Ketoconazole suppresses interleukin-4 plus anti-CD40-induced IgE class switching in surface IGE negative B cells from patients with atopic dermatitis

Journal of Investigative Dermatology

Volumn 119, Issue 3, 2002, Pages 590-599

  Kanda, Naoko ^a   Watanabe, Shinichi ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

C; cAMP; EBP; Nuclear factor B

Indexed keywords

ADENYLATE CYCLASE; ANTIBODY; BINDING PROTEIN; CD40 ANTIBODY; CYCLIC AMP; CYCLIC AMP DERIVATIVE; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; KETOCONAZOLE; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ALLERGIC DISEASE; ARTICLE; ATOPIC DERMATITIS; B LYMPHOCYTE; BLOOD DONOR; BURKITT LYMPHOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENHANCER REGION; FEMALE; GENE REARRANGEMENT; GERM LINE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; INHIBITION KINETICS; LYMPHOMA CELL; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROPHYLAXIS; SIGNAL TRANSDUCTION;

EID: 0036379411     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01864.x     Document Type: Article

References (73)

1. Agut J, Palacin C, Salgado J, Casas E, Sacristan A, Ortiz JA: Direct membrane-damaging effect of sertaconazole on Candida albicans as a mechanism of its fungicidal activity. Arzneimittelforschung 42:721-724, 1992
2. Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C: A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-Fos. Mol Cell Biol 18:967-977, 1998
3. Albrecht B, Peiritsch S, Woisetschlager M: A bifunctional control element in the human IgE germline promoter involved in repression and IL-4 activation. Int Immunol 6:1143-1151, 1994
4. Back O, Scheynius A, Hohansson SG: Ketoconazole in atopic dermatitis: therapeutic response is correlated with decrease in serum IgE. Arch Dermatol Res 287:448- 451, 1995
5. Baroni A, Ruocco V, de Paolis P, Cicatiello L, Esumi H, Tufano MA: Ketoconazole inhibits lipopolysaccharide-induced activation of the nitric oxide synthase gene in the murine macrophage cell line J774. Arch Dermatol Res 291:54-58, 1999
6. Bell JD, Buxton IL, Brunton LL: Enhancement of adenylate cyclase activity in S49 lymphoma cells by phobol esters. J Biol Chem 260:2625-2628, 1985
7. Berberich I, Shu GL, Clark EA: Cross-linking CD40 on B cells rapidly activates nuclear factor-κB. J Immunol 153:4357-4366, 1994
8. Berberich I, Shu G, Siebelt F, Woodgett JR, Kyriakis JN, Clark EA: Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases. EMBO J 15:92-101, 1996
9. Berrier A, Siu G, Calame K: Transcription of a minimal promoter from the NF-IL-6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells. J Immunol 161:2267-2275, 1998
10. Bettens JR, Loots W, Somers Y, Coene MC, de Clerck F: Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo. Biochem Pharmacol 35:883-891, 1986
11. Bihoreau C, Heurtier A, Enjalbert A, Corvaia N, Bensussan A, Degos L, Kordon C: Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways. Eur J Immunol 21:2877-2882, 1991
12. Bomsztyk K, Toivola B, Emery DW, Rooney JW, Dower SK, Rachie NA, Sibley CH: Role of cAMP in interleukin-1-induced κ light chain gene expression in murine B cell line. J Biol Chem 265:9413-9417, 1990
13. Boyum A: Separation of leukocytes from peripheral blood and bone marrow. Scand J Clin Laboratory Invest 21 (Suppl. 97):77-89, 1968
14. Broberg A, Faergemann J: Topical antimycotic treatment of atopic dermatitis in the head/neck area. A double-blind randomized study. Acta Derm Venereol (Stockh) 75:46-49, 1995
15. Casilas AM, Thompson AD, Cheshier S, Hernandez S, Aguilera RJ: RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines. Mol Immunol 32:167-175, 1995
16. i-α and specific suppression of type 2 adenylyl cyclase inhibition by phorbol ester treatment. J Biol Chem 268:12253-12256, 1993
17. Chinery R, Brockman JA, Dransfield DT, Coffey RJ: Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein b. J Biol Chem 272:30356- 30361, 1997
18. Choi EJ, Xia Z, Storm DR: Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin. Biochemistry 31:6492-6498, 1992
19. Clemmensen OJ, Hjorth N: Treatment of dermatitis of the head and neck with ketoconazole in patients with type I sensitivity to Pityrosporum orbiculare. Semin Dermatol 2:26-29, 1983
20. Coqueret O, Boichot E, Lagente V: Selective type IV phosphodiesterase inhibitors prevent IL-4-induced IgE production by human peripheral blood mononuclear cells. Clin Exp Allergy 27:816-823, 1997
21. Delphin S, Stavnezer J: Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline e promoter: regulation by NF-IL-4, a C/EBP family member and NF-κB/p50. J Exp Med 181:181-192, 1995
22. Elewski BE: Mechanisms of action of systemic antifungal agents. J Am Acad Dermatol 28:S28-S34, 1993
23. Farrant J, Bryant AE, Lever AML, Edwards AJ, Knight SC, Webster ADB: Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia: Low immunoglobulin production on stimulation of normal B cells. Clin Exp Immunol 61:189-194, 1985
24. Fawcett TW, Martindale JL, Guyton KZ, Hai T, Holbrook NJ: Complexes containing activating transcription factor (ATF)/cAMP-responsive element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. Biochem J 339:135-141, 1999
25. Finney M, Guy GR, Michell RH, Gordon J, Dugas B, Rigley KP, Callard RE: Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation. Eur J Immunol 20:151-156, 1990
26. Gauchat J-F, Lebman DA, Coffman RL, Gascan H, de Vries JE: Structure and expression of germline transcripts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 172:463-473, 1990
27. Gee AP, Lee C, Sleasman JW, Madden M, Ugelstad J, Barret DJ: T lymphocyte depletion of human peripheral blood and bone marrow using monoclonal antibodies and magnetic microspheres. Bone Marrow Transplant 2:155-163, 1987
28. Gonzalez GA, Montminy MR: Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675-680, 1989
29. Grewe M, Bruijnzeel-Koomen CAFM, Schopf E, Thepen T, Langeveld-Wildschut AG, Ruzicka T, Krutmann J: A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today 19:359-361, 1998
30. Hanifin JM, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) Suppl 92:44-47, 1980
31. Ichiki T, Takahashi W, Watanabe T: Regulation of the expression of human Cε germline transcript. J Immunol 150:5408-5417, 1993
32. Iciek LA, Delphin SA, Stavnezer J: CD40 cross-linking induces Ige germline transcripts in B cells via activation of NF-κB. Synergy with IL-4 induction. J Immunol 158:4769-4779, 1997
33. Ikizawa K, Kajiwara K, Koshio T, Yanagihara Y: Possible role of tyrpsine kinase activity in interleukin 5-induced expression of gemline Cε transcripts in a human Burkitt lymphoma B-cell line, DND39. J Allergy Clin Immunol 94:620-624, 1994
34. Ikizawa K, Yanagihara Y: Possible involvement of Shc in IL-4-induced germline ε transcription in a human B cell line. Biochem Biophys Res Commun 268:54-59, 2000
35. Iyengar R: Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases. FASEB J 7:768-775, 1993
36. Jabara HH, Schnider LC, Shapira SK, et al: Induction of germ-line and mature Cε transcripts in human B cells stimulated with rIL-4 and EBV. J Immunol 145:3468-3473, 1990
37. Jacobowitz O, Iyengar R: Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc Natl Acad Sci USA 91:10630-10634, 1994
38. Kanda N, Enomoto U, Watanabe S: Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis. J Invest Dermatol 117:1635-1646, 2001
39. Kato T, Kokuho T, Tamura T, Nariuchi H: Mechanisms of T cell contact-dependent B cell activation. J Immunol 152:2130-2138, 1994
40. Knox KA, Johnson GD, Gordon J: Distribution of cAMP in secondary follicles and its expression in B cell apoptosis and CD40-mediated survival. Int Immuol 5:1085-1091, 1993
41. Lapointe R, Lemieux R, Olivier M, Darveau A: Tyrosine kinase and cAMP-dependent protein kinase activities in CD40-activated human B lymphocytes. Eur J Immunol 26:2376-2382, 1996
42. Leung DYM: Atopic dermatitis: the skin as a window into the pathogenesis of chronic allergic diseases. J Allergy Clin Immunol 96:302-318, 1995
43. Mckay CE, Hewitt EL, Ozanne BW, Cushley W: A functional role for interleukin (IL)-4-driven cyclic AMP accumulation in human B lymphocytes. Cytokine 12:731-736, 2000
44. Menetski JP, Gellert M: V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP. Proc Natl Acad Sci USA 87:9324-9328, 1990
45. Metz R, Ziff E: cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to translocate to the nucleus and induce c-fos transcription. Genes Dev 5:1754-1766, 1991
46. Mikita T, Kurama M, Schindler U: Synergistic activation of the germline e promoter mediated by Stat6 and C/EBP. J Immunol 161:1822-1828, 1998
47. Monticelli S, Vercelli D: Molecular regulation of class switch recombination to IgE through e germline transcription. Allergy 56:270-278, 2001
48. Motomura T, Kawayama S, Takagi M, et al: Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein. J Bone Miner Res 13:1084-1091, 1998
