Carotenoids and protection against solar UV radiation

Skin Pharmacology and Applied Skin Physiology

Volumn 15, Issue 5, 2002, Pages 291-296

  Stahl, Wilhelm ^a   Sies, Helmut ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Antioxidants; Carotenoids; Cell culture; Erythema; Oxidative stress; Photooxidation; Protection; Sunburn; UV light

Indexed keywords

ALPHA CAROTENE; ALPHA TOCOPHEROL; BETA CAROTENE; CAROTENOID; CRYPTOXANTHIN; LYCOPENE; PEROXY RADICAL; SCAVENGER; SINGLET OXYGEN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; XANTHOPHYLL; ZEAXANTHIN;

ANTIOXIDANT ACTIVITY; CONFERENCE PAPER; DRUG EFFECT; DRUG EFFICACY; ERYTHEMA; FIBROBLAST CULTURE; HUMAN; IN VITRO STUDY; PHOTOOXIDATION; PRIORITY JOURNAL; PROTEIN DIET; RADIATION EXPOSURE; RADIATION PROTECTION; SKIN PROTECTION; SOLAR RADIATION; TOMATO; TREATMENT OUTCOME; ULTRAVIOLET RADIATION; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION;

ANIMALS; ANTIOXIDANTS; BETA CAROTENE; CAROTENOIDS; HUMANS; LUTEIN; SUNBURN; ULTRAVIOLET RAYS;

EID: 0036378945     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064532     Document Type: Conference Paper

References (41)

