Molecular regulation of human IgE synthesis

Journal of Molecular Medicine

Volumn 75, Issue 6, 1997, Pages 440-447

  Worm, Margitta ^a,b   Henz, Beate M ^b,c  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

B cells; CD40; CD40L; IgE synthesis; Interleukin 4

Indexed keywords

CD40 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR;

ATOPIC DERMATITIS; B LYMPHOCYTE; BASOPHIL; CELL CONTACT; IMMUNOGLOBULIN PRODUCTION; MAST CELL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIGENS, CD40; CD40 LIGAND; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-4; LIGANDS; MEMBRANE GLYCOPROTEINS; PLASMA CELLS;

EID: 0030742592     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050129     Document Type: Review

References (68)

1. Abbas AK, Lichtman AH, Pober JS (1994) Cellular and molecular immunology. Saunders, Philadelphia, pp 187-204
2. Vitetta ES, Fernandez-Botran R, Meyers CD, Sanders VM (1989) Cellular interactions in the humoral immune response. Adv Immunol 45:1-105
3. Lanzavecchia A (1990) Receptor mediated antigen uptake and its effect on antigen presentation to class II MHC-restricted T lymphocytes. Ann Rev Immunol 8:773-793
4. Jelinek DF, Lipsky PE (1987) Regulation of human B lymphocyte activation, proliferation and differentiation. Adv Immunol 40:1-6
5. Vercelli D, Geha RS (1992) Regulation of isotype switching. Curr Opin Immunol 4:794-797
6. Oettinger MA, Schatz DG, Gorka C (1990) RAG-1 and RAG-2 adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523.
7. Schatz DG, Oettinger MA, Schissel MS (1992) V(D)J recombination: molecular biology and regulation. Ann Rev Immunol 10:359-383
8. Severinson E, Fernandez C, Stavnezer J (1990) Induction of germline immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination. Eur J Immunol 20:1079-1084
9. Jung S, Rajewski A, Radbruch A (1993) Shut down of class switch recombination by deletion of a switch region control element. Science 259:984-987
10. Bottaro A, Lansford R, Xu L, Zhang J, Rothman P, Alt FW (1994) S region transcription per se promotes basal IgE class switching recombination but additional factors regulate the efficiancy of the process. EMBO J 13:665-674
11. Punnonen J, Aversa G, Cocks BG et al (1993) Interleukin-13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90:3730-3734
12. Pene J, Rousset F, Briere F et al (1988) IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons γ and α and prostaglandin E2. Proc Natl Acad Sci USA 85:6880-6884
13. Coffman RL, Ohara J, Bond MW, Carty J, Zlotnick A, Paul WE (1986) B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide activated B cells. J Immunol 136: 4538-4545
14. Urban J, Katona IM, Paul WE, Finkelmann FD (1991) Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci USA 88: 5513-5517
15. Kuhn R, Rajewsky K, Muller W (1991) Generation and analysis of interleukin 4 deficient mice. Science 254:707-710
16. Punnonen J, Aversa G, Cocks BG et al (1993) Interleukin-13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90:3730-3734
17. Burd PR, Thompson WC, Max EE, Mills FC (1995) Activated mast cells produce interleukin 13. J Exp Med 181:1371-1380
18. Köhler I, Rieber EP (1993) Allergy associated Iε and Fcβ receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element. Eur J Immunol 23:3066-3071
19. Ivashkiv LB (1995) Cytokines and STATs: how can signals achieve specificity. Immunity 3:1-4
20. Köhler I, Alliger P, Minty A et al (1994) Human interleukin-13 activates the interleukin-4 dependent transcription factor NF-IL-4 sharing a DNA binding motif with an interferon-induced nuclear binding factor. FEBS Lett 345:187-192
21. Shimoda K, van Deursen J, Sangster MY et al (1996) Lack of IL-4 induced TH2 response and IgE class switching in mice with disrupted STAT6 gene. Nature 380:630-633
22. Alderson MR, Armitage RJ, Tough TW, Strockbine L, Fanslow WC, Spriggs M (1993) CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp Med 178:669-674
