메뉴 건너뛰기




Volumn 4, Issue 2, 1998, Pages 127-141

The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins

Author keywords

Chaperones; cis trans isomerase; Cyclophilin; Peptidyl prolyl; Pre mRNA splicing; SnRNP protein

Indexed keywords

CHAPERONE; CYCLOPHILIN; CYCLOSPORIN A; ISOMERASE; MESSENGER RNA PRECURSOR; SMALL NUCLEAR RIBONUCLEOPROTEIN;

EID: 0031916381     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (75)

References (58)
  • 2
    • 0023657312 scopus 로고
    • The influence of peptidyl-prolyl cis-trans isomerase on the in vitro folding of type III collagen
    • Bächinger HP. 1987. The influence of peptidyl-prolyl cis-trans isomerase on the in vitro folding of type III collagen. J Biol Chem 262:17144-17148.
    • (1987) J Biol Chem , vol.262 , pp. 17144-17148
    • Bächinger, H.P.1
  • 3
    • 0028143610 scopus 로고
    • The cyclophilin homolog Ninaa functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin
    • Baker EK, Colley NJ, Zuker CS. 1994. The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin. EMBO J 13:4886-4895.
    • (1994) EMBO J , vol.13 , pp. 4886-4895
    • Baker, E.K.1    Colley, N.J.2    Zuker, C.S.3
  • 5
    • 0029949799 scopus 로고    scopus 로고
    • Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription
    • Braaten D, Franke EK, Luban J. 1996. Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription. J Virol 70:3551-3560.
    • (1996) J Virol , vol.70 , pp. 3551-3560
    • Braaten, D.1    Franke, E.K.2    Luban, J.3
  • 6
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 7
    • 0021441197 scopus 로고
    • Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing
    • Bringmann P, Appel B, Rinke J, Reuter R, Theissen H, Lührmann R. 1984. Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing. EMBO J 3:1357-1363.
    • (1984) EMBO J , vol.3 , pp. 1357-1363
    • Bringmann, P.1    Appel, B.2    Rinke, J.3    Reuter, R.4    Theissen, H.5    Lührmann, R.6
  • 8
    • 0023782352 scopus 로고
    • Spliceosomal RNA U6 is remarkably conserved from yeast to mammals
    • Brow DA, Guthrie C. 1988. Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature 334:213-218.
    • (1988) Nature , vol.334 , pp. 213-218
    • Brow, D.A.1    Guthrie, C.2
  • 9
    • 0025821210 scopus 로고
    • Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing
    • Datta B, Weiner AM. 1991. Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing. Nature 352:821-824.
    • (1991) Nature , vol.352 , pp. 821-824
    • Datta, B.1    Weiner, A.M.2
  • 10
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam JD, Lebovitz RM, Roeder RG. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 11
  • 12
    • 0011757380 scopus 로고
    • Analytical ultracentrifugation
    • Rickwood D, ed. Oxford: IRL Press Ltd.
    • Eason R. 1984. Analytical ultracentrifugation. In: Rickwood D, ed. Centrifugation - A practical approach. Oxford: IRL Press Ltd. pp 251-287.
    • (1984) Centrifugation - A Practical Approach , pp. 251-287
    • Eason, R.1
  • 13
    • 0021668676 scopus 로고
    • Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides
    • Fischer G, Bang H, Mech C. 1984. Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides. Biomed Biochim Acta 43:1101-1111.
    • (1984) Biomed Biochim Acta , vol.43 , pp. 1101-1111
    • Fischer, G.1    Bang, H.2    Mech, C.3
  • 14
    • 0025260865 scopus 로고
    • The mechanism of protein folding. Implications of in vitro refolding models for de novo protein folding and translocation in the cell
    • Fischer G, Schmid FX. 1990. The mechanism of protein folding. Implications of in vitro refolding models for de novo protein folding and translocation in the cell. Biochemistry 29:2205-2212.
