The role of IL-5 in bleomycin-induced pulmonary fibrosis

Journal of Leukocyte Biology

Volumn 64, Issue 5, 1998, Pages 657-666

  Gharaee Kermani, Mehrnaz ^a   McGarry, Bridget ^a   Lukacs, Nicholas ^a   Huffnagle, Gary ^a   Egan, Robert W ^b   Phan, Sem H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cytokine expression; Eosinophils; Inflammation

Indexed keywords

BLEOMYCIN; CYTOKINE ANTIBODY; INTERLEUKIN 5;

ANIMAL TISSUE; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHILIA; FEMALE; LUNG FIBROSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALIA;

EID: 0031786332     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.64.5.657     Document Type: Article

References (68)

1. Durham, S. R., Kay, A. B. (1985) Eosinophils, bronchial hyperreactivity and late phase asthmatic reactions. Clin. Allergy 15, 411-418.
2. Gleich, G. J. (1990) The eosinophil and bronchial asthma: current understanding. J. Allergy Clin. Immunol. 85, 422-436.
3. Kay, A. B. (1991). Asthma and inflammation. J. Allergy Clin. Immunol. 87, 893-910.
4. Bousquet, J., Chanez, P., Lacoste, J. Y., Barneon, G., Ghavanian, N., Enandi, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J., Godard, P., Michel, F. B. (1990) Eosinophilic inflammation in asthma. N. Engl. J. Med. 323, 1033-1041.
5. Djukanovic, R., Wilson, J. W., Britten, K. M., Wilson, S. J., Walls, A. F., Roche, W., Howarth, P. H., Holgate, S. T. (1990) Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and health control subjects using immunohistochemistry. Am. Rev. Respir. Dis. 142, 863-871.
6. Minshall, E. M., Leung, D. Y. M., Martin, R. J., Song, Y. L., Cameron, L., Ernst, P., Hamid, Q. (1997) Eosinophil-associated TGFβ1 mRNA expression and airways fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 17, 326-333.
7. Spry, C. J. F., Kay A. B., Gleich G. J. (1992) Trend: eosinophils. Immunol. Today 12, 384-391.
8. Zhang, K., Gharaee-Kermani M., Jones M. L., Warren J. S., Phan S. H. (1994) Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J. Immunol. 153, 4733-4741.
9. Zhang, K., Flanders, K. C., Phan, S. H. (1995) Cellular localization of transforming growth factor-(expressioin in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 147, 352-361.
10. 1 by eosinophils during cutaneous wound healing in the hamster. Am. J. Pathol. 143, 130-140.
11. Wong, D. T. W., Weller, P. F., Galli, S. J., Elovic, H., Rand, T. H., Gallagher, G. T., Chiang, T., Chou, M. Y., Matossian, K., McBride, J., Todd, R. (1990) Human eosinophils express transforming growth factor α. J. Exp. Med. 172, 673-681.
12. Ohno, I., Lea, R., Finotto, S., Marshall, J., Denbury, J., Dolovich, J., Gauldie, J., Jordana, M. (1993) Granulocyte/macrophage colony-stimulating factor (GM-CSF) gene expression by eosinophils in nasal polyposis. Am. J. Respir. Cell. Mol. Biol. 5, 505-512.
13. White, D. A., Kris, M. G., Stover, D. E. (1987) Bronchoalveolar lavage cell populations in bleomycin lung toxicity. Thorax 42, 551-552.
14. Noguchi, H., Kephart, G. M., Colby, T. V., Gleich, G. J. (1992) Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis. Am. J. Pathol. 140, 521-528.
15. Gharaee-Kermani, M., Phan, S. H. (1998) The role of eosinophils in pulmonary fibrosis. Int. J. Mol. Med. 1, 42-53.
16. Gharaee-Kermani, M., Phan, S. H. (1997) Lung interleukin-5 expression in murine bleomycin-induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 16, 438-447.
