Interplay between the molecular signals that control vertebrate limb development

International Journal of Developmental Biology

Volumn 46, Issue 7, 2002, Pages 877-881

  Niswander, Lee ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Anterior posterior; Dorsal ventral; FGF; Limb patterning; Proximal distal; SHH; WNT

Indexed keywords

ANTERIOR POSTERIOR AXIS; ARTICLE; EMBRYO; EMBRYO AXIS; EMBRYO PATTERN FORMATION; LIMB DEVELOPMENT; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; VERTEBRATE; ANIMAL; ECTODERM; LIMB; LIMB BUD; MESODERM; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; SIGNAL TRANSDUCTION;

VERTEBRATA;

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; ONCOPROTEIN; SONIC HEDGEHOG PROTEIN; TRANSACTIVATOR PROTEIN; WNT PROTEIN; ZEBRAFISH PROTEIN;

ANIMALS; BONE MORPHOGENETIC PROTEINS; ECTODERM; EXTREMITIES; FIBROBLAST GROWTH FACTORS; HEDGEHOG PROTEINS; LIMB BUD; MESODERM; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; VERTEBRATES; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 0036433866     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Ahn, K., Mishina, Y., Hanks, M. C., Behringer, R., and Crenshaw III, E. B. (2001). BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal/ventral patterning of the limb. Development 128:4449-4461.
2. Capdevila J., Tsukui, T., Rodriquez Esteban, C., Zappavigna, V., and Izpisua Belmonte, J. C. (1999). Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Molecular Cell 4: 839-849.
3. Caruccio, N. C., Martinez-Lopez, A., Harris, M., Dvorak, L., Bitgood, J., Simandl, B. K., and Fallon, J. F. (1999). Constitutive activation of Sonic Hedgehog signaling in the chicken mutant tapid2. Shh-independent outgrowth and polarizing activity. Develpmental Biology 212: 137-149.
4. Charité, J., Mcfadden, D. G., and Olson, E. N. (2000). The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development 127: 2461-2470.
5. Chen, H., Lun, Y., Ovchinnikov, D., Kokubo, H., Oberg, K. C., Pepicelli, C. V., Gan, L., Lee, B., and Johnson, R. L. (1998). Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nature Genetics 19: 51-55.
6. Chiang, C., Litingtung, Y., Harris, M. P., Simandl, B. K., Li, Y., Beachy, P. A., and Fallon, J. F. (2001). Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev. Bio. 236: 421-435.
7. Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., and Beachy, P. A. (1996). Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 383: 407-413.
8. Cygan, J. A., Johnson, R. L., and Mcmahon, A. P. (1997). Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development 124: 5021-5032.
9. Drossopoulou, G., Lewis, K. E., Sanz-Ezquerro, J. J., Nikbakht, N., Mcmahon, A. P., Hofmann, C., and Tickle, C. (2000). A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. Development 127: 1337-1348.
10. Eggenschwiler, J. T., Espinoza, E., and Anderson, K. V. (2001). Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 412: 194-198.
11. Fernandez-Teran, M., Piedra, M. E., Kathiriya, I. S., Srivastava, D., Rodriguez-Rey, J. C., and Ros, M, A. (2000). Role of dHAND in the anteriorposterior polarization of the limb bud: Implications for the Sonic hedgehog pathway. Development 127: 2133-2142.
12. Geduspan, J. S., and Maccabe, J. A. (1987). The ectodermal control of mesodermal patterns of differentiation in the developing chick wing. Dev. Biol. 124: 398-408.
13. Grieshammer, U., Minowada, G., Pisenti, J. M., Abbott, U. K., and Martin, G. R. (1996). The chick limbless mutation causes abnormalities in limb bud dorsalventral patterning: Implications for the mechanism of apical ridge formation. Development 122: 3851-3861.
14. Günther, T., Struwe, M., Aguzzi, A., and Schughart, K. (1994). Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development 120: 3119-3130.
15. Hui, C. C., and Joyner, A. L. (1993). A mouse model of grieg cephalopolysyndactyly syndrome: The extra-toes mutation contains an intragenic deletion of the Gli3 gene. Nature Genetics 3: 241-246.
16. Kawakami, Y., Capidevila, J., Büscher, D., Itoh, T., Rodriguez Esteban, C., and Izpisúa Belmonte, J. C. (2001). WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell 104: 891-900.
17. Kengaku, M., Capidevila, J., Rodriguez-Esteban, C., De La Peña, J., Johnson, R. L., Izpisúa Belmonte, J. C., and Tabin, C. J. (1998). Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280: 1274-1277.
18. Kraus, P., Fraidenraich, D., and Loomis, C. A. (2001). Some distal limb structures develop in mice lacking Sonic Hedgehog signaling. Mech. Dev. 100: 45-58.
19. Laufer, E., Nelson, C., Johnson, R. L., Morgan, B. A., and Tabin, C. (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79: 993-1003.
20. Lewandowski, M., Sun, X., and Martin, G. R. (2000). Fgf8 signaling from the AER is essential for normal limb development. Nature Genetics 26: 460-463.
21. Lewis, K. E., Drossopoulou, G., Paton, I. R., Morrice, D. R., Robertson, K. E., Burt, D. W., Ingham P.,W. and Tickle, C. (1999). Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway, Development 126: 2397-2407.
22. Logan, C., Hornbruch, A., Campbell, I., and Lumsden, A. (1997). The role of Engrailed in establishing the dorsoventral axis of the chick limb. Development 124: 2317-2324.