    • (1990) Biochemistry , vol.29 , pp. 2205-2212
    • Fischer, G.1    Schmid, F.X.2
  • 15
    • 0024959449 scopus 로고
    • Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
    • Fischer G, Wittmann-Liebold B, Lang K, Kiefhaber T, Schmid FX. 1989. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 337:476-478.
    • (1989) Nature , vol.337 , pp. 476-478
    • Fischer, G.1    Wittmann-Liebold, B.2    Lang, K.3    Kiefhaber, T.4    Schmid, F.X.5
  • 16
    • 0029372979 scopus 로고
    • The superfamily of arginine/serine-rich splicing factors
    • Fu XD. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1:663-680.
    • (1995) RNA , vol.1 , pp. 663-680
    • Fu, X.D.1
  • 17
    • 0027363385 scopus 로고
    • Peptidylproline cis-trans isomerases: Immunophilins
    • Galat A. 1993. Peptidylproline cis-trans isomerases: Immunophilins. Eur J Biochem 216:689-707.
    • (1993) Eur J Biochem , vol.216 , pp. 689-707
    • Galat, A.1
  • 18
    • 0026423013 scopus 로고
    • Messenger RNA splicing in yeast: Clues to why the spliceosome is a ribonucleoprotein
    • Guthrie C. 1991. Messenger RNA splicing in yeast: Clues to why the spliceosome is a ribonucleoprotein. Science 253:157-163.
    • (1991) Science , vol.253 , pp. 157-163
    • Guthrie, C.1
  • 19
    • 0003448569 scopus 로고
    • Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press
    • Harlow E, Lane DP. 1988. Antibodies. A laboratory manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
    • (1988) Antibodies. A Laboratory Manual
    • Harlow, E.1    Lane, D.P.2
  • 20
    • 0025373627 scopus 로고
    • Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: Evidence for the existence of a family of distinct enzymes
    • Harrison RK, Stein RL. 1990. Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: Evidence for the existence of a family of distinct enzymes. Biochemistry 29:3813-3816.
    • (1990) Biochemistry , vol.29 , pp. 3813-3816
    • Harrison, R.K.1    Stein, R.L.2
  • 21
    • 0021760292 scopus 로고
    • U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle
    • Hashimoto C, Steitz JA. 1984. U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle. Nucleic Acids Res 12:3283-3293.
    • (1984) Nucleic Acids Res , vol.12 , pp. 3283-3293
    • Hashimoto, C.1    Steitz, J.A.2
  • 22
    • 0029054377 scopus 로고
    • RNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions
    • Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R. 1995. RNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. EMBO J 14:2076-2088.
    • (1995) EMBO J , vol.14 , pp. 2076-2088
    • Hermann, H.1    Fabrizio, P.2    Raker, V.A.3    Foulaki, K.4    Hornig, H.5    Brahms, H.6    Lührmann, R.7
  • 23
    • 0031440025 scopus 로고    scopus 로고
    • A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs
    • Horowitz DS, Kobayashi R, Krainer AR. 1997. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. RNA 3:1374-1387.
    • (1997) RNA , vol.3 , pp. 1374-1387
    • Horowitz, D.S.1    Kobayashi, R.2    Krainer, A.R.3
  • 24
    • 0026342150 scopus 로고
    • Folding of chymotrypsin inhibitor 2.2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding
    • Jackson SE, Fersht AR. 1991. Folding of chymotrypsin inhibitor 2.2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding. Biochemistry 30:10436-10443.
    • (1991) Biochemistry , vol.30 , pp. 10436-10443
    • Jackson, S.E.1    Fersht, A.R.2
  • 25
    • 0027923620 scopus 로고
    • Role of U6 snRNA in 5′ splice site selection
    • Kandels-Lewis S, Séraphin B. 1993. Role of U6 snRNA in 5′ splice site selection. Science 262:2035-2039.
    • (1993) Science , vol.262 , pp. 2035-2039
    • Kandels-Lewis, S.1    Séraphin, B.2
  • 26
    • 0023665902 scopus 로고
    • An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
    • Kozak M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 15:8125-8148.
    • (1987) Nucleic Acids Res , vol.15 , pp. 8125-8148
    • Kozak, M.1
  • 27
    • 0029891101 scopus 로고    scopus 로고
    • The structure and function of proteins involved in mammalian pre-mRNA splicing
    • Krämer A. 1996. The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu Rev Biochem 65:367-409.
    • (1996) Annu Rev Biochem , vol.65 , pp. 367-409
    • Krämer, A.1
  • 28
    • 0027274978 scopus 로고
    • Cyclosporin A, FK506 and rapamycin: More than just immunosuppression
    • Kunz J, Hall MN. 1993. Cyclosporin A, FK506 and rapamycin: More than just immunosuppression. Trends Biochem Sci 18:334-338.
    • (1993) Trends Biochem Sci , vol.18 , pp. 334-338
    • Kunz, J.1    Hall, M.N.2
  • 29
    • 0030008174 scopus 로고    scopus 로고
    • Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs
    • Laggerbauer B, Lauber J, Lührmann R. 1996. Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs. Nucleic Acids Res 24:868-875.
    • (1996) Nucleic Acids Res , vol.24 , pp. 868-875
    • Laggerbauer, B.1    Lauber, J.2    Lührmann, R.3
  • 30
    • 0029782402 scopus 로고    scopus 로고
    • The HeLa 200kD U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases
    • Lauber J, Fabrizio P, Teigelkamp S, Lane WS, Hartmann E, Lührmann R. 1996. The HeLa 200kD U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. EMBO J 15:4001-4015.
    • (1996) EMBO J , vol.15 , pp. 4001-4015
    • Lauber, J.1    Fabrizio, P.2    Teigelkamp, S.3    Lane, W.S.4    Hartmann, E.5    Lührmann, R.6
  • 31
    • 0030749220 scopus 로고    scopus 로고
    • The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p
    • Lauber J, Plessel G, Prehn S, Will CL, Fabrizio P, Gröning K, Lane WS, Lührmann R. 1997. The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p. RNA 3:926-941.
    • (1997) RNA , vol.3 , pp. 926-941
    • Lauber, J.1    Plessel, G.2    Prehn, S.3    Will, C.L.4    Fabrizio, P.5    Gröning, K.6    Lane, W.S.7    Lührmann, R.8
  • 32
    • 0025027317 scopus 로고
    • Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5
    • Lehmeier T, Foulaki K, Lührmann R. 1990. Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5. Nucleic Acids Res 18:6475-6484.
    • (1990) Nucleic Acids Res , vol.18 , pp. 6475-6484
    • Lehmeier, T.1    Foulaki, K.2    Lührmann, R.3
  • 33
    • 0027739852 scopus 로고
    • Mutations in U6 snRNA that alter splice site specificity: Implications for the active site
    • Lesser CF, Guthrie C. 1993. Mutations in U6 snRNA that alter splice site specificity: Implications for the active site. Science 262:1982-1988.
    • (1993) Science , vol.262 , pp. 1982-1988
    • Lesser, C.F.1    Guthrie, C.2
  • 34
    • 0027207885 scopus 로고
    • Human immunodeficiency virus type 1 gag protein binds to cyclophilins A and B
    • Luban J, Bossolt KL, Franke EK, Kalpana GV, Goff SP. 1993. Human immunodeficiency virus type 1 gag protein binds to cyclophilins A and B. Cell 73:1067-1078.
    • (1993) Cell , vol.73 , pp. 1067-1078
    • Luban, J.1    Bossolt, K.L.2    Franke, E.K.3    Kalpana, G.V.4    Goff, S.P.5
  • 35
    • 0026486883 scopus 로고
    • A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome
    • Madhani HD, Guthrie C. 1992. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell 71:803-817.
