Phosphoinositide hydrolysis activated by muscarinic or glutamatergic, but not adrenergic, receptors is impaired in apoE-deficient mice and by hydrogen peroxide and peroxynitrite

Experimental Neurology

Volumn 152, Issue 1, 1998, Pages 123-128

  De Sarno, Patrizia ^a   Jope, Richard S ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Alzheimer's disease; Apolipoprotein E; Hydrogen peroxide; Oxidative stress; Peroxynitrite; Phosphoinositide hydrolysis

Indexed keywords

ADRENERGIC RECEPTOR; APOLIPOPROTEIN E; GLUTAMATE RECEPTOR; HYDROGEN PEROXIDE; MUSCARINIC RECEPTOR; PEROXYNITRITE; PHOSPHATIDYLINOSITIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; HYDROLYSIS; MOUSE; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 0031820212     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6825     Document Type: Article

References (29)

1. Anderson, R., and G. A. Higgins. 1997. Absence of central cholinergic deficits in APOE knockout mice. Psycopharmacology (Berlin) 132: 135-144.
2. Bartus, R. T., R. L. Dean, B. Beer, and A. S. Lippa. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408-414.
3. Bashir, Z. I., Z. A. Bortolotto, C. H. Davies, N. Berretta, A. J. Irving, A. J. Seal, J. M. Henley, D. E. Jane, J. C. Watkins, and G. L. Collingridge. 1993. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature 363: 347-350.
4. Beckman, J. S., J. Chen, H. Ischiropoulos, and J. P. Crow. 1994. Oxidative chemistry of peroxynitrite. Methods Enzymol. 233: 229-240.
5. Blusztajn, J. K., and R. J. Wurtman. 1983. Choline and cholinergic neurons. Science 221: 614-620.
6. Bortolotto, Z. A., and G. L. Collingridge. 1993. Characterization of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus. Neuropharmacology 32: 1-9.
7. Chen, Y., L. Lomnitski, D. M. Michaelson, and E. Shohami. 1997. Motor and memory deficits in apoE-deficient mice after closed head injury. Neuroscience 80: 1255-1262.
8. Corder, E. H., A. M. Saunders, W. J. Strittmatter, D. E. Schmechel, P. C. Gaskell, G. W. Small, A. D. Roses, J. L. Haines, and M. A. Pericak-Vance. 1993. Gene dosage of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-923.
9. Fisher, S. K. 1995. Homologous and heterologous regulation of receptor-stimulated phosphoinositide hydrolysis. Eur. J. Pharmacol. 288: 231-250.
10. Gordon, I., E. Grauer, I. Genis, E. Sehayek, and D. M. Michaelson. 1995. Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice. Neurosci. Lett. 199: 1-4.
11. Halliwell, B. 1992. Reactive oxygen species and the central nervous system. J. Neurochem. 59: 1609-1623.
12. Hayek, T., J. Oiknine, J. G. Brook, and M. Aviram. 1994. Role of HDL apolipoprotein E in cellular cholesterol efflux : Studies in apoE knockout transgenic mice. Biochem. Biophys. Res. Commun. 205: 1072-1078.
13. Jope, R. S. 1996. Cholinergic muscarinic receptor signaling by the phosphoinositide signal transduction system in Alzheimer's disease. Alzheimer's Dis. Rev. 1: 2-14.
14. Jope, R. S., L. Song, and R. E. Powers. 1997. Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain. Neurobiol. Aging 18: 111-120.
15. Kelly, J. F., K. Furukawa, S. W. Barger, M. R. Rengen, R. J. Mark, E. M. Banc, G. S. Roth, and M. P. Mattson. 1996. Amyloid beta-peptide disrupts carbachol- induced muscarinic cholinergic signal transduction in cortical neurons. Proc. Natl. Acad. Sci. USA 93: 6753-6758.
16. Li, X., L. Song, and R. S. Jope. 1996. Cholinergic stimulation of AP-1 and NFkB transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: Relationship to phosphoinositide hydrolysis. J. Neurosci. 16: 5914-5922.
17. Lomnitski, L., R. Kohen, Y. Chen, E. Shohami, V. Trembovler, T. Vogel, and D. M. Michaelson. 1997. Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury. Pharm. Biochem. Behavior 56: 669-673.
18. Mahley, R. W. 1988. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240: 622-630.
19. Markesbery, W. R. 1997. Oxidative stress hypothesis in Alzheimer's disease. Free Rad. Biol. Med. 23: 134-147.
20. Masliah, E., M. Mallory, I. Veinbergs, A. Miller, and W. Samuel. 1995. Alteration in apolipoprotein E expression during aging and neurodegeneration. Prog. Neurobiol. 50: 493-503.
21. Masliah, E., W. Samuel, I. Veinbergs, M. Mallory, M. Mante, and T. Saitoh. 1997. Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE. Brain Res. 751: 307-314.
22. Miyata, M., and J. D. Smith. 1996. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nature Gen. 14: 55-61.
23. Oitzl, M. S., M. Mulder, P. J. Lucassen, L. M. Havekes, J. Grootendorst, and E. R. De Kloet. 1997. Severe learning deficits in apolipoprotein E-knockout mice in a water maze task. Brain Res. 752: 189-196.
24. Pacheco, M. A., and R. S. Jope. 1996. Phosphoinositide signaling in human brain. Prog. Neurobiol. 50: 255-273.
25. Palinski, W., V. A. Ord, A. S. Plump, J. L. Breslow, D. Steinberg, and J. L. Witztum. 1994. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arteriosclerosis Thrombosis 14: 605-616.
26. Poirier, J. Apolipoprotein E in animal models of CNS injury and Alzheimer's disease. 1994. Trends Neurosci. 17: 525-530.
27. Poirier, J., M-C. Delisle, R. Quirion, I. Aubert, M. Farlow, D. Lahiri, S. Hui, P. Bertrand, J. Nalbantoglu, B. M. Gilfix, and S. Gauthier. 1995. Apolipoprotein E allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 92: 12260-12264.
28. Roses, A. D. 1996. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu. Rev. Med. 47: 387-400.
29. Soininen, H., O. Kosunen, S. Helisalmi, A. Mannermaa, L. Paljarvi, S. Talasniemi, M. Ryynanen, and P. Riekkinen S. R. 1995. A severe loss of choline acetyltranferase in the frontal cortex of Alzheimer patients carrying apolipoprotein ∈4 allele. Neurosci. Lett. 187: 79-82.