17. Gulbenkina, A. R., Egan, R. W., Fernandez, X., Jones, H., Kreutner, W., Kung, T., Payvandi, F., Sullivan, L., Zurcher, J. A., Watnick, A. S. (1992) Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung. Am. Rev. Respir. Dis. 146, 263-265.
18. Peterson, M. W., Monick, M., Hunninghake, G. W. (1987) Prognostic role of eosinophils in pulmonary fibrosis. Chest 92, 51-56.
19. Hallgren, R., Bjermer, L., Lundgren. R., Venge, P. (1989) The eosinophil component of the alveolitis in idiopathic pulmonary fibrosis: signs of eosinophil activation in the lung are related to impaired lung function. Am. Rev. Respir. Dis. 139, 373-377.
20. Kung, T. T., Stelts, D. M., Zurcher, J. A., Adams, G. K., III, Egan, R. W., Kreutner, W., Watnick, A. S., Jones, H., Chapman, R. W. (1995) Involvement of IL-5 in a murine model of allergic pulmonary inflammation: Prophylactic and therapeutic effect of an anti-IL-5 antibody. Am. J. Respir. Cell Mol. Biol. 13, 360-365.
21. Yamaguchi, Y., Hayashi, Y., Sugama, Y., Miura, Y., Kasahana, T., Kitamura, S., Torisu, M., Mita, S., Tominaga, A., Takatsu, K., Suda, T. (1988) Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. J. Exp. Med. 167, 1737-1742.
22. Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthaei, K. I., Young, I. G. (1996) Interleukin-5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183, 195-201.
23. Nagai, H., Yamaguchi, S., Inagaki, N., Tsurouka, N., Hitoshi, Y., Takatsu, K. (1993) Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice. Life Sci. 53, 243-247.
24. Chand, N., Harrison, J. E., Rooney, S., Pillar, J., Jakubicki, R., Nolan, K., Diamantis, W., Sofia, R. D. (1992) Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: A therapeutic approach. Eur. J. Pharmacol. 211, 121-123.
25. Mauser, P. J., Pitman, A., Fernandez, X., Zurcher, J. A., Kung, T. T., Watnick, A. S., Egan, R. W., Kreutner, W., Adams, G. K., III (1993) Inhibitory effect of TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am. Rev. Respir. Dis. 148, 1623-1627.
26. Van Oosterhout, A. J. M., Ladenius, A. R. C., Savelkoul, H. F. J., Van Ark, I., Delsman, K. C., Nijkamp, F. P. (1993) Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs. Am. Rev. Respir. Dis. 147, 548-552.
27. Mauser, P. F., Pitman, A. M., Fernandez, X., Foran, S. K., Adams, G. K., III, Kreutner, W., Egan, R. W., Chapman, R. W. (1995) Effects of an antibody to IL-5 in a monkey model of asthma. Am. J. Respir. Crit. Care Med. 152, 467-172.
28. + T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am. Rev. Respir. Dis. 146, 374-377.
29. Fukuda, T., Fukushima, Y., Numao, T., Ando, N., Arima, M., Nakajima, H., Sagara, H., Adachi, T., Motojima, S., Makino, S. (1996) Role of interleukin-4 and vascular cell adhesion molecule-1 in selective eosinophil migration into the airways in allergic asthma. Am. J. Respir. Cell Mol. Biol. 14, 84-94.
30. Rot, A., Krieger, M., Brunner, T., Bischoff, S. C., Schall, T. J., Dahinden, C. A. (1992) RANTES and macrophage inflammatory-protein 1α induce the migration and activation of normal human eosinophil granulocytes. J. Exp. Med. 176, 1489-1495.
31. Collins, P. D., Marleau, S., Griffiths-Johnson, D. A., Jose, P. J., Williams, T. J. (1995) Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J. Exp. Med. 182, 1169-1174.
32. Schumacher, J.H., O'Garra, J. H., Shrader, B., van Kimmenade, A., Bond, M. W., Mosmann, T R., Coffman, R. L. (1988) The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent assays. J. Immunol. 141, 1576-1581.
