-
1
-
-
0026593802
-
Decrease in TTP mediated by 5′-bromo-2′-deoxyuridine exposure in a human glioblastoma cell line
-
Shewach, D. S., Ellero, J., Mancini, W. R., and Ensminger, W. D. Decrease in TTP mediated by 5′-bromo-2′-deoxyuridine exposure in a human glioblastoma cell line. Biochem. Pharmacol., 43: 1579-1585, 1992.
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 1579-1585
-
-
Shewach, D.S.1
Ellero, J.2
Mancini, W.R.3
Ensminger, W.D.4
-
2
-
-
0025737572
-
2′Deoxy-2′methylencytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphate: Potent mechanism-based inhibitors of ribonucleotide reductase
-
Baker, C. H., Banzon, J., Bollinger, J. M., and Stubbe, J. 2′Deoxy-2′methylencytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphate: potent mechanism-based inhibitors of ribonucleotide reductase. J. Med. Chem., 34: 1879-1885, 1991.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1879-1885
-
-
Baker, C.H.1
Banzon, J.2
Bollinger, J.M.3
Stubbe, J.4
-
3
-
-
0025028093
-
Cytotoxicity and antitumor activity of 2′,2′-difluorodeoxycytidine (gemcitabine)
-
Grindey, G. B., Hertel, L. W., and Plunkett, W. Cytotoxicity and antitumor activity of 2′,2′-difluorodeoxycytidine (gemcitabine). Cancer Investig., 8: 313, 1990.
-
(1990)
Cancer Investig.
, vol.8
, pp. 313
-
-
Grindey, G.B.1
Hertel, L.W.2
Plunkett, W.3
-
4
-
-
0025325071
-
Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine)
-
Hertel, L. W., Boder, G., Kroin, J. S., Rinzel, S. M., Poore, G. A., Todd, G. C., and Grindey, G. B. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine). Cancer Res., 50: 4417-4422, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 4417-4422
-
-
Hertel, L.W.1
Boder, G.2
Kroin, J.S.3
Rinzel, S.M.4
Poore, G.A.5
Todd, G.C.6
Grindey, G.B.7
-
5
-
-
0026324313
-
Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
-
Huang, P., Chubb, S., Hertel, L. W., Grindey, G. B., and Plunkett, W. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res., 51: 6110-6117, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 6110-6117
-
-
Huang, P.1
Chubb, S.2
Hertel, L.W.3
Grindey, G.B.4
Plunkett, W.5
-
6
-
-
0344329781
-
Hydroxyurea-mediated radiosensitization: An in vitro study in a human squamous cell cancer cell line (KB)
-
Oxford, United Kingdom: Christ Church
-
Kinsella, T. J., Kunugi, K. A., and Yen, Y. Hydroxyurea-mediated radiosensitization: an in vitro study in a human squamous cell cancer cell line (KB). In: Abstract II-49 Ninth International Conference on Chemical Modifiers of Cancer Treatment, pp. 181-182. Oxford, United Kingdom: Christ Church, 1995.
-
(1995)
Abstract II-49 Ninth International Conference on Chemical Modifiers of Cancer Treatment
, pp. 181-182
-
-
Kinsella, T.J.1
Kunugi, K.A.2
Yen, Y.3
-
7
-
-
0344761832
-
Radiosensitization by hydroxyurea in a cervical carcinoma cell line, Caski
-
Oxford, United Kingdom: Christ Church
-
Kuo, M. L., and Kinsella, T. J. Radiosensitization by hydroxyurea in a cervical carcinoma cell line, Caski. In: Abstract 11-50 Ninth International Conference on Chemical Modifiers of Cancer Treatment, pp. 183-184 Oxford, United Kingdom: Christ Church, 1995.
-
(1995)
Abstract 11-50 Ninth International Conference on Chemical Modifiers of Cancer Treatment
, pp. 183-184
-
-
Kuo, M.L.1
Kinsella, T.J.2
-
8
-
-
0030005273
-
Radiosensitization of pancreatic cells by 2′,2′-difluoro-2′-deoxycytidine
-
Lawrence, T. S., Chang, E., Y., Hahn, T. M., Hertel, L. W., and Shewach, D. S. Radiosensitization of pancreatic cells by 2′,2′-difluoro-2′-deoxycytidine. Int. J. Radiat. Oncol. Biol. Phys., 34: 867-872, 1996.