1. Wenk J, Brenneisen P, Meewes C, Wlaschek M, Peters T, Blaudschun R, Ma W, Kuhr L, Schneider L, Scharffetter-Kochanek K: UV-induced oxidative stress and photoaging. Curr Probl Dermatol 2001;29:83-94.
2. Klotz LO, Holbrook NJ, Sies H: UVA and singlet oxygen as inducers of cutaneous signaling events. Curr Probl Dermatol 2001;29:95-113.
3. Berneburg M, Krutmann J: Photoimmunology, DNA repair and photocarcinogenesis. J Photochem Photobiol B 2000;54:87-93.
4. Thiele JJ, Schroeter C, Hsieh SN, Podda M, Packer L: The antioxidant network of the stratum corneum. Curr Probl Dermatol 2001;29:26-42.
5. Landrum JT, Bone RA: Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys 2001;385:28-40.
6. Stahl W, Sies H: Protection against solar radiation - protective properties of antioxidants; in Gacomoni PU (ed): Sun Protection in Man. Amsterdam, Elsevier, 2002, pp 561-572.
7. Sies H: Biochemistry of oxidative stress. Angew Chem Int Ed 1986;25:1058-1071.
8. Truscott TG: The photophysics and photochemistry of the carotenoids. J Photochem Photobiol B Biol 1990;6:359-371.
9. Mathews-Roth MM, Pathak MA, Fitzpatrick TB, Harber LC, Kass EH: β-Carotene as an oral protective agent in erythropoietic protoporphyria. J Am Med Assoc 1974;228:1004-1008.
10. Mathews-Roth MM: Systemic photoprotection. Dermatol Clin 1986;4:335-339.
11. Stahl W, Sies H: Physical quenching of singlet oxygen and cis-trans isomerization of carotenoids. Ann NY Acad Sci 1993;691:10-19.
12. Di Mascio P, Kaiser S, Sies H: Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989;274:532-538.
13. Stahl W, Nicolai S, Briviba K, Hanusch M, Broszeit G, Peters M, Martin H-D, Sies H: Biological activities of natural and synthetic carotenoids: Induction of gap junctional communication and singlet oxygen quenching. Carcinogenesis 1997;18:89-92.
14. Baltschun D, Beutner S, Briviba K, Martin H-D, Paust J, Peters M, Röver S, Sies H, Stahl W, Steigel A, Stenhorst F: Singlet oxygen quenching abilities of carotenoids. Liebigs Ann 1997:1887-1893.
15. Stahl W, Sundquist AR, Hanusch M, Schwarz W, Sies H: Separation of β-carotene and lycopene geometrical isomers in biological samples. Clin Chem 1993;39:810-814.
16. Stahl W, Heinrich U, Jungmann H, von Laar J, Schietzel M, Sies H, Tronnier H: Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene. J Nutr 1998;128:903-907.
17. Peng YM, Peng YS, Lin Y: A nonsaponification method for the determination of carotenoids, retinoids, and tocopherols in solid human tissues. Cancer Epidemiol Biomarkers Prev 1993;2:139-144.
18. Wingerath T, Sies H, Stahl W: Xanthophyll esters in human skin. Arch Biochem Biophys 1998;355:271-274.
19. Stahl W, Heinrich U, Jungmann H, Sies H, Tronnier H: Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am J Clin Nutr 2000;71:795-798.
20. Stahl W, Heinrich U, Wiseman S, Eichler O, Sies H, Tronnier H: Dietary tomato paste protects against UV-induced erythema in humans. J Nutr 2001;131:1449-1451.
21. Garmyn M, Ribaya-Mercado JD, Russell RM, Bhawan J, Gilchrest BA: Effect of beta-carotene supplementation on the human sunburn reaction. Exp Dermatol 1995;4:104-111.
22. Wolf C, Steiner A, Hönigsmann H: Do oral carotenoids protect human skin against ultraviolet erythema, psoralen phototoxicity, and ultraviolet-induced DNA damage? J Invest Dermatol 1988;90:55-57.
23. Gollnick HPM, Hopfenmüller W, Hemmes C, Chun SC, Schmid C, Sundermeier K, Biesalski HK: Systemic beta-carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: Results of the Berlin-Eilath study. Eur J Dermatol 1996;6:200-205.
24. Mathews-Roth MM, Pathak MA, Parrish JA, Fitzpatrick TB, Kass EH, Toda K, Clemens W: A clinical trial of the effects of oral beta-carotene on the responses of human skin to solar radiation. J Invest Dermatol 1972;59:349-353.
25. Lee J, Jiang S, Levine N, Watson RR: Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc Soc Exp Biol Med 2000;223:170-174.
26. Godar DE, Wengraitis SP, Shreffler J, Sliney DH: UV doses of Americans. Photochem Photobiol 2001;73:621-629.
27. Godar DE: UV doses of American children and adolescents. Photochem Photobiol 2001;74:787-793.
28. Sies H, Stahl W: Vitamins E and C, β-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 1995;62:1315S-1321S.
29. Krinsky NI: The antioxidant and biological properties of the carotenoids. Ann NY Acad Sci 1998;854:443-447.
30. Young AJ, Lowe GM: Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys 2001;385:20-27.
31. Lowe GM, Booth LA, Young AJ, Bilton RF: Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Radic Res 1999;30:141-151.
32. Palozza P, Luberto C, Calviello G, Ricci P, Bartoli GM: Antioxidant and prooxidant role of beta-carotene in murine normal and tumor thymocytes: Effects of oxygen partial pressure. Free Radic Biol Med 1997;22:1065-1073.
33. Biesalski HK, Obermueller-Jevic UC: UV light, beta-carotene and human skin - beneficial and potentially harmful effects. Arch Biochem Biophys 2001;389:1-6.
34. Mayne ST: β-Carotene, carotenoids, and disease prevention in humans. FASEB J 1996;10:690-701.
35. Pryor WA, Stahl W, Rock CL: Beta carotene: From biochemistry to clinical trials. Nutr Rev 2000;58:39-53.
36. Omaye ST, Krinsky NI, Kagan VE, Mayne ST, Liebler DC, Bidlack WR: β-Carotene: Friend or foe? Fundam Appl Toxicol 1997;40:163-174.
37. Woodall AA, Britton G, Jackson MJ: Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: Relationship between carotenoid structure and protective ability. Biochim Biophys Acta 1997;1336:575-586.
38. Burton GW, Ingold KU: β-Carotene: An unusual type of lipid antioxidant. Science 1984;224:569-573.
39. Zhang P, Omaye ST: Antioxidant and prooxidant roles for beta-carotene, alpha-tocopherol and ascorbic acid in human lung cells. Toxicol in vitro 2001;15:13-24.
40. Obermüller-Jevic UC, Francz PI, Frank J, Flaccus A, Biesalski HK: Enhancement of the UVA induction of haem oxygenase-1 expression by beta-carotene in human skin fibroblasts. FEBS Lett 1999;460:212-216.
41. Eichler O, Sies H, Stahl W: Divergent optimum levels of lycopene, β-carotene and lutein protecting against UVB irradiation in human fibroblasts. Photochem Photobiol 2002;75:503-506.