IL-4 inhibits the production of TNF-α and IL-12 by STAT6-dependent and -independent mechanisms

Journal of Immunology

Volumn 162, Issue 9, 1999, Pages 5224-5229

  Levings, Megan K ^a,b   Schrader, John W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; STAT6 PROTEIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE PRODUCTION; FEMALE; IMMUNOREGULATION; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; DNA-BINDING PROTEINS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 0033136694     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Brennan, F. M., and M. Feldmann. 1996. Cytokines in autoimmunity. Curr. Opin. Immunol. 8:872.
2. Hart, P. H., G. F. Vitti, D. R. Burgess, G. A. Whitty, D. S. Piccoli, and J. A. Hamilton. 1989. Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor α, interleukin 1, and prostaglandin E2. Proc. Natl. Acad. Sci. USA 86:3803.
3. Wang, P., P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah. 1995. Interleukin (IL)-10 inhibits nuclear factor κB (NF κE) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J. Biol. Chem. 270:9558.
4. Mijatovic, T., V. Kruys, D. Caput, P. Defrance, and G. Huez. 1997. Interleukin-4 and -13 inhibit tumor necrosis factor-α mRNA translational activation in lipopolysaccharide-induced mouse macrophages. J. Biol. Chem. 272:14394.
5. Abramson, S. L., and J. I. Gallin. 1990. IL-4 inhibits Superoxide production by human mononuclear phagocytes. J. Immunol. 144:625.
6. te Velde, A. A., R. J. Huijbens, J. E. de Vries, and C. G. Figdor. 1990. IL-4 decreases FcγR membrane expression and FcγR-mediated cytotoxic activity of human monocytes. J. Immunol. 144:3046.
7. Gautam, S., J. M. Tebo, and T. A. Hamilton. 1992. IL-4 suppresses cytokine gene expression induced by IFN-γ and/or IL-2 in murine peritoneal macrophages. J. Immunol. 148:1725.
8. Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler. 1996. Regulation of murine macrophage IL-12 production: activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol. 156:1196.
9. + T cells. J. Immunol. 154:5071.
10. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stato in IL-4 signalling. Nature 380:627.
11. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, et al. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stato gene. Nature 380:630.
12. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity A:313.
13. Kuperman, D., B. Schofield, M. Wills-Karp, and M. J. Grusby. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187:939.
14. Akimoto, T., F. Numata, M. Tamura, Y. Takata, N. Higashida, T. Takashi, K. Takeda, and S. Akira. 1998. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 187:1537.
15. Takeda, K., H. Tsutsui, T. Yoshimoto, O. Adachi, N. Yoshida, T. Kishimoto, H. Okamura, K. Nakanishi, and S. Akira. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8:383.
16. Read, M. A., M. Z. Whitley, A. J. Williams, and T. Collins. 1994. NF-κB and IicBa: an inducible regulatory system in endothelial activation. J. Exp. Med. 179:503.
17. Collart, M. A., P. Baeuerle, and P. Vassalli. 1990. Regulation of tumor necrosis factor a transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol. Cell. Biol. 10:1498.
18. Hayes, M. P., S. L. Freeman, and R. P. Donnelly. 1995. IFN-γ priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and MRNA stability. Cytokine 7:427.
19. Essner, R., K. Rhoades, W. H. McBride, D. L. Morton, and J. S. Economou. 1989. IL-4 down-regulates IL-1 and TNF gene expression in human monocytes. J. Immunol. 142:3857.
20. de Waal Malefyt, R., C. G. Figdor, R. Huijbens, S. Mohan-Peterson, B. Bennett, J. Culpepper, W. Dang, G. Zurawski, and J. E. de Vries. 1993. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-γ or IL-10. J. Immunol. 151:6370.