23. Hess S, Rensing-Ehl A, Schwabe R, Butler P, Engelmann H (1995) CD40 function in nonhematopoetic cells. J Immunol 155:4588-4595
24. Karmann K, Huges CCW, Schechner J, Fanslow WC, Pober JS (1995) CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci USA 92:4342-4346
25. Castigli E, Alt F, Davidson L et al (1994) CD40 deficient mice generated by RAG-2 deficient blastocyst complementation. Proc Natl Acad Sci USA 91:12135-12139
26. Rousset F, Garcia E, Banchereau J (1991) Cytokine-induced proliferation and Immunoglobulin production of human B-lymphocytes triggered through their CD40 antigen. J Exp Med 173:705-710
27. Gauchat JF, Henchow S, Mazzel G et al (1993) Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365:340-343
28. Lane P, Traunecker A, Hueble S, Inui S, Lanzavecchia A, Gray A (1992) Activated human T cells express a ligand for the human B cell associated antigen CD40 which participate in T cell dependent activation of B lymphocytes. Eur J Immunol 1992:2573-2578
29. Fuleihan R, Ramesh N, Loh R et al (1993) Defective expression of the CD40 ligand in X-chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc Natl Acad Sci USA 90:2170-2173
30. Korthäuer U, Graf D, Mages HW et al (1993) Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 361:539-541
31. Weiss SJ, Zeng FF, Bonagura VR (1996) Hyper-IgM syndrome (HIgMs): a B-cell defect. J Allergy Clin Immunol 97:393
32. Kimata H, Yoshida A, Ishioka C, Lindley I, Mikawa H (1992) Interleukin-8 (IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells. J Exp Med 176: 1227-1231
33. Kiniwa M, Gately M, Gubler U, Chizzonite R, Fargeas C, Delespesse G (1992) Recombinant interleukin-12 suppresses the of immunoglobulin E by interleukin-4 stimulated human lymphocytes. J Clin Invest 90:262-266
34. Punnonen J, de Waal Malefyt R, van Vlasselaer P, Gauchat JF, de Vries JE (1993) IL-10 and viral IL-10 prevent IL-4 induced IgE synthesis by inhibiting the accessory cell function of monocytes. J Immunol 151:1280-89
35. Wu CY, Brinkmann V, Cox D (1992) Modulation of human IgE synthesis by transforming growth factor β. Clin Immunol Immunopathol 62:277-284
36. Souillet G, Rousset F, de Vries JE (1989) Alpha interferon treatment of a patient with hyper IgE-syndrome. Lancet 11:1384
37. MacKie R (1990) Interferon-α for atopic dermatitis. Lancet 335:1282-83
38. Reinhold U, Wehrmann W, Kukel S, Kreysel HW (1990) Recombinant interferon-γ in severe atopic dermatitis. Lancet 335:1282
39. Vercelli D, Jabara H, Arai K (1989) Endogenous IL-6 plays an obligatory role in IL-4 induced human IgE synthesis. Eur J Immunol 19:1419-1424
40. Pene J, Roussel F, Briere F (1988) Interleukin 5 enhances interleukin-4 induced IgE production by normal human B cells. The role of soluble CD23 antigen. Eur J Immunol 188: 929-935
41. Aversa G, Punnonen J, deVries JE (1993) The 26-kD transmembrane form of tumor necrosis factor α on activated CD4+ T cell clones provides a costimulatory signal for human B cell activation. J Exp Med 177:1575-1585
42. Gauchat J-F, Aversa G, Gascan H, deVries JE (1991) Modulation of IL-4 induced germline ε RNA synthesis in human B cells by tumor necrosis factor-α, anti-CD40 monoclonal antibodies or transforming growth factor-β correlates with levels of IgE production. Int Immunol 4(3):397-406
43. Gascan H, Gauchat JF, Aversa G, van Vlasselaer P, de Vries JE (1991) Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signalling pathways. J Immunol 147:8
44. Xu L, Rothmann P (1994) INFγ represses ε germline transcrition and subsequently downregulates switch recombination to ε. Int Immunol 6:515-521
45. Shanebeck KD, Maliszewski CR, Kennedy MK et al (1995) Regulation of murine B cell growth and differentiation by CD30 ligand. Eur J Immunol 25:2147-2153
