Immunomodulation: A new role for statins?

Nature Medicine

Volumn 6, Issue 12, 2000, Pages 1311-1312

  Palinski, W ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; STATIN; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTERY OCCLUSION; ATHEROSCLEROSIS; CHOLESTEROL METABOLISM; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; IMMUNE RESPONSE; IMMUNOMODULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SHORT SURVEY; STROKE; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ANTICHOLESTEREMIC AGENTS; ARTERIES; ARTERIOSCLEROSIS; CHOLESTEROL; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; HISTOCOMPATIBILITY ANTIGENS CLASS II; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES;

EID: 0034528569     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/82107     Document Type: Short Survey

References (12)

1. Current perspectives on statins
2. State-of-the-Art lecture. Statins and blockers of the renin-angiotensin system: Vascular protection beyond their primary mode of action
3. Statins (HMG-CoA Reductase Inhibitors) as a novel type of immunosuppressor
4. Effect of pravastatin on outcomes after cardiac transplantation
5. Simvastatin reduces graft vessel disease and mortality after heart transplantation: A four-year randomized trial
6. Regulation of MHC Class II genes: Lessons from a disease
7. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
8. 3-hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
9. Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s)
10. Specific immunotherapy: One size does not fit all
11. Immune responses to oxidative neoepitopes on LDL and phospholipids modulate the development of atherosclerosis
12. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions