Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1

Diabetic Medicine

Volumn 19, Issue 10, 2002, Pages 804-809

  Berger, D ^a   Barroso, I ^b   Soos, M ^a   Yeo, G ^a   Schafer, A J ^b   O'Rahilly, S ^a   Whitehead, J P ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Incyte Genomics Ltd ^*  (United Kingdom)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Insulin receptor substrate 1; Insulin resistance; Syndromes; Variants

Indexed keywords

ALANINE; GLUTAMINE; GLYCINE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHOTRANSFERASE; PROLINE; PROTEIN P85;

AMINO ACID SUBSTITUTION; ANALYSIS; ARTICLE; CONTROLLED STUDY; DNA VECTOR; ENZYME ACTIVITY; FLUORESCENCE; GENE; GENE MUTATION; GENETIC ANALYSIS; GENETIC TRANSFECTION; GENETIC VARIABILITY; HAMSTER; HETEROZYGOSITY; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; OVARY; PHOSPHORYLATION; PROTEIN VARIANT; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SYNDROME; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CASE-CONTROL STUDIES; CHO CELLS; CRICETINAE; DNA MUTATIONAL ANALYSIS; HUMANS; METABOLIC SYNDROME X; PHOSPHOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0036400206     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-5491.2002.00779.x     Document Type: Article

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