33. Coffman, R. L., Seymour, B. W. P., Hudak, S., Jackson, J., Rennick, D. (1989) Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science 245, 308-310.
34. Gharaee-Kermani, M., Denholm, E. M., Phan, S. H. (1996) Co-stimulation of fibroblast collagen and transforming growth factor β1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J. Biol. Chem. 271, 17779-17784.
35. Phan, S. H., Gharaee-Kermani, M., Wolber, F., Ryan, U. S. (1991) Stimulation of rat endothelial cell transforming growth factor-β production by bleomycin. J. Clin. Invest. 87, 148-154.
36. Zhang, K., Gharaee-Kermani, M., McGarry, B., Phan, S. H. (1994) In situ hybridization analysis of rat lung a1(1) and a2(1) collagen gene expression in pulmonary fibrosis induced by endotracheal bleomycin injection. Lab. Invest. 70, 192-202.
37. Phan, S. H., Kunkel, S. L. (1992) Lung cytokine production in bleomycin-induced pulmonary fibrosis in mice. Exp. Lung Res. 18, 29-43.
38. Phan, S. H., Gharaee-Kermani, M., McGarry, B., Kunkel, S. L., Wolber, F. W. (1992) Regulation of rat pulmonary artery endothelial cell transforming growth factor-β production of IL-1β and tumor necrosis factor-α. J. Immunol. 149, 103-106.
39. Derynck, R., Jarrett, J. H., Chen, Y., Goeddel, D. V. (1986) The murine transforming growth factor beta precursor. J. Biol. Chem. 261, 4377-4379.
40. Rollins, B. J., Morrison, E. D., Stiles, C. D. (1988) Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc. Natl. Acad Sci. USA 85, 3738-3742.
41. Sabath, D. E., Brome H. E., Prystowsky, M. B. (1990) Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin-1 induced transcript in a cloned T-helper lymphocyte. Gene 91, 185-191.
42. Phan, S. H., Kunkel, S. L. (1986) Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguiaretic acid: the role of alveolar macrophages activation and mediator production. Am. J. Pathol. 124, 343-351.
43. Lukacs, N. W., Stricter, R. M., Warmington, K., Lincoln, P., Chensue, S. W., Kunkel, S. L., (1997) Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation. J. Immunol. 158, 4398-4404.
44. Mason, D. Y., Sammons, R. (1978) Alkaline phosphatase and peroxidase for double immunizing labeling of cellular contacts. J. Clin. Pathol. 31, 454-460.
45. Zhang, K., Rekhter, M. D., Gordon, D., Phan, S. H. (1994) Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis: A combined immunohistochemical and in situ hybridization study. Am. J. Pathol. 145, 114-125.
46. Campana, D., Thompson, J. S., Almot, P., Brown, S., Janossy, G. (1987) The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T-lymphoid lineage. J. Immunol. 138, 648-655.
47. Dent, L. A., Strath, M., Mellor, A. L., Sanderson, C. J. (1990) Eosinophilia in transgenic mice expression interleukin-5. J. Exp. Med. 172, 1425-1431.
48. Lukacs, N. W., Strieter, R. M., Chensue, S. W., Kunkel, S. L. (1994) Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma. Am. J. Respir. Cell Mol. Biol. 10, 526-532.
49. Lukacs, N. W., Stricter, R. M., Chensue, S. W., Widmer, M., Kunkel, S. L. (1993) TNF α mediates recruitment of neutrophils and eosinophils during allergic airway inflammation. J. Immunol. 154, 5411-5417.
50. Gharaee-Kermani, M., Wiggins, R., Wolber, F., Goyal, M., Phan, S. H. (1996) Fibronectin is the major fibroblast chemoattractant in anti-GBM disease. Am. J. Pathol. 148, 961-967.
51. Coffman, R. L., Seymour, B., Lehman, D. A., Hiraki, D. D., Christiansen, J. A., Shrader, B., Cherwinski, H. M., Savelhoul, H. F. J., Kinkelman, F. D., Bond, N. W., Mosmann, T. R. (1988) The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102, 5-28.