    • (1992) Cell , vol.71 , pp. 803-817
    • Madhani, H.D.1    Guthrie, C.2
  • 36
    • 0028556367 scopus 로고
    • Dynamic RNA-RNA interactions in the spliceosome
    • Madhani HD, Guthrie C. 1994. Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genetics 28:1-26.
    • (1994) Annu Rev Genetics , vol.28 , pp. 1-26
    • Madhani, H.D.1    Guthrie, C.2
  • 39
    • 0027772159 scopus 로고
    • X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 Å resolution
    • Mikol V, Kallen J, Pflügl G, Walkinshaw MD. 1993. X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 Å resolution. J Mol Biol 234:1119-1130.
    • (1993) J Mol Biol , vol.234 , pp. 1119-1130
    • Mikol, V.1    Kallen, J.2    Pflügl, G.3    Walkinshaw, M.D.4
  • 40
    • 0028264022 scopus 로고
    • X-ray structure of a cyclophilin B/cyclosporin complex: Comparison with cyclophilin A and delineation of its calcineurin-binding domain
    • Mikol V, Kallen J, Walkinshaw MD. 1994. X-ray structure of a cyclophilin B/cyclosporin complex: Comparison with cyclophilin A and delineation of its calcineurin-binding domain. Proc Natl Acad Sci USA 91:5183-5186.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5183-5186
    • Mikol, V.1    Kallen, J.2    Walkinshaw, M.D.3
  • 41
    • 0001877802 scopus 로고
    • Splicing of precursors to messenger RNAs by the spliceosome
    • Gesteland RF, Atkins JE, eds. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press
    • Moore MJ, Query CC, Sharp PA. 1993. Splicing of precursors to messenger RNAs by the spliceosome. In: Gesteland RF, Atkins JE, eds. The RNA world. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. pp 303-357.
    • (1993) The RNA World , pp. 303-357
    • Moore, M.J.1    Query, C.C.2    Sharp, P.A.3
  • 43
    • 0028308696 scopus 로고
    • RNA-RNA interactions in the spliceosome: Unraveling the ties that bind
    • Nilsen TW. 1994. RNA-RNA interactions in the spliceosome: Unraveling the ties that bind. Cell 78:1-4.
    • (1994) Cell , vol.78 , pp. 1-4
    • Nilsen, T.W.1
  • 44
    • 0029885634 scopus 로고    scopus 로고
    • Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans
    • Page AP, MacNiven K, Hengartner MO. 1996. Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans. Biochem J 317:179-185.
    • (1996) Biochem J , vol.317 , pp. 179-185
    • Page, A.P.1    MacNiven, K.2    Hengartner, M.O.3
  • 45
    • 0030007060 scopus 로고    scopus 로고
    • The snRNP core assembly pathway: Identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro
    • Raker VA, Plessel G, Lührmann R. 1996. The snRNP core assembly pathway: Identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro. EMBO J 15:2256-2269.
    • (1996) EMBO J , vol.15 , pp. 2256-2269
    • Raker, V.A.1    Plessel, G.2    Lührmann, R.3
  • 46
    • 0028948314 scopus 로고
    • Cyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones Hsp70 and Hsp60
    • Rassow J, Mohrs K, Koidl S, Barhelmess IB, Pfanner N, Tropschug M. 1995. Cyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones Hsp70 and Hsp60. Mol Cell Biol 15:2654-2662.
    • (1995) Mol Cell Biol , vol.15 , pp. 2654-2662
    • Rassow, J.1    Mohrs, K.2    Koidl, S.3    Barhelmess, I.B.4    Pfanner, N.5    Tropschug, M.6
  • 47
    • 0022339931 scopus 로고
    • Localization of a base-paired interaction between small nuclear RNAs U4 and U6 in intact U4/U6 ribonucleoprotein particles by psoralen cross-linking
    • Rinke J, Appel B, Digweed M, Lührmann R. 1985. Localization of a base-paired interaction between small nuclear RNAs U4 and U6 in intact U4/U6 ribonucleoprotein particles by psoralen cross-linking. J Mol Biol 185:721-731.