-
(1996)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.34
, pp. 867-872
-
-
Lawrence, T.S.1
Chang, E.Y.2
Hahn, T.M.3
Hertel, L.W.4
Shewach, D.S.5
-
9
-
-
0026984625
-
Effect of 2′,2-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro
-
Rockwell, S., and Grindey, G. B. Effect of 2′,2-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro. Oncol. Res., 4: 5151-5155, 1992.
-
(1992)
Oncol. Res.
, vol.4
, pp. 5151-5155
-
-
Rockwell, S.1
Grindey, G.B.2
-
10
-
-
0028240063
-
Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells
-
Shewach, D. S., Hahn, T. M., Chang, E., Hertel, L. W., and Lawrence, T. S. Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res., 54: 3218-3223, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 3218-3223
-
-
Shewach, D.S.1
Hahn, T.M.2
Chang, E.3
Hertel, L.W.4
Lawrence, T.S.5
-
11
-
-
0027959222
-
Effect of 2′-deoxy-2′(fluoromethylene) cytidine on the ultraviolet and x-ray sensitivity of HeLa cells
-
Snyder, R. D. Effect of 2′-deoxy-2′(fluoromethylene) cytidine on the ultraviolet and x-ray sensitivity of HeLa cells. Oncol. Res., 6: 177-182, 1994.
-
(1994)
Oncol. Res.
, vol.6
, pp. 177-182
-
-
Snyder, R.D.1
-
12
-
-
0027165660
-
Hydroxyurea versus misonidazole with radiation in cervical carcinoma: Long-term follow-up of a Gynecologic Oncology Group Trial
-
Stehman, F. B., Bundy, B. N., Thomas, G., Keys, H. M., Fowler, W. C., Mortel, R., and Creasman, W. T. Hydroxyurea versus misonidazole with radiation in cervical carcinoma: long-term follow-up of a Gynecologic Oncology Group Trial. J. Clin. Oncol., 11: 1523-1528, 1993.
-
(1993)
J. Clin. Oncol.
, vol.11
, pp. 1523-1528
-
-
Stehman, F.B.1
Bundy, B.N.2
Thomas, G.3
Keys, H.M.4
Fowler, W.C.5
Mortel, R.6
Creasman, W.T.7
-
13
-
-
0030868521
-
Antitumor and radiosensitizing effects of (E)-2′-deoxy-2′(fluoromethylene)cytidine, a novel inhibitor of ribonucleoside diphosphate reductase on human colon carcinoma xenografts in nude mice
-
Sun, L-Q., Li, Y-X., Guillou, L., Mirimanoff, R-O., and Coucke, P. A. Antitumor and radiosensitizing effects of (E)-2′-deoxy-2′(fluoromethylene)cytidine, a novel inhibitor of ribonucleoside diphosphate reductase on human colon carcinoma xenografts in nude mice. Cancer Res., 57: 4023-4028, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 4023-4028
-
-
Sun, L.-Q.1
Li, Y.-X.2
Guillou, L.3
Mirimanoff, R.-O.4
Coucke, P.A.5
-
14
-
-
0032403127
-
(E)-2′-Deoxy-2′(fluoromethylene)cytidine potentiates radioresponse of two human solid tumor xenografts
-
Sun, L-Q., Li, Y-X., Guillou, L., and Coucke, P. A. (E)-2′-Deoxy-2′(fluoromethylene)cytidine potentiates radioresponse of two human solid tumor xenografts. Cancer Res., 58: 5411-5417, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 5411-5417
-
-
Sun, L.-Q.1
Li, Y.-X.2
Guillou, L.3
Coucke, P.A.4
-
15
-
-
0029039072
-
Hydroxyurea with continuous infusion paclitaxel, 5-fluorouracil, and concomitant radiotherapy for poor-prognosis head and neck cancers
-
Vokes, E. E., Stupp, R., Haraf, D. J., Moran, W., Malone, D., Wenig, B., Sweeney, P., and Weichselbaum, R. R. Hydroxyurea with continuous infusion paclitaxel, 5-fluorouracil, and concomitant radiotherapy for poor-prognosis head and neck cancers. Semin. Oncol., 22 (Suppl. 6): 47-52, 1995.
-
(1995)
Semin. Oncol.
, vol.22
, Issue.6 SUPPL.
, pp. 47-52
-
-
Vokes, E.E.1
Stupp, R.2
Haraf, D.J.3
Moran, W.4
Malone, D.5
Wenig, B.6
Sweeney, P.7
Weichselbaum, R.R.8
-
16
-
-
0028794108
-
An ion-pairing high-performance liquid chromatography method for the direct simultaneous determination of nucleotides, desoxynucleotides, nicotinic coenzymes, oxypurines, nucleosides and bases in perchloric acid cell extracts
-
Di Pierro, D., Tavazzi, B., Perno, C. F., Bartolini, E., Calio, R., Giardina, B., and Lazzarino, G. An ion-pairing high-performance liquid chromatography method for the direct simultaneous determination of nucleotides, desoxynucleotides, nicotinic coenzymes, oxypurines, nucleosides and bases in perchloric acid cell extracts. Anal. Biochem., 231: 407-412, 1995.
-
(1995)
Anal. Biochem.
, vol.231
, pp. 407-412
-
-
Di Pierro, D.1
Tavazzi, B.2
Perno, C.F.3
Bartolini, E.4
Calio, R.5
Giardina, B.6
Lazzarino, G.7
-
17
-
-
0025049372
-
Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine
-
Heinemann, V., Xu, Y-Z., Chubb, S., Sen, A., Hertel, L. W., Grindey, G. B., and Plunkett, W. Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine. Mol. Pharmacol., 38: 567-572, 1990.
-
(1990)
Mol. Pharmacol.
, vol.38
, pp. 567-572
-
-
Heinemann, V.1
Xu, Y.-Z.2
Chubb, S.3
Sen, A.4
Hertel, L.W.5
Grindey, G.B.6
Plunkett, W.7
-
18
-
-
0027530045
-
Improved synthesis of (E)-2′-deoxy-2′-(fluoromethylene)cytidine - A potent inhibitor of ribonucleotide diphosphate reductase
-
Matthews, D. P., Persichetti, R. A., Sabol, J. S., Stewart, K. T., and McCarthy, J. R. Improved synthesis of (E)-2′-deoxy-2′-(fluoromethylene)cytidine - a potent inhibitor of ribonucleotide diphosphate reductase. Nucleosides Nucleotides, 12: 115-123, 1993.
-
(1993)
Nucleosides Nucleotides
, vol.12
, pp. 115-123
-
-
Matthews, D.P.1
Persichetti, R.A.2
Sabol, J.S.3
Stewart, K.T.4
McCarthy, J.R.5
-
19
-
-
0026059272
-
Stereospecific method to e and Z terminal fluoro olefins and application to the synthesis of 2′-deoxy-2′-fluoromethylene nucleosides as potential inhibitors of ribonucleoside diphosphate reductase
-
McCarthy, J. R, Matthews, D. P., Stemerick, D. M., Huber, E. W., Bey, P., Lippert, B. J., Snyder, R. D., and Sunkara, P. S. Stereospecific method to E and Z terminal fluoro olefins and application to the synthesis of 2′-deoxy-2′-fluoromethylene nucleosides as potential inhibitors of ribonucleoside diphosphate reductase. J. Am. Chem. Soc., 113: 7439-7440, 1991.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 7439-7440
-
-
McCarthy, J.R.1
Matthews, D.P.2
Stemerick, D.M.3
Huber, E.W.4
Bey, P.5
Lippert, B.J.6
Snyder, R.D.7
Sunkara, P.S.8
-
20
-
-
0028210794
-
Regression of human breast tumor xenografts in response to (E)-2′-deoxy-2′-(fluoromethylene)cytidine, an inhibitor of ribonucleotide diphosphate reductase
-
Bitonti, A. I., Dumont, J. A., Bush, T. L., Cashman, E. A., Cross-Doersen, D. E., Wright, P. S., Matthews, D. P., McCarthy, J. R., and Kaplan, D. A. Regression of human breast tumor xenografts in response to (E)-2′-deoxy-2′-(fluoromethylene)cytidine, an inhibitor of ribonucleotide diphosphate reductase. Cancer Res., 54: 1485-1490, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 1485-1490
-
-
Bitonti, A.I.1
Dumont, J.A.2
Bush, T.L.3
Cashman, E.A.4
Cross-Doersen, D.E.5
Wright, P.S.6
Matthews, D.P.7
McCarthy, J.R.8
Kaplan, D.A.9
-
21
-
-
0029166218
-
Response of human colon and prostate tumor xenografts to (E)-2′-deoxy-2′-(fluoromethylene)cytidine, an inhibitor of ribonucleotide reductase
-
Bitonti, A. J., Bush, T. L, Lewis, M. T., and Sunkara, P. S. Response of human colon and prostate tumor xenografts to (E)-2′-deoxy-2′-(fluoromethylene)cytidine, an inhibitor of ribonucleotide reductase. Anticancer Res., 15: 1179-1182, 1995.