21. Hayes, M. P., J. Wang, and M. A. Norcross. 1995. Regulation of interleukin-12 expression in human monocytes: selective priming by inteiferon-γ of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646.
22. D'Andrea, A., X. Ma, M. Aste-Amezaga, C. Paganin, and G. Trinchieri. 1995. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor α production. J. Exp. Med. 181:537.
23. Aste-Amezaga, M., X. Ma, A. Sartori, and G. Trinchieri. 1998. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J. Immunol. 160: 5936.
24. Welham, M. J., H. Bone, M. Levings, L. Learmonth, L. M. Wang, K. B. Leslie, J. H. Pierce, and J. W. Schrader. 1997. Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells. J. Biol. Chem. 272:1377.
25. te Velde, A. A., R. J. Huijbens, K. Heije, J. E. de Vries, and C. G. Figdor. 1990. Interleukin-4 (IL-4) inhibits secretion of IL-1β, tumor necrosis factor α, and IL-6 by human monocytes. Blood 76:1392.
26. Trinchieri, G. 1997. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ). Curr. Opin. Immunol. 9:17.
27. Wang, P., P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah. 1994. IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J. Immunol. 153:811.
28. Kotanides, H., and N. C. Reich. 1996. Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J. Biol. Chem. 271:25555.
29. Kaplan, M. H., C. Daniel, U. Schindler, and M. J. Grusby. 1998. Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol. Cell. Biol. 18:1996.
30. Ohmori, Y., and T. A. Hamilton. 1997. IL-4-induced STAT6 suppresses IFN-γ-stimulated STAT1-dependent transcription in mouse macrophages. J. Immunol. 159:5474.
31. Dickensheets, H. L., and R. P. Donnelly. 1997. IFN-γ and IL-10 inhibit induction of IL-1 receptor type I and type II gene expression by IL-4 and IL-13 in human monocytes. J. Immunol. 159:6226.
32. Oswald, I. P., R. T. Gazzinelli, A. Sher and S. L. James. 1992. IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity. J. Immunol. 148:3578.
33. Donnelly, R. P., L. J. Crofford, S. L. Freeman, J. Buras, E. Remiers, R. L. Wilder, and M. J. Fenton. 1993. Tissue-specific regulation of IL-6 production by IL-4: differential effects of IL-4 on nuclear factor-κB activity in monocytes and fibroblasts. J. Immunol. 151:5603.
34. Bennett, B. L, R. Cruz, R. G. Lacson, and A. M. Manning. 1997. Interleukin-4 suppression of tumor necrosis factor a-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-κB. J. Biol. Chem. 272:10212.
35. Standiford, T. J., T. Lindsten, C. B. Thompson, R. M. Strieter, and S. L. Kunkel. 1992. Interleukin-4 differentially regulates tumor necrosis factor-α gene expression by human T lymphocytes and monocytes. Pathobiology 60:100.
36. Rhoades, K. L., S. Cai, S. H. Golub, and J. S. Economou. 1995. Granulocytemacrophage colony-stimulating factor and interleukin-4 differentially regulate the human tumor necrosis factor-α promoter region. Cell. Immunol. 161:125.
37. Ohmori, Y., M. F. Smith, Jr., and T. A. Hamilton. 1996. IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6. J. Immunol. 157: 2058.
38. Paul, W. E. 1991. Interleukin-4: A prototypic immunoregulatory lymphokine. Blood 77:1859.
39. Kambayashi, T., C. O. Jacob, and G. Strassmann. 1996. IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulated murine peritoneal mononuclear phagocytes. Cell. Immunol. 171:153.
40. Nicholson, S. E., and D. J. Hilton. 1998. The SOCS proteins: a new family of negative regulators of signal transduction. J. Leukocyte Biol. 63:665.
41. Liu, B., J. Liao, X. Rao, S. A. Kushner, C. D. Chung, D. D. Chang, and K. Shuai. 1998. Inhibition of Stall-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA 95:10626.
42. Seidel, H. M., L. H. Milocco, P. Lamb, J. E. Darnell, Jr., R. B. Stein, and J. Rosen. 1995. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA 92:3041.