death in cancer therapy . Nature Med. 3: 1034-1036.
26. Kurdoglu, B., Cheong N., Guan J., Corn B. W., Curran W. J., Jr. and Iliakis G. (1999) Apoptosis as a predictor of paclitaxel-induced radiosensitization in human tumor cell lines. Clin. Cancer Res. 5: 2580-2587.
27. Coco Martin, J. M., Balkenende A., Verschoor T., Lallemand F. and Michalides R. (1999) Cyclin D1 overexpression enhances radiation-induced apoptosis and radiosensitivity in a breast tumor cell line. Cancer Res. 59: 1134-1140.