23. Loomis, C. A., Harris, E., Michaud, J., Wurst, W., Hanks, M., and Joyner, A. L. (1996). The mouse Engrailed-1 gene and ventral limb patterning. Nature 382: 360-363.
24. Loomis, C. A., Kimmel, R. A., Tong, C.-X., Michaud, J., and Joyner, A. L. (1998). Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs. Development 125:1137-1148.
25. Maccabe, J. A., Errick, J., and Saunders, J. W. (1974). Ectodermal control of the dorsoventral axis in the leg bud of the chick embryo. Dev. Biol. 39: 69-82.
26. Martin, G. R. (1998). The roles of FGFs in the early development of vertebrate limbs. Genes & Development 12: 1571-1586.
27. Masuya, H., Sagai, T., Wakana, S., Moriwaki, K., and Shiroishi, T. (1995). A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes & Development 9: 1645-1653.
28. Merino, R, Rodriguez-Leon, J., Macias, D., Ganan, Y., Economides, A.N. and Hurle, J.M. (1999), The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development 127: 5515-5522.]
29. Milenkovic, L., Goodrich, L. V., Higgins, K. M., and Scott, M. P. (1999). Mouse patched1 controls body size determination and limb patterning. Development 126: 4431-4440.
30. Min, H., Danilenko, D. M., Scully, S. A., Bolon, B., Ring, B. D., Tarpley, J. E., Derose, M., and Simonet, W. S. (1998), Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes & Development 12: 3156-3161.
31. Moon, A. M., and Capecchi, M. R. (2000), Fgf8 is required for outgrowth and patterning of the limbs. Nature Genetics 26: 455-469.
32. Niswander, L., Jeffrey, S., Martin, G. R., and Tickle, C. (1994). Positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371: 609-612.
33. Noramly, S., Pisenti, J., Abbott, U., and Morgan, B. (1996). Gene expression in the limbless mutant: Polarized gene expression in the absence of Shh and an AER. Dev. Biol. 179: 339-346.
34. Ohuchi, H., Nakagawa, T., Yamamoto, A., Araga, A., Ohata, T., Ishimaru, Y., Yoshioka, H., Kuwana, T., Nohno, T., Yamasaki, M., Itoh, N., and Noji, S. (1997). The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124: 2235-2244.
35. Parr, B. A., and Mcmahon, A. P. (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374: 350-353.
36. Pautou, M.-P. (1977). Dorso-ventral axis determination of chick limb bud development. in Vertebrate Limb and Somite Morphogenesis, D. A. Ede, J. R. Hinchliffe and M. Balls, eds.: Cambridge University Press), pp. 257-266.
37. Pizette, S., Abate-Shen, C., and Niswander, L. (2001). BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 128: 4463-4474.
38. Pizette, S., and Niswander, L. (1999). BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development 126: 883-894.
39. Porter, J. A., Young, K. E., and Beachy, P. A. (1996), Cholesterol modification of Hedgehog singalling proteins in animal development. Science 274: 255-259.
40. Qu, S., Niswender, K. D., Ji, Q., Van Der Meer, R., Keeney, D., Magnuson, M. A., and Wisdom, R. (1997), Poiydactyly and ecotpic ZPA formation in Alx-4 mutant mice. Development 124: 3999-4008.
41. Rancourt, D. E., Tsuzuki, T., and Capecchi, M. R. (1995). Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes & Development 9: 108-122.
42. Riddle, R. D., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. M., and Tabin, C. (1995). Induction of the LIM homebox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 83: 631-640.
43. Riddle, R. D., Johnson, R. L., Laufer, E., and Tabin, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75: 1401-1416.
44. Ros, M. A., Lopez-Martinez, A., Simandl, B. K., Rodriguez, C., Izpisua Belmonte, J. C., Dahn, R., and Fallon, J. F. (1996). The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions. Development 122: 2319-2330.
45. Sanz-Ezquerro, J. J., and Tickle, C. (2000). Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Development 127: 4811-4823.
46. Schimmang, T., Lemaistre, M., Vortkamp, A., and Ruther, U. (1992). Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt.). Development 116: 799-804.
47. Sekine, K., Ohuchi, H., Fujiwara, M., Yamasaki, M., Yoshizawa, T., Sato, T., Yagishita, N., Matsui, D., Koga, Y., Itoh, N., and Kato, S. (1999). Fgf10 is essential for limb and lung formation. Nature Genetics 21: 138-141.
48. Takahashi, M., Tamura, K., Buscher, D., Masuya, H., Yonei-Tamura, S., Matsumoto, K., Naitoh-Matsuo, M., Takeuchi, J., Ogura, K., Shiroishi, T., Ogura, T., and Izpisúa Belmonte, J. C. (1998). The role of AIx-4 in the establishment of anteroposterior polarity during vertebrate limb development. Development 125: 4417-4425.
49. Vogel, A., Rodriguez, C., Warnken, W., and Izpisúa -Belmonte, J. C. (1995). Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378: 716-720.
50. Yang, Y., and Niswander, L. (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning. Cell 80: 939-947.
51. Zúñiga, A., Haramis, A.-P., Mcmahon, A. P., and Zeller, R. (1999). Signal relay by BM P antagonism controls the SHH/FG F4 feedback loop in vertebrate limb buds. Nature 401: 598-602.
52. Zúñiga, A., and Zeller, R. (1999). Gli3 (Xt) and formin (Id) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development 126: 13-21.