49. Niehof M, Kubicka S, Zender L, Manns MP, Trautwein C: Autoregulation enables different pathways to control CCAAT/enhancer binding protein β (C/EBPβ) transcription. J Mol Biol 309:855-868, 2001
50. Park EA, Song S, Vinson C, Roesler WJ: Role of CCAAT/enhancer-binding protein β in the thyroid hormone and cAMP induction of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem 274:211-217, 1999
51. Pesu M, Takaluoma K, Aittomaki S, Lagerstedt A, Saksela K, Koaven PE, Silvennoinen O: Interleukin-4-induced transcriptional activation by Stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of Stat6. Blood 95:494-502, 2000
52. Pohnke Y, Kempf R, Gellersen B: CCAAT/enhancer-binding proteins are mediators in the protein kinase A-dependent activation of the decidual prolactin promoter. J Biol Chem 274:24808-24818, 1999
53. Punt CJA, Barbuto JAM, Zhang H, Grimes WJ, Hatch KD, Hersh EM: Anti-tumor antibody produced by human tumor-infiltrating and peripheral blood B lymphocytes. Cancer Immunol Immunother 38:225-232, 1994
54. Ren CL, Morio T, Fu SM, Geha RS: Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J Exp Med 179:673-680, 1994
55. Robicsek SA, Blanchard DK, Djeu JY, Krzanowski JJ, Szentivany A, Polson JB: Multiple high-affinity cAMP-phosphodiesterase in human T-lymphocytes. Biochem Pharmacol 42:869-877, 1991
56. Salomon Y, Londons D, Rodbell M: A highly sensitive adenylate cyclase assay. Anal Biochem 58:541-548, 1974
57. Shapira SK, Vercelli D, Jabara HH, Fu SN, Geha RS: Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen. J Exp Med 175:289-292, 1992
58. Shen C-H, Stavnezer J: Activation of the mouse Ig germline ε promoter by IL-4 is dependent on AP-1 transcription factors. J Immunol 166:411-423, 2001
59. Shirakawa F, Mizel SB: In vitro activation and nuclear translocation of NF-κB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol 9:2424-2430, 1989
60. Shirakawa F, Chedid M, Suttles J, Pollok BA, Mizel SB: Interleukin 1 and cyclic AMP induce κ immunoglobulin light-chain expression via activation of an NF-κB like DNA-binding protein. Mol Cell Biol 9:959-964, 1989
61. Sozzani P, Cambon C, Vita N, Sequelas M-H, Caput D, Ferrara P, Pipy B: Interlukin-13 inhibits protein kinase C-triggered respiratory burst in human monocytes. Role of calcium and cyclic AMP. J Biol Chem 270:5084-5088, 1995
62. Stalla GK, Stalla J, Huber M, Loeffler JP, Hollt V, von Werder K, Muller OA: Ketoconazole inhibits corticotropic cell function in vitro. Endocrinology 122:618-623, 1988
63. Stalla GK, Stalla J, von Werder K, Muller OA, Gerzer R, Hollt V, Jakobs KH: Nitroimidazole derivatives iinhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme. Endocrinology 125:699-706, 1989
64. Stevens S, Wang L, Roeder RG: Functional analysis of the OCA-B promoter. J Immunol 164:6372-6379, 2000
65. Stutz AM, Woistetschlager M: Functional synergism of STAT6 with either NF-κB or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol 163:4383-4391, 1999
66. Tengvall Linder M, Johansson C, Zargari A, et al: Detection of Pityrosporum orbiculare reactive T cells from skin and blood in atopic dermatitis and characterization of their cytokine profiles. Clin Exp Allergy 26:1286-1297, 1996
67. Thienes CP, de Monte L, Monticelli S, Busslinger M, Gould HJ, Vercelli D: The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human germline promoter. J Immunol 158:5874-5882, 1997
68. Watson PA, Krupinski J, Kempinski AM, Frankenfield CD: Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. J Biol Chem 269:28893-28898, 1994
69. Werfel S, Massey W, Lichtenstein LM, Bochner BS: Preferential recruitment of activated, memory T lymphocytes into skin chamber fluids during human cutaneous late-phase allergic reactions. J Allergy Clin Immunol 96:57-65, 1995
70. Wierenga EA, Snoek M, Jansen HM, Bos JD, van Lier RA, Kapsenberg ML: Human atopen-specific types 1 and 2 helper cell clones. J Immunol 147:2942-2949, 1991
71. Worm M, Henz BM: Molecular regulation of human IgE synthesis. J Mol Med 75:440-447, 1997
72. Yanagihara Y, Basaki Y, Ikizawa K, Kajiwara K, Koshio T, Akiyama K: Involvement of nuclear factor-B activation in IgE synthesis in human B cells. J Allergy Clin Immunol 98:S224-S229, 1996
73. Zhou J, Finch PW: Identification of a novel transcriptional regulatory element within the promoter region of the keratinocyte growth factor gene that mediates inducibility to cyclic AMP. Biochim Biophys Acta 1446:71-81, 1999