Desnitro-imidacloprid activates the extracellular signal-regulated kinase cascade via the nicotinic receptor and intracellular calcium mobilization in N1E-115 cells

Toxicology and Applied Pharmacology

Volumn 184, Issue 3, 2002, Pages 180-186

  Tomizawa, Motohiro ^a   Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Desnitro imidacloprid; Extracellular signal regulated kinase (ERK); Imidacloprid; Intracellular Ca2+; Mitogen activated protein kinase (MAPK); N1E 115 cells; Neonicotinoid insecticide; Nicotine; Nicotinic receptor

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACID TETRAKIS(ACETOXYMETHYL)ESTER; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 AMINOETHOXYDIPHENYLBORANE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ALPHA BUNGAROTOXIN; ATROPINE; BORIC ACID; CALCIUM; CALCIUM CHELATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; DESNITROIMIDACLOPRID; EGTAZIC ACID; IMIDACLOPRID; INOSITOL 1,4,5 TRISPHOSPHATE; MECAMYLAMINE; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NICOTINE; NICOTINIC RECEPTOR; PHOSPHOLIPASE C; PROTEIN KINASE C; RYANODINE; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INCUBATION TIME; METABOLITE; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 0036445812     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9503     Document Type: Article

References (43)

1. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., and Saltiel, A. R. (1995). PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270, 27489-27494.
2. Barrantes, G. E., Murphy, C. T., Westwick, J., and Wonnacott, S. (1995). Nicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels. Neurosci. Lett. 196, 101-104.
3. Berridge, M. J. (1998). Neuronal calcium signaling. Neuron 21, 13-26.
4. Bleasdale, J. E., Thakur, N. R., Gremban, R. S., Bundy, G. L., Fitzpatrick, F. A., Smith, R. J., and Bunting, S. (1990). Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J. Pharmacol. Exp. Ther. 255, 756-768.
5. Chijiwa, T., Mishima, A., Hagiwara, M., Sano, M., Hayashi, K., Inoue, T., Naito, K., Toshioka, T., and Hidaka, H. (1990). Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC 12D pheochromocytoma cells. J. Biol. Chem. 265, 5267-5272.
6. Cordero-Erausquin, M., Marubio, L. M., Klink, R., and Changeux, J-P. (2000). Nicotinic receptor function: New perspectives from knockout mice. Trends Pharmacol. Sci. 21, 211-217.
7. Corringer, P.-J., Le Novère, N., and Changeux, J.-P. (2000). Nicotinic receptors at the amino acid level. Annu. Rev. Pharmacol. Toxicol. 40, 431- 458.
8. Cox, M. E., and Parsons, S. J. (1997). Roles for protein kinase C and mitogen-activated protein kinase in nicotine-induced secretion from bovine adrenal chromaffin cells. J. Neurochem. 69, 1119-1130.
9. Dajas-Bailador, F. A., Soliakov, L., and Wonnacott, S. (2002). Nicotine activates the extracellular signal-regulated kinase 1/2 via the α7 nicotinic acetylcholine receptor and protein kinase A, in SH-SY5Y cells and hippocampal neurones. J. Neurochem. 80, 520-530.
10. Dineley, K. T., Westerman, M., Bui, D., Bell, K., Ashe, K. H., and Sweatt, J. D. (2001). β-Amyloid activates the mitogen-activated protein kinase cascade via hippocampal α7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21, 4125-4133.
11. 2+-release channels. Trends Pharmacol. Sci. 15, 145-149.
12. English, J. M., and Cobb, M. H. (2002). Pharmacological inhibitors of MAPK pathways. Trends Pharmacol. Sci. 23, 40-45.
13. Grewal, S. S., York, R. D., and Stork, P. J. S. (1999). Extracellular-signal-regulated kinase signalling in neurons. Curr. Opin. Neurobiol. 9, 544-553.
14. Jefferies, P. R., Blumenkopf, T. A., Gengo, P. J., Cole, L. C., and Casida, J. E. (1996). Ryanodine action at calcium release channels. 1. Importance of hydroxyl substituents. J. Med. Chem. 39, 2331-2338.
15. Kagabu, S. (1997). Chloronicotinyl insecticides: Discovery, application and future perspective. Rev. Toxicol. 1, 75-129.
16. Lloyd, G. K., and Williams, M. (2000). Neuronal nicotinic acetylcholine receptors as novel drug targets. J. Pharmacol. Exp. Ther. 292, 461-467.
