Neuroprotective effect of apolipoprotein E against ischemia

Annals of the New York Academy of Sciences

Volumn 977, Issue , 2002, Pages 468-475

  Kitagawa, Kazuo ^a   Matsumoto, Masayasu ^b   Hori, Masatsugu ^a   Yanagihara, Takehiko ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Apolipoprotein E (APOE); Apoptosis; Cerebral ischemia; Free radical; Glutamate

Indexed keywords

APOLIPOPROTEIN E; FREE RADICAL; GLUTAMIC ACID; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT; STAUROSPORINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; BRAIN ISCHEMIA; CELL DEATH; CELL SELECTION; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; KNOCKOUT MOUSE; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN DEFICIENCY; LIPOPROTEIN METABOLISM; MALE; MOLECULAR MECHANICS; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OBSERVATION; PEROXIDATION; STATISTICAL SIGNIFICANCE; WILD TYPE;

ANIMALIA;

EID: 0036449618     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04852.x     Document Type: Conference Paper

References (34)

1. Laskowitz, D.T., H. Sheng, R. Bart et al. 1997. Apolipoprotein E deficient mice have increased susceptibility to focal cerebral ischemia. J. Cereb. Blood Flow Metab. 17: 753-758.
2. Horsburgh, K., S. Kelly, J. McCulloch et al. 1999. Increased neuronal damage in apolipoprotein E-deficient mice following global ischemia. Neuroreport 10: 837-841.
3. Sheng, H., D.T. Laskowitz, G.B. Mackensen et al. 1999. Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse. Stroke 30: 1118-1124.
4. Horsburgh, K., J. McCulloch, M. Nilsen et al. 2000. Intraventricular infusion of apolipoprotein E ameliorates acute neuronal damage after global cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 20: 458-462.
5. Sheng, H., D.T. Laskowitz, E. Bennet et al. 1998. Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. J. Cereb. Blood Flow Metab. 18: 361-366.
6. Dirnagl, U., C. Iadecolla & M.A. Moskowitz. 1999. Pathobiology of ischemic stroke: An integrated view. Trends Neurosci. 22: 391-397.
7. Rothman, S.M. & J.W. Olney. 1986. Glutamate and the pathophysiology of hypoxic-ischemia brain damage. Ann. Neurol. 19: 105-111.
8. Hossman, K.A. 1994. Glutamate-mediated injury in focal cerebral ischemia: The excitotoxin hypothesis revised. Brain Pathol. 4: 23-36.
9. Choi, D.W. 1995. Calcium: Still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. 18: 58-60.
10. Chan, P.H. 2001. Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow Metab. 21: 2-14.
11. Linnik, M.D., R.H. Zobrist & M.D. Hatfield. 1993. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24: 2002-2008.
12. Nitatori, T., N. Sato, S. Waguri et al. 1995. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J. Neurosci. 15: 1001-1011.
13. Petito, C.K., J. Torres-Munoz, B. Roberts et al. 1997. DNA fragmentation follows delayed neuronal death in CA1 neurons exposed to transient global ischemia in the rat. J. Cereb. Blood Flow Metab. 17: 967-976.
14. Colbourne, F., G.R. Sutherland & R.N. Auer. 1999. Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia. J. Neurosci. 19: 4200-4210.
15. Zhang, S.H., R.L. Reddick, J.A. Piedrahita & N. Maeda. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258: 468-471.
16. Chen, B. & M.P. Mattson. 1994. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res. 640: 56-67.
17. Kitagawa, K., M. Matsumoto, Y. Tsujimoto et al. 1998. Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice. Stroke 29: 2616-2621.
18. Hall, E.D., J. Oostveen, E. Dunn & D.B. Carter. 1995. Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils. Exp. Neurol. 135: 17-27.
19. Kida, E., R. Pluta, A.S. Lossinsky et al. 1995. Complete cerebral ischemia with short term survival in rat induced by cardiac arrest: II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain. Brain Res. 674: 341-346.
20. Horsburgh, K. & J.A.R. Nicoll. 1996. Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischemia in the rat. Neuropathol. Appl. Neurobiol. 22: 342-349.
21. Ishimaru, H., K. Ishikawa et al. 1996. Cystatin C and apolipoprotein E immunoreactivities in CA1 neurons in ischemic gerbil hippocampus. Brain Res. 709: 155-162.
22. Ali, S.M., E. Dunn, J. Oostveen et al. 1996. Induction of apolipoprotein E mRNA in the hippocampus of the gerbil after transient global ischemia. Mol. Brain Res. 38: 37-44.
23. Kitagawa, K., M. Matsumoto, K. Kuwabara et al. 2001. Delayed, but marked, expression of apolipoprotein E is involved in tissue clearance after cerebral infarction. J. Cereb. Blood Flow Metab. 21: 1199-1207.
24. Koh, J.Y., M.B. Wie, B.J. Gwag et al. 1995. Staurosporine-induced neuronal apoptosis. Exp. Neurol. 135: 153-159.
25. Lendon, C.L., B.H. Han, K. Salimi et al. 2000. No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischemia in vivo. Eur. J. Neurosci. 12: 2235-2242.
26. Peters, O., T. Back, U. Lindauer et al. 1998. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 18: 196-205.
27. Miyata, M. & J.D. Smith. 1996. Apolipoprotein E allele-specific antioxidant activity and effects of cytotoxicity by oxidative insults and β-amyloid peptides. Nat. Genet. 14: 55-61.
28. Pedersen, W.A., S.L. Chan & M.P. Mattson. 2000. A mechanism for the neuroprotective effect of apolipoprotein E: Isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J. Neurochem. 74: 1426-1433.
29. Ramassamy, C., P. Krzywkowski, D. Averill et al. 2001. Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain. Mol. Brain Res. 86: 76-83.
30. Hara, H., H. Kato & K. Kogure. 1990. Protective effect of alpha-tocopherol on ischemic neuronal damage in the gerbil hippocampus. Brain Res. 510: 335-338.
31. Pratico, D., R.K. Tangirala, D.J. Rader et al. 1998. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat. Med. 10: 1189-1192.
32. de Sarno, P. & R.S. Jope. 1998. Phosphoinositide hydrolysis activated by muscarinic or glutamatergic, but not adrenergic, receptors is impaired in ApoE-deficient mice and by hydrogen peroxide and peroxynitrite. Exp. Neurol. 152: 123-128.
33. Lomnitski, L., L. Oron, D. Sklan & D.M. Michaelson. 1999. Distinct alterations in phospholipid metabolism in brains of apolipoprotein E-deficient mice. J. Neurol. Res. 58: 586-592.
34. Lomnitski, L., A. Nyska, E. Shohami et al. 2000. Increased levels of intracellular iron in the brains of ApoE-deficient mice with closed head injury. Exp. Toxicol. Pathol. 52: 177-183.