Autoregulation enables different pathways to control CCAAT/enhancer binding protein β (C/EBPβ) transcription

Journal of Molecular Biology

Volumn 309, Issue 4, 2001, Pages 855-868

  Niehof, Monika ^a   Kubicka, Stefan ^a   Zender, Lars ^a   Manns, Michael P ^a   Trautwein, Christian ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

cAMP responsive element (CRE) like site; cAMP responsive element binding protein (CREB); Liver enriched transcriptional activating protein (LAP); Nuclear factor kappa B (NF B); Proteinkinase A (PKA)

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; AUTOREGULATION; CYCLIC AMP RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

EID: 0035876432     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4708     Document Type: Article

References (48)

1. Biological role of the CCAAT/enhancer-binding protein family of transcripton factors
2. An essential role for C/EBPβ in female reproduction
3. CCCAAT/enhancer binding protein beta is a neuronal transcriptional regulator activated by nerve growth factor receptor signaling
4. cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to translocate to the nucleus and induce c-fos transcription
5. Phosphorylation at threonine 235 by ras-dependent mitogen activated protein cascade is essential for transcription factor NF-IL6
6. Transactivation by LAP/NF-IL6 is enhanced by phosphorylation of its activation domain
7. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ
8. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha
9. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction
10. The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor
11. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CART/enhancer-binding proteins and directs their binding to cAMP response elements
12. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro
13. The C/EBP family of transcription factors in the liver and other organs
14. CREB controls LAP/C/EBPβ transcription
15. CAAT/enhancer binding protein is able to bind to ATF/CRE elements
16. Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP)
17. An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic control in transgenic mice
18. CCCAAT/enhancer-binding protein beta is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter
19. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos
20. Transactivation of LAP/NF-IL6 is mediated by an acid domain in the N-terminal part of the protein
21. Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes
22. NF-κB: A lesson in family values
23. Autoregulation - A common property of eukaryotic transcription factors?
24. CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
25. High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors
26. CCAAT/enhancer-binding protein delta gene expression is mediated by autoregulation through downstream binding sites
27. Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding
28. The v-Myb oncoprotein activates C/EBPβ expression by stimulating an at the C/EBPβ promoter
29. Autoregulated induction of the acute-phase response transcription factor gene, agp/ebp
30. Transcription of a minimal promoter from the NF-IL6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells
31. Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin I beta gene
32. The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation
33. Complexes containing activating transcription factor (ATF)/CAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
34. ATF-2 and C/EBPalpha can form a heterodimeric DNA binding complex in vitro. Functional implications for transcriptional regulation
35. NF-IL6 and NF-kappa B in cytokine gene regulation
36. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
37. Functional and physical associations between NF-kappa B and C/EBP family members: A Rel domain-bZIP interaction
38. Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (ReIA) and NF-IL-6
39. Transcriptional induction of the agp/ebp (c/ebp beta) gene by hepatocyte growth factor
40. Identification of a C/EBP-Rel complex in avian lymphoid cells
41. Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBP beta) and NF-kappaB or Nopp140
42. Regulatory squelching
43. Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators
44. The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter
45. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
46. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements
47. C/EBP-beta/LAP controls down-regulation of albumin gene transcription during liver regeneration
48. The interplay of DNA-binding proteins on the promoter of the mouse albumin gene