Brain noradrenergic receptors in major depression and schizophrenia

Neuropsychopharmacology

Volumn 21, Issue 1, 1999, Pages 69-81

  Klimek, Violetta ^a   Rajkowska, Grazyna ^a   Luker, Stephen N ^a   Dilley, Ginny ^b   Meltzer, Herbert Y ^b   Overholser, James C ^b   Stockmeier, Craig A ^b   Ordway, Gregory A ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Depression; Hippocampus; Noradrenergic receptors; Postmortem; Prefrontal cortex; Schizophrenia

Indexed keywords

1 (2 CYANOPHENOXY) 3 [2 (3 PHENYLUREIDO)ETHYLAMINO] 2 PROPANOL; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ALCOHOL; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CLONIDINE; COCAINE; DIAZEPAM; DIHYDROALPRENOLOL; IODOPINDOLOL I 125; ISOPRENALINE; LIDOCAINE; NORADRENALIN; PARACETAMOL; PHENYTOIN; PROPRANOLOL; TEMAZEPAM;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; AUTOPSY; AUTORADIOGRAPHY; CLINICAL ARTICLE; DEPRESSION; FEMALE; HIPPOCAMPUS; HUMAN; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR DENSITY; SCHIZOPHRENIA; SUICIDE;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADULT; AFFINITY LABELS; AGED; AUTORADIOGRAPHY; BRAIN CHEMISTRY; CLONIDINE; DEPRESSIVE DISORDER; FEMALE; HIPPOCAMPUS; HUMANS; IODINE RADIOISOTOPES; MALE; MIDDLE AGED; NOREPINEPHRINE; PINDOLOL; PREFRONTAL CORTEX; RECEPTORS, ADRENERGIC; SCHIZOPHRENIA; SUICIDE;

EID: 0033019644     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(98)00134-1     Document Type: Article

References (76)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, Revised. 1987;American Psychiatric Association, Washington, DC.
2. Andreasen N.C., Endicott J., Spitzer R.L., Winokur G. The family history method using diagnostic criteria. Reliability and validity. Arch Gen Psychiat. 34:1977;1229-1235.
3. Aoki C., Go C.G., Venkatesan C., Kurose H. Perikaryal and synaptic localization of α2-adrenergic receptor-like immunoreactivity. Brain Res. 650:1994;181-204.
4. Arango V., Ernsberger P., Marzuk P.M., Chen J.S., Tierney H., Stanley M., Reis D.J., Mann J.J. Autoradiographic demonstration of increased serotonin 5-HT2 and Beta-adrenergic receptor binding sites in the brain of suicide victims. Arch Gen Psychiat. 47:1990;1038-1047.
5. Arango V., Ernsberger P., Sved A.F., Mann J.J. Quantitative autoradiography of α1 and α2 adrenergic receptors in the cerebral cortex of controls and suicide victims. Brain Res. 630:1993;271-282.
6. Archer T., Cotic T., Järbe T.U.C. Attenuation of the context effect and lack of unconditioned stimulus-pre-exposure effect in the taste-aversion learning following treatment with DPP4, the selective noradrenaline neurotoxin. Behav Neural Biol. 35:1982;159-173.
7. Aston-Jones G., Shipley M.T., Chouvet G., Ennis M., van Bockstaele E., Pierbone V., Shiekhattar R., Akaoka H., Drolet G., Astier B., Charlety P., Valentino R.J., Williams J.T. Afferent regulation of locus coeruleus neurons. Anatomy, physiology, and pharmacology Prog Brain Res. 88:1991;47-75.
8. Barturen F., Garcia-Sevilla J.A. Long-term treatment with desipramine increases the turnover of α2-adrenoceptors in the rat brain. Mol Pharmacol. 42:1992;846-855.
9. Benes F.M., Sorensen I., Bird E.D. Reduced neruonal size in posterior hippocampus of schizophrenic patients. Schizophr Bull. 17:1991;597-608.
10. Biegon A., Israeli M. Regionally selective increases in β-adrenergic receptor density in the brains of suicide victims. Brain Res. 442:1988;199-203.
11. Bird O.E., Spokes E.G., Iversen L.L. Brain norepinephrine and dopamine in schizophrenia. Science. 204:1979;456.
12. Bogerts B., Meertz E., Schoenfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia. Morphometric study of brain volume shrinkage Arch Gen Psychiat. 42:1985;784-791.
13. Bylund D.B. Regulation of central adrenergic receptors. Adv Exper Med Biol. 116:1979;133-162.
14. Bylund D.B. Heterogeneity of alpha-2 adrenergic receptors. Pharmacol Biochem Behav. 22:1985;835-843.
15. Bylund D.B. Subtypes of alpha 2-adrenoceptors. Pharmacological and molecular biological evidence converge Trends Pharmacol Sci. 9:1988;356-361.
16. Bylund D.B., Martinez J.R. Alpha 2-adrenergic receptors appear in rat salivary glands after reserpine treatment. Nature. 285:1980;229-230.
17. 2A-adrenoceptor agonist binding sites in brains of depressed suicide victims. J Neurochem. 70:1998;1114-1123.
18. Crow T.J., Cross A.J., Cooper S.J., Deakin J.F.W., Ferrier I.N., Johnson J.A., Joseph M.H., Owen F., Poulter M., Lofthouse R., Corsellis J.A.N., Chambers D.R., Blessed G., Perry E.K., Perry R.H., Tomlinson B.E. Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology. 23:1984;1561-1569.
19. Dausse J.P., Le Quan-Bui K.H., Meyer P. Alpha 1- and alpha 2-adrenoceptors in rat cerebral cortex. Effects of neonatal treatment with 6-hydroxydopamine Eur J Pharmacol. 78:1982;15-20.
20. De Paermentier F., Cheetham S.C., Crompton M.R., Katona C.L., Horton R.W. Brain beta-adrenoceptor binding sites in antidepressant-free depressed suