Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: Blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis

FASEB Journal

Volumn 14, Issue 13, 2000, Pages 1974-1978

  Egashira, Kensuke ^a   Koyanagi, Masamichi ^a   Kitamoto, Shiro ^a   Ni, Weihua ^a   Kataoka, Chu ^a   Morishita, Ryuichi ^b   Kaneda, Yasufumi ^b   Akiyama, Chiyuki ^c   Nishida, Ken Ichi ^c   Sueishi, Katsuo ^a   Takeshita, Akira ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Adhesion molecule; Endothelium derived relaxing factors; Gene transfer; Growth substances; Inflammation; Monocyte chemoattractant protein 1; Remodeling

Indexed keywords

MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTERIOSCLEROSIS; ARTERY INTIMA PROLIFERATION; ARTERY WALL; ARTICLE; CONTROLLED STUDY; CORONARY BLOOD VESSEL; DELETION MUTANT; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; LEUKOCYTE ADHERENCE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0033820635     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0141com     Document Type: Article

References (19)

1. Atherosclerosis - An inflammatory disease
2. Molecular bases of the acute coronary syndromes
3. Chemokines
4. Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody
5. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions
6. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
7. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
8. A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer
9. Hepatocyte growth factor gene therapy of liver cirrhosis in rats
10. Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats
11. Inhibition of nitric oxide synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels
12. Cardiac angiotensin II receptor is upregulated by long-term inhibition of nitric oxide synthesis in rats
13. Important role of local angiotensin II activity mediated via type 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats
14. Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultural human endothelial cells
15. Nitric oxide regulates monocyte chemotactic protein-1
16. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
17. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B
18. Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium
19. Intradermal injection of monocyte chemoattractant protein-1 induces emigration and differentiation of blood monocytes in rat skin