Distinct alterations in phospholipid metabolism in brains of apolipoprotein E-deficient mice

Journal of Neuroscience Research

Volumn 58, Issue 4, 1999, Pages 586-592

  Lomnitski, L ^a   Oron, L ^a   Sklan, D ^b   Michaelson, D M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Alzheimer's disease; Apolipoprotein E; Apolipoprotein E deficient mice; Brain; Fatty acids; Phospholipids

Indexed keywords

APOLIPOPROTEIN E; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; HYPERLIPOPROTEINEMIA TYPE 3; LIPID ANALYSIS; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; TISSUE LEVEL; TISSUE PREPARATION;

EID: 0033571640     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19991115)58:4<586::AID-JNR11>3.0.CO;2-7     Document Type: Article

References (31)

1. Agranoff BW. 1989. Lipids. In: Siegel GJ, et al., editors. Basic neurochemistry: molecular, cellular and medical aspects. New York: Raven Press Ltd. p 91-107.
2. Chapman S, Michaelson DM. 1998. Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice. J. Neurochem 70:708-714.
3. Chen Y, Lomnitski L, Michaelson DM, Shohami E. 1997. Motor and memory deficits in apoE-deficient mice after closed head injury. Neuroscience 30:1255-1262.
4. Farooqui AA, Wells K, Horrocks LA. 1995. Breakdown of membrane phospholipids in Alzheimer's disease. Involvement of excitatory amino acid receptors. Mol Chem Neuropathol 25:155-173.
5. Folch J, Lees M, Stanley GHS. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509.
6. Genis I, Gordon I, Sehayek E, Michaelson DM. 1995. Phosphorylation of tau in apolipoprotein E-deficient mice. Neurosci Lett 199: 5-8.
7. Genis I, Fisher A, Michaelson DM. 1999. Site specific dephosphorylation of tau of apoE-deficient mice and control mice by M1 muscarinic agonist treatment. J Neurochem (in press).
8. Ginsberg L, Atack JR, Rapoport SI, Gershfield NL. 1993. Evidence for a membrane lipid defect in Alzheimer's disease. Mol Chem Neuropathol 19:37-46.
9. Gottfries CG, Karlsson I, Svennerholm L. 1996. Membrane components separate early-onset Alzheimer's disease from senile dementia of the Alzheimer type, Int Psychogeriatr 8:365-372.
10. 3H]arachidonic acid from blood in rat brain synaptosomal fractions before and after cholinergic stimulation. J Neurochem 67: 822-829.
11. Lomnitski L, Kohen R, Chen Y, Shohami E, Trembovler V, Vogel T, Michaelson DM. 1997. Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury. Pharmacol Biochem Behav 56:669-673.
12. Lomnitski L, Chapman S, Hochman A, Kohen R, Shohami E, Chen Y, Trembovler V, Michaelson DM. 1999a. Antioxidant mechanisms in apolipoprotein E-delicient mice prior to and following closed head injury. Biochim Biophys Acta 1453:359-368.
13. Lomnitski L, Nyska A, Shohami E, Chen Y, Michaelson DM. 1999b. Apolipoprotein E-deficient mice are more susceptible to closed head injury: a comparative histopathological evaluation of apoE-deticient and control mice. Toxicol Pathol 26:834.
14. Mahley RW, Nathan BP, Pitas RE. 1996. Apolipoprotein E structure, function and possible roles in Alzheimer's disease. In: Wurtman RJ, Corkin S, Growdon JH, Nitsch RM, editors. The neurobiology of Alzheimer's disease. New York: New York Academy of Sciences, p 139-145.
15. Masliah E, Mallory M, Ge N, Alford M, Veinberg I, Roses AD. 1995. Neurodegeneration in the central nervous system of apoE-deficient mice. Exp Neurol 136:107-122.
16. Matthews RT, Beal MF. 1996. Increased 3-nitrotyrosine in brains of apoE-deficient mice. Brain Res 718:181-184.
17. McGee CD, Greenwood CE, Cinader B. 1994. Dietary fat composition and age affect synaptosomal and retinal phospholipid fatty acid composition in C57BL/6 mice. Lipids 29:605-610.
18. Meiri G, Shibolet A, Michaelson DM. 1998. Isoform specific effects of apolipoprotein E on neuronal phospholipid biosynthesis. Neurosci Lett 51:19S.
19. Nakada T, Kwee IL, Ellis WG. 1990. Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease. Neuroreport 1:153-155.
20. 4 on neuronal growth in vitro. Science 264:850-852.
21. Nitsch R, Pittas A, Blusztajn JK, Slack BE, Growdon JH, Wartman RJ. 1991. Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease. Ann NY Acad Sci 640:110-113.
22. Plump AS, Smith JD, Hayek T, Aalto-Stala K, Walsh A, Verstuygg JG, Rubin M, Breslow JL. 1992. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 16:343-353.
23. Poirier J. 1995. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 17:525-530.
24. Roses AD. 1994. Apolipoprotein E affects the rate of Alzheimer's disease expression: beta-amyloid burden is a secondary consequence dependent on apoE genotype and duration of disease. J Neuropathol Exp Neurol 53:429-431.
25. Sheng H, Laskowitz DT, Bennet E, Schmechel DE, Bart RD, Saunders AM, Pearlstein RD, Roses AD, Warner DS. 1998. Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. J Cereb Blood Flow Metab 18:361-366.
26. Sklan D, Hurwitz S, Budowski P, Ascarelli I. 1975. Fat digestion and absorption in chicks fed raw or heated soybean meal. J Nutr 105:57-63.
27. Soderberg M, Edlung K, Kristensson K, Dallner G. 1991. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 26:421-425.
28. Soderberg M, Edlund C, Alafuzoff I, Kristensson K, Dallner G. 1992. Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type. J Neurochem 59:1646-1653.
29. Svennerholm L, Gottfries C. 1994. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II) J Neurochem 62:1039-1047.
30. Tronchere H, Record M, Francois T, Chap H. 1994. Phosphatidylcholine cycle and regulation of phosphatidylcholine biosynthesis by enzyme translocation. Biochim Biophys Acta 1212:137-151.
31. Wells K, Farooqui AA, Liss L, Horrocls LA. 1995. Neural membrane phospholipids in Alzheimer's disease. Neurochem Res 20:1329-1333.