Serotonin antagonizes the human neuronal α7 nicotinic acetylcholine receptor and becomes an agonist after L248T α7 mutation

Neuroscience

Volumn 110, Issue 1, 2002, Pages 169-179

  Fucile, S ^a,b   Palma, E ^a,b   Eusebi, F ^a,b   Miledi, R ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Dipto di Scienze Internistiche   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Human 7 nAChR; Human threonine for leucine 248 7 nAChRs; Spontaneous nicotinic channels

Indexed keywords

ACETYLCHOLINE; ALPHA BUNGAROTOXIN; CALCIUM ION; CYSTEINE; MUTANT PROTEIN; NICOTINE; NICOTINIC RECEPTOR; SEROTONIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; MUTATION; NERVE CONDUCTION; NONHUMAN; OOCYTE; PERMEABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BLOCKING; TIME; WILD TYPE; XENOPUS;

ACETYLCHOLINE; ANIMALS; BINDING SITES; BRAIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; HUMANS; ION CHANNELS; MEMBRANE POTENTIALS; MUTATION; NEURONS; NICOTINE; NICOTINIC ANTAGONISTS; OOCYTES; RECEPTORS, NICOTINIC; SEROTONIN; SYNAPTIC MEMBRANES; SYNAPTIC TRANSMISSION; XENOPUS LAEVIS;

EID: 0036499464     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00567-X     Document Type: Article

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