    • (1985) J Mol Biol , vol.185 , pp. 721-731
    • Rinke, J.1    Appel, B.2    Digweed, M.3    Lührmann, R.4
  • 48
    • 0026453396 scopus 로고
    • Evidence for a base-pairing interaction between U6 small nuclear RNA and 5′ splice site during the splicing reaction in yeast
    • Sawa H, Abelson J. 1992. Evidence for a base-pairing interaction between U6 small nuclear RNA and 5′ splice site during the splicing reaction in yeast. Proc Natl Acad Sci USA 89:11269-11273.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11269-11273
    • Sawa, H.1    Abelson, J.2
  • 50
    • 0027739853 scopus 로고
    • The U5 and U6 small nuclear RNAs as active site components of the spliceosome
    • Sontheimer EJ, Steitz JA. 1993. The U5 and U6 small nuclear RNAs as active site components of the spliceosome. Science 262:1989-1996.
    • (1993) Science , vol.262 , pp. 1989-1996
    • Sontheimer, E.J.1    Steitz, J.A.2
  • 51
    • 0025968746 scopus 로고
    • Cyclosporin A slows collagen triple-helix formation in vitro: Indirect evidence for a physiologic role of peptidylprolyl cis-trans isomerase
    • Steinmann B, Bruchner P, Superti-Furga A. 1991. Cyclosporin A slows collagen triple-helix formation in vitro: Indirect evidence for a physiologic role of peptidylprolyl cis-trans isomerase. J Biol Chem 266:1299-1303.
    • (1991) J Biol Chem , vol.266 , pp. 1299-1303
    • Steinmann, B.1    Bruchner, P.2    Superti-Furga, A.3
  • 52
    • 0028917214 scopus 로고
    • A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing
    • Sun JS, Manley JL. 1995. A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing. Genes & Dev 9:843-854.
    • (1995) Genes & Dev , vol.9 , pp. 843-854
    • Sun, J.S.1    Manley, J.L.2
  • 53
    • 0024959451 scopus 로고
    • Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
    • Takahashi N, Hayano T, Suzuki M. 1989. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature 337:473-475.
    • (1989) Nature , vol.337 , pp. 473-475
    • Takahashi, N.1    Hayano, T.2    Suzuki, M.3
  • 55
    • 0026629246 scopus 로고
    • Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction
    • Walsh CT, Zydowsky LD, McKeon FD. 1992. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem 267:13115-13118.
    • (1992) J Biol Chem , vol.267 , pp. 13115-13118
    • Walsh, C.T.1    Zydowsky, L.D.2    McKeon, F.D.3
  • 56
    • 0026670431 scopus 로고
    • Interactions of small nuclear RNAs with precursor messenger RNA during in vitro splicing
    • Wassarman DA, Steitz JA. 1992. Interactions of small nuclear RNAs with precursor messenger RNA during in vitro splicing. Science 257:1918-1925.
    • (1992) Science , vol.257 , pp. 1918-1925
    • Wassarman, D.A.1    Steitz, J.A.2
  • 57
    • 0343907206 scopus 로고    scopus 로고
    • Protein functions in pre-mRNA splicing
    • Will CL, Lührmann R. 1997. Protein functions in pre-mRNA splicing. Curr Opin Cell Biol 9:320-328.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 320-328
    • Will, C.L.1    Lührmann, R.2
  • 58
    • 0025742986 scopus 로고
    • Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA
    • Wu J, Manley JL. 1991. Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA. Nature 352: 818-821.
    • (1991) Nature , vol.352 , pp. 818-821
    • Wu, J.1    Manley, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.