-
(1995)
Anticancer Res.
, vol.15
, pp. 1179-1182
-
-
Bitonti, A.J.1
Bush, T.L.2
Lewis, M.T.3
Sunkara, P.S.4
-
22
-
-
0030029803
-
In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101.731, a novel ribonucleotide diphosphate reductase inhibitor
-
Piepmeyer, J., Rabidou, N., Schold, C., Bitonti, A. J., Prakash, N. J., and Bush, T. L. In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101.731, a novel ribonucleotide diphosphate reductase inhibitor. Cancer Res., 56: 539-361, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 539-1361
-
-
Piepmeyer, J.1
Rabidou, N.2
Schold, C.3
Bitonti, A.J.4
Prakash, N.J.5
Bush, T.L.6
-
23
-
-
0031985511
-
3 cells
-
3 cells. Cancer Chemother. Pharmacol., 41: 268-274, 1998.
-
(1998)
Cancer Chemother. Pharmacol.
, vol.41
, pp. 268-274
-
-
Takahashi, T.1
Nakashima, A.2
Kanazawa, J.3
Yamaguchi, K.4
Akinaga, S.5
Tamaoki, T.6
Okabe, M.7
-
24
-
-
0033562812
-
Simultaneous determination of deoxyribonucleosides in the presence of ribonucleoside triphosphates in human carcinoma cells by high performance liquid chromatography
-
Decosterd, L. A., Cottin, E., Chen, X., Lejeune, F., Mirimanoff, R. O., Biollaz, J., and Coucke, P. A. Simultaneous determination of deoxyribonucleosides in the presence of ribonucleoside triphosphates in human carcinoma cells by high performance liquid chromatography. Anal. Biochem., 270: 59-68, 1999.
-
(1999)
Anal. Biochem.
, vol.270
, pp. 59-68
-
-
Decosterd, L.A.1
Cottin, E.2
Chen, X.3
Lejeune, F.4
Mirimanoff, R.O.5
Biollaz, J.6
Coucke, P.A.7
-
25
-
-
0028783440
-
Induction of apoptosis by gemcitabine
-
Huang, P., and Plunkett, W. Induction of apoptosis by gemcitabine. Semin. Oncol., 22: 19-25, 1995.
-
(1995)
Semin. Oncol.
, vol.22
, pp. 19-25
-
-
Huang, P.1
Plunkett, W.2
-
26
-
-
0028181452
-
Radiation response of mouse lymphoid and myeloid cell lines: Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double strand breakage
-
Radford, I. R., and Murphy, T. K. Radiation response of mouse lymphoid and myeloid cell lines: different signals can lead to apoptosis and may influence sensitivity to killing by DNA double strand breakage. Int. J. Radiat. Biol., 65: 229-239, 1994.
-
(1994)
Int. J. Radiat. Biol.
, vol.65
, pp. 229-239
-
-
Radford, I.R.1
Murphy, T.K.2
|