Compensatory renal hypertrophy is mediated by a cell cycle-dependent mechanism

Kidney International

Volumn 62, Issue 5, 2002, Pages 1650-1658

  Liu, Baolian ^a   Preisig, Patricia A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

G1 cell cycle kinases; Kidney size; Proximal tubule; Renal mass; Roscovitine; Uninephrectomy

Indexed keywords

BROXURIDINE; CYCLIN D; CYCLIN E KINASE; DNA; ENZYME INHIBITOR; PHOSPHOTRANSFERASE; PROTEIN; ROSCOVITINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE MARKER; DNA DETERMINATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; HYPERPLASIA; HYPERTROPHY; IN VITRO STUDY; KIDNEY CORTEX; KIDNEY DEVELOPMENT; KIDNEY HYPERTROPHY; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; MOUSE STRAIN; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; RAT; SURGICAL TECHNIQUE; UNINEPHRECTOMY;

EID: 0036408407     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00620.x     Document Type: Article

References (28)

1. Franch HA, Shay JW, Alpern RJ, Preisig PA: Involvement of pRB family in TGFβ-dependent epithelial cell hypertrophy. J Cell Biol 129:245-254, 1995
2. 4Cl-induced hypertrophy is mediated by weak base effects and is independent of cell cycle processes. Am J Physiol 270:C932-C938, 1996
3. Preisig PA, Franch HA: Renal epithelial cell hyperplasia and hypertrophy. Semin Nephrol 15:327-340, 1995
4. Preisig PA: Renal hypertrophy and hyperplasia (chapt 27), in The Kidney: Physiology and Pathophysiology (vol 1, 3rd Ed), edited by Selden DW, Giebisch G, Philadelphia, Lippincott Williams & Wilkins, 2000, pp 727-748
5. Liu B, Preisig PA: TGFβ-mediated hypertrophy in rat renal epithelial cells involves inhibiting pRB phosphorylation by preventing activation of cdk2/cyclin E kinase. Am J Physiol 277:F186F194, 1999
6. Preisig PA: What makes cells grow larger and how do they do it: Hypertrophy revisited. Exper Nephrol 7:273-283, 1999
7. 1 kinases and transforming growth factor-β signaling are associated with a growth pattern switch in diabetes-induced renal growth. Kidney Int 58:162-172, 2000
8. 1 cells. Kidney Int 42:595-601, 1992
9. 4C1 in cultured renal proximal tubule cells. J Am Soc Nephrol 7:73-80, 1996
10. 3 symporter activties in chronic hyperfiltration: A model of cell hypertrophy. J Gen Physiol 97:195-217, 1991
11. De Azevedo WE, Leclerc S, Meijer L, et al: Inhibition of cyclindependent kinases by purine analogues: Crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem 243:518-526,1997
12. Meijer L, Borgne A, Mulner O, et al: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclindependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 243:527536, 1997
13. Pippin J, Qu Q, Mieijer L, Shankland SJ: Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with roscovitine, a novel cyclin-dependent kinase antagonist. J Clin Invest 100:2512-2520, 1997
14. 23Na NMR spectroscopy of proximal tubule suspensions. Kidney Int 29:747-751, 1986
15. Schaefer L, Schaefer RM, Teschner M, Heidland A: Renal proteinases and kidney hypertrophy in experimental diabetes. Diabetologia 37:567-571, 1994
16. Piatti S: Cell cycle regulation of S phase entry in Saccharomyces cerevisiae. Prog Cell Cycle Res 3:143-156, 1997
17. Zetterberg A, Larsson O, Wiman KG: What is the restriction point? Curr Biol 7:835-842, 1995
18. Kitagawa M, Higashi H, Jung H-K, et al: The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 15:7060-7069,1997
19. Lundberg AS, Weinberg RA: Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 18:753-761, 1998
20. Weintraub SJ, Prater CA, Dean DC: Retinoblastoma protein switches the E2F site from a positive to negative element. Nature 358:259-261, 1992
21. Shankland SJ, Wolf G: Cell cycle regulatory proteins in renal disease: Role in hypertrophy, proliferation, and apoptosis. Am J Physiol 278:F515-F529, 2000
22. Kip1 in diabetic db/db mouse: Role of hyperglycemia. Kidney Intern 53:869-879, 1998
23. Wolf G, Schroeder R, Ziyadeh FN, et al: High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: Relationship to hypertrophy. Am J Physiol 273:F348-F356, 1997
24. WAF1, CIP1 is increased in experimental diabetic nephropathy: Potential role in glomerular hypertrophy. J Am Soc Nephrol 9:986993, 1998
25. Wolf G, Schroeder R, Zahner G, et al: High glucose-induced hypertrophy of mesangial cells requires p27 (Kip1), an inhibitor of cyclin-dependent kinases. Am J Pathol 158:1091-1100, 2001
26. Kip1. Kidney Int 50:2112-2119, 1996
27. Kip1 expression in diabetic BBdp rats. Diabetologia 42:14251432, 1999
28. WAF/CIP1 is required for glomerular hypertrophy in experimental diabetic nephropathy. Kidney Int 56:1691-1699, 1999