46. Snapper CM, Zelazowski P, Rosas FR et al (1996) B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germline CH transcription, and Ig class switching. J Immunol 156:183-191
47. Sarfati M, Delespesse G (1988) Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE. J Immunol 141:2195-2199
48. Bonnefoy JY, Shields J, Mermod JJ (1990) Inhibition of human interleukin-4 induced IgE synthesis by a subset of antiCD23/Fc epsilon RII monoclonal antibodies. Eur J Immunol 20:139-144
49. Flores-Romo L, Shields J, Humbert Y et al (1993) Inhibition of an in vivo antigen-specific IgE response by antibodies to CD23. Science 261:1038-1041
50. Aubry JP, Pochon S, Graber P (1992) CD2I is a ligand for CD23 and regulates IgE-production. Nature 358:505-507
51. Vercelli D, Jabara H, Arai KI, Geha R (1989) Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class antigens. J Exp Med 169:1295-1307
52. Diaz-Sanchez D, Chegini S, Zhang K, Saxon A (1994) CD58 (LFA-3) stimulation provides a signal for human isotype switching and IgE production distinct from CD40. J Immunol 153:10-20
53. Life P, Aubry JP, Estoppey S, Schuriger V, Bonnefoy J-Y (1995) CD28 functions as an adhesion molecule and is involved in the regulation of human IgE synthesis. Eur J Immunol 25:333-339
54. Jabara HH, Ahern D, Vercelli D, Geha RS (1991) Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. J Exp Med 147:1557-1560
55. Zieg G, Lack G, Harbeck RJ, Gelfand EW, Leung DYM (1994) In vivo effects of glucocorticoids on IgE production. J Allergy Clin Immunol 94:222-230
56. Byron KA, Varigos G, Wootton A (1992) Hydrocortisone inhibition of human interleukin-4. Immunology 77:624-626
57. Kimata H, Lindley I, Furusho K (1995) Effect of hydrocortisone on spontaneous IgE and IgG4 production in atopic patients. J Immunol 154:3557-66
58. Kimata H, Yoshida A, Fujimoto M, Mikawa H (1993) Effect of vasoactive intestinal peptide, somatostatin, and substance P on spontaneous IgE and IgG4 production in atopic patients. J Immunol 150:4630-4640
59. Garrone P, Galibert L, Rousset F, Fu SM, Banchereau J (1994) Regulatory effects of prostaglandin E2 on the growth and differentiation of human B lymphocytes activated through their CD40 antigen. J Immunology 152:4282-4290
60. Kimata H (1995) Differential effects on gangliosides on human IgE and IgG4 production. Eur J Immunol 25:302-305
61. Fuleihan R, Ramesh N, Horner A et al (1994) Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J Clin Invest 93:1315-1320
62. Mizoguchi M, Kawaguchi K, Ohsuga Y, Ikari Y, Yanagawa A, Mizushima Y (1992) Cyclosporin ointment for psoriasis and atopic dermatitis. Lancet 339:1120
63. Loh RKS, Jabara HH, Geha RS (1994) Disodium chromoglycate inhibits Sm-Se deletional switch recombination and IgE synthesis in human B cells. J Exp Med 180:663-671
64. Aversa G, Punnonen J, Cocks BG et al (1993) An IL-4 mutant protein inhibits both IL-4 or IL-13 induced human IgG4 and IgE synthesis and B cell proliferation. J Exp Med 178:2213-2218
65. Carballido JM, Schols D, Namikava R et al (1995) IL-4 induces human B cell maturation and IgE synthesis in SCID-humice. Inhibition of ongoing IgE production by in vivo treatment with an IL-4/IL-13 receptor antagonist. J Immunol 155:4162-4170
66. Briner TJ, Kuo MC, Keating KM, Rogers BL, Greenstein JL (1993) Peripheral T cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I. Proc Natl Acad Sci USA 90:7608-7612
67. Cockcroft DW, Kalra S, Bhagat R et al (1996) rhuMAb-E25 (E25). humanized murine monoclonal anti-IgE. inhibits the allergen induced early asthmatic response (EAR). J Allergy Clin Immunol 97(1):315
68. Katada Y, Tanaka T, Ochi H, Aitani M, Yokota A, Kikutani H, Suemura M, Kishimoto T (1996) B cell-B cell interaction through intercellular adhesion molecule-1 and lymphocyte functional antigen-1 regulates immunglobulin E synthesis by cells stimulated with interleukin-4 and anti-CD40 antibody. Eur J Immunol 26:192-200