Substrate proteolysis is inhibited by dominant-negative Nedd4 and Rsp5 mutants harboring alterations in WW domain 1

Journal of Cell Science

Volumn 115, Issue 5, 2002, Pages 1041-1048

  Shcherbik, Natalia ^a   Kumar, Sharad ^a   Haines, Dale S ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Nedd4; ole1; Rsp5; Spt23; WW domain

Indexed keywords

CALCIUM ION; COMPLEMENTARY DNA; LIPID BINDING PROTEIN; MUTANT PROTEIN; OLEIC ACID; PROTEASOME; PROTEIN PRECURSOR; RNA; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE ACTIVITY; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SUPPLEMENTATION; YEAST CELL;

CALCIUM-BINDING PROTEINS; CELLS, CULTURED; CYSTEINE; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; FATTY ACID DESATURASES; FUNGAL PROTEINS; HUMANS; LIGASES; MULTIENZYME COMPLEXES; MUTATION; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

MAMMALIA; SACCHAROMYCETALES;

EID: 0036501686     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4
2. Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5
3. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2
4. Rsp5 WW domains interact directly with the carboxyl-terminal domain of RNA polymerase II
5. Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis
6. Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae
7. Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+ channel subunits
8. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae
9. WW domains of Rsp5p define different functions: Determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiae
10. Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates
11. Nedd4-like proteins: An emerging family of ubiquitin protein ligases implicated in diverse cellular functions
12. All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+
13. Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease
14. The ubiquitin system
15. Gettin' down with ubiquitin: Turning off cell-surface receptors, transporters and channels
16. The conserved np14 protein complex mediates proteasome-dependent membrane-bound transcription factor activation
17. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome dependent processing
18. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
19. The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase
20. Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4
21. Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome
22. Function of WW domains as phosphoserine- or phosphothreonine-binding modules
23. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B
24. Nedd4 regulates ubiquitination and stability of the guanine nucleotide exchange factor CNrasGEF
25. Mechanisms underlying ubiquitination
26. The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization
27. Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb
28. C2-domains, structure and function of a universal Ca2+ binding domain
29. Ubiquitination and endocytosis of plasma membrane proteins: Role of Nedd4/Rsp5p family of ubiquitin-protein ligases
30. Ubiquitin is required for sorting to the vacuole of the yeast Gap1 permease
31. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome
32. Isolation and characterization of OLE1, a gene affecting fatty acid desaturation from Saccharomyces cerevisiae
33. NeW wrinkles for an old domain
34. Functional domains of the Rsp5 ubiquitin protein ligase
35. Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway
36. TAK1 is a ubiquitin-dependent kinase of MKK and IKK
37. Ubiquitin metabolism affects cellular response to volatile anesthetics in yeast
38. Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae
39. The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions
40. MGA2 or SPT23 is required for transcription of the delta9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae