Rapid association of cytoskeletal remodeling proteins with the developing phagosomes of human neutrophils

Histochemistry and Cell Biology

Volumn 118, Issue 2, 2002, Pages 117-125

  Robinson, John M ^b   Badwey, John A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Neutrophils; Phagocytosis; p21 activated kinase

Indexed keywords

ACTIN; COFILIN; CYTOSKELETON PROTEIN; GUANOSINE TRIPHOSPHATASE; WISKOTT ALDRICH SYNDROME PROTEIN; ACTIN BINDING PROTEIN; ACTIN DEPOLYMERIZING FACTOR; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; NCK PROTEIN; ONCOPROTEIN; P21 ACTIVATED KINASE 2; PROTEIN CDC42; PROTEIN SERINE THREONINE KINASE; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS;

ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MOLECULAR MECHANICS; NEUTROPHIL; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PSEUDOPODIUM; ELECTRON MICROSCOPY; FOCAL ADHESION; LEUKOCYTE ACTIVATION; METABOLISM; ULTRASTRUCTURE;

CANDIDA; CANDIDA ALBICANS;

ACTIN DEPOLYMERIZING FACTORS; CDC42 GTP-BINDING PROTEIN; CYTOSKELETAL PROTEINS; FOCAL ADHESIONS; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HUMANS; MICROFILAMENT PROTEINS; MICROSCOPY, ELECTRON; NEUTROPHIL ACTIVATION; NEUTROPHILS; ONCOGENE PROTEINS; PHAGOCYTOSIS; PHAGOSOMES; PROTEIN-SERINE-THREONINE KINASES;

EID: 0036373779     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-002-0440-0     Document Type: Article

References (57)

1. Activation of the NADPH oxidase involves the small GTP-binding protein p21-rac1
2. Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane
3. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
4. Mechanisms of phagocytosis
5. Comparative aspects of oxidative metabolism of neutrophils from human blood and guinea pig peritonea: Magnitude of the respiratory burst, dependence upon stimulating agents, and localization of the oxidases
6. Cytochalasin E diminishes the lag phase of superoxide release by human neutrophils
7. Putting a new twist on actin: ADF/cofilins modulate actin dynamics
8. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
9. Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins
10. Interaction of the Nck adapter protein with p21-activated kinase 1 (Pak1)
11. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
12. Chemoattractant stimulated polymorphonuclear leukocytes contain two populations of actin filaments that differ in their spatial distribution and relative stabilities
13. Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion
14. How is actin polymerization nucleated in vivo?
15. Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fc receptor signalling during phagocytosis
16. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
17. NADPH oxidase activation and assembly during phagocytosis
18. Localization of p21-activated kinase1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils
19. Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C-kinase substrate
20. Differential effects of Pak1-activating mutations reveal activity-dependent and independent effects on cytoskeletal regulation
21. Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils
22. Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages
23. Rho GTPases and the actin cytoskeleton
24. A novel role for Rho-GDI as an inhibitor of GAP proteins
25. Interaction of paxillin with p21-activated kinase (PAK). Association of paxillin-α with the kinase-inactive and the Cdc42-activated forms of Pak3
26. 52 Neisseria gonorrhoeae requires an Src-like tyrosine kinase- and Rac1-dependent signaling pathway
27. Cofilin undergoes rapid dephosphorylation in stimulated neu-trophils and translocates to ruffled membranes enriched in products of the NADPH oxidase complex. Evidence for a novel cycle of phosphorylation and dephosphorylation
28. Activation by Cdc42 and PIP2 of Wiskott-Aldrich Syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
29. Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): Separate signals are required for activation and inactivation of Paks
30. Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex
31. Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid Fcγ RII signaling
32. Substrates enhance autophosphorylation and activation of p21-activated protein kinase γ-Pak in the absence of activation loop phosphorylation
33. 2 avidity in polymorphonuclear neutrophils
34. Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages
35. GTPgammaS-induced actin polymerization in vitro: ATP- and phosphoinositide-independent signalling via Rho-family proteins and a plasma membrane-associated guanine nucleotide exchange factor
36. Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac2
37. Regulation of human leukocyte p21-activated kinases through G-protein coupled receptors
38. Interaction of a G-protein β-subunit with a conserved sequence in Ste20/Pak family protein kinases
39. Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: Novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade
40. Phosphorylation of the activation loop of γp21-activated kinase (γ-Pak) and related kinases (MSTs) in normal and stressed neutrophils
41. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in induction of actin assembly in Xenopus egg extracts
42. Rocket-based motility: A universal mechanism?
43. A brain serine/threonine protein kinase activated by Cdc42 and Rac1
44. Expression of constitutively active α-Pak reveals effects of the kinase on actin and focal complexes
45. Pak kinases are directly coupled to the PIX family of nucleotide exchange factors
46. Involvement of the Arp2/3 complex in phagocytosis mediated by Fc R or CR3
47. Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood
48. The NADPH oxidase complex of phagocytic leukocytes: A biochemical and cytochemical view
49. Localization of cerium-based reactions using scanning confocal reflectance microscopy
50. Inhibition of the action of the stimulatory GDP/GTP exchange protein for smg 21 by the geranylgeranylated synthetic peptides designed from its C-terminal region
51. Activation induces dephosphorylation of cofilin and its translocation to the plasma membranes in neutrophil-like differentiated HL-60 cells
52. Paxillin LD4 motif binds Pak and PIX through a novel 95 kDa ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
53. Spatial control of actin polymerization during neutrophil chemotaxis
54. Profilin enhances Cdc42-induced nucleation of actin polymerization
55. Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension
56. Sensory adaptation of leukocytes to chemotactic peptides
57. Regulation of actin polymerization in cell free systems by GTPγS and Cdc42