52. Garlisi, C. G., Falcone, A., Kung, T. T., Stalts, D., Pennline, K. J., Beavis, A. J., Smith, S. R., Egan, R. W., Umland, S. P. (1995) T cells are necessary for Th2 cytokine production and eosinophil accumulatioin in airways of antigen-challenged allergic mice. Clin. Immunol. Immunopathol. 75, 75-83.
53. Kung, T. T., Stelts, D., Zurcher, J., Jones, H., Umland, S. P., Kreutner, W., Egan, R. W., Chapman, R. W. (1995) Mast cells modulate allergic pulmonary eosinophilia in mice. Am. J. Respir. Cell Mol. Biol. 12, 404-409.
54. Robinson, D. S., Hamid, Q., Ying, S., Tsicopulos, A., Barkans, J., Bentey, A. M., Corrigan, C., Durham, S. R., Kay, A. B. (1992) Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326, 298-304.
55. Walsh, G. M., Hartnell, A., Wardlaw, A. J., Kurihara, K., Sanderson, C. J., Kay, A. B. (1990) IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunol. 71, 258-265.
56. Lopez, A. F., Sanderson, C. J., Gamble, J. R., Campbell, H. R., Young, I. G., Vadas, M. A. (1988) Recombinant human interleukin-5 is a selective activator of human eosinophil function. J. Exp. Med. 167, 219-224.
57. Wang, J. M., Rambaldi, A., Biondi, A., Chen, Z. G., Sanderson, C. J., Mantovani, A. (1989) Recombinant human interleukin-5 is a selective eosinophil chemoattractant. Eur. J. Immunol. 19, 701-705.
58. Resnick, M. B., Weller, P. F. (1993) Mechanisms of eosinophil recruitment. Am. J. Respir. Cell Mol. Biol. 8, 349-355.
59. Yamaguchi, Y., Suda, T., Shiozaki, H., Miura, Y., Hitoshi, Y., Tommaga, A., Takatsu, K., Kasahara, T. (1990) Role of IL-5 in IL-2 induced eosinophilia. In vivo and in vitro expression of IL-5 mRNA by IL-2. J. Immunol. 145, 873-877.
60. Egan, R. W., Athwahl, D., Chou, C., Emtage, S., Jehn, C., Kung, T. T., Mauser, P. J., Murgolo, N., Bodmer, M. (1995) Inhibition of pulmonary esoinophilia and hyperreactivity by antibodies to interleukin-5. Int. Arch. Allergy Immunol. 107, 321-322.
61. Ohnishi, T., Sur, S., Collin, D. S., Fish, J. E., Gleich, G. J., Peters, S. P. (1993) Eosinophil survival activity identified as interlukin-5 is associated with eosinophil recruitment and degranulation and lung injury twenty four hours after segmental antigen lung challenge. J. Allergy Clin. Immunol. 92, 607-615.
62. Weller, P. F. (1991) The immunology of eosinophils. N. Engl J. Med. 324, 1110-1118.
63. Zhang, K., Gharaee-Kermani, M., McGarry, B., Remick, D., Phan, S. H. (1997) TNFα mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis. J. Immunol. 158, 954-959.
64. Janick-Buckner, D., Ranges, G. E., Hacker, M. P. (1989) Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice. Toxicol. Appl. Pharmacol. 100, 474-84.
65. Ying, S., Robinson, D. S., Varney, V., Meng, Q., Tsicopoulos, A., Moqbel, R., Durham, S. R., Kay, A. B., Hamid, Q. (1991) TNF alpha mRNA expression in allergic inflammation. Clin. Exp. Allergy 21, 745-750.
66. Desreumaux, P., Janin, A., Colombel, J. F., Prin, L., Plumas, J., Emilie, D., Torpier, G., Capron. A., Capron, M. (1992) Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease. J. Exp. Med. 175, 293-296.
67. Silberstein, D. S., Owen, W. F., Gasson, J. C., DiPersio, J. F., Golde, D. W., Bina, J. C. (1986) Eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor. J. Immunol. 137, 3290-3292.
68. Silberstein, D. S., David J. R. (1987) The regulation of human eosinophil function by cytokines. Immunol. Today 8, 380-385.