17. 2+ channels. Science 287, 1647-1651.
18. Marais, R., Light, Y., Mason, C., Paterson, H., Olson, M. F., and Marshall, C. J. (1998). Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280, 109-112.
19. 2+ release. J. Biochem. 122, 498-505.
20. 2+ signaling. Curr. Opin. Neurobiol. 7, 339-345.
21. Pearson, G., Robinson, F., Gibson, T. B., Xu, B.-E., Karandikar, M., Berman, K., and Cobb, M. H. (2001). Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr. Rev. 22, 153-183.
22. Pettmann, B., and Henderson, C. E. (1998). Neuronal cell death. Neuron 20, 633-647.
23. Rathouz, M. M., and Berg, D. K. (1994). Synaptic-type acetylcholine receptors raise intracellular calcium levels in neurons by two mechanisms. J. Neurosci. 14, 6935-6945.
24. Roberson, E. D., English, J. D., Adams, J. P., Selcher, J. C., Kondratick, C., and Sweatt, J. D. (1999). The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP responsible element binding protein phosphorylation in area CA1 of hippocampus. J. Neurosci. 19, 4337-4348.
25. Roberts T. R., and Hutson D. H. (Eds.) (1999). Metabolic Pathways of Agrochemicals, Part 2: Insecticides and Fungicides. The Royal Society of Chemistry, Cambridge, UK.
26. Schaeffer, H. J., and Weber, M. J. (1999). Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol. Cell. Biol. 19, 2435-2444.
27. Schulz-Jander, D. A., Leimkuehler, W. M., and Casida J. E. (2002). Neonicotinoid insecticides: Reduction and cleavage of imidacloprid nitroimine substituent by liver microsomal and cytosolic enzymes. Chem. Res. Toxicol. 15, 1158-1165.
28. 2+ signaling. Trends Pharmacol. Sci. 22, 459-464.
29. 2+ in the cytosol. Biochem. J. 344, 39-46.
30. Sweatt, J. D. (2001). The neuronal MAP kinase cascade: A biochemical signal integration system subserving synaptic plasticity and memory. J. Neurochem. 76, 1-10.
31. Tang, K., Wu, H., Mahata, S. K., and O'Connor, D. T. (1998). A critical role for the mitogen-activated protein kinase pathway in nicotinic cholinergic signaling to secretory protein transcription in pheochromocytoma cells. Mol. Pharmacol. 54, 59-69.
32. Tomizawa, M., and Casida, J. E. (1999). Minor structural changes in nicotinoid insecticides confer differential subtype selectivity for mammalian nicotinic acetylcholine receptors. Br. J. Pharmacol. 127, 115-122.
33. Tomizawa, M., and Casida, J. E. (2000). Imidacloprid, thiacloprid, and their imine derivatives up-regulate the α4β2 nicotinic acetylcholine receptor in M10 cells. Toxicol. Appl. Pharmacol. 169, 114-120.
34. Tomizawa, M., Lee, D. L., and Casida, J. E. (2000). Neonicotinoid insecticides: Molecular features conferring selectivity for insect versus mammalian nicotinic receptors. J. Agric. Food Chem. 48, 6016-6024.
35. Tomizawa, M., Cowan, A., and Casida, J. E. (2001). Analgesic and toxic effects of neonicotinoid insecticides in mice. Toxicol. Appl. Pharmacol. 177, 77-83.
36. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., Loriolle F., Duhamel, L., Charon, D., and Kirilovsky, J. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 15771-15781.
37. Traverse, S., Gomez, N., Paterson, H., Marshall, C., and Cohen, P. (1992). Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells: Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288, 351-355.
38. Tripathi, H. L., Martin, B. R., and Aceto, M. D. (1982). Nicotine-induced antinociception in rats and mice: Correlation with nicotine brain levels. J. Pharmacol. Exp. Ther. 221, 91-96.
39. 2+. Neuron 8, 353-362.
40. Vossler, M. R., Yao, H., York, R. D., Pan, M.-G., Rim, C. S., and Stork, P. J. S. (1997). cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89, 73-82.
41. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
42. Yamamoto, I., and Casida, J. E. (Eds.) (1999). Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor. Springer-Verlag, Tokyo.
43. Zwart, R., Abraham, D., Oortgiesen, M., and Vijverberg, H. P. M. (1994). α4β2 Subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells. Brain Res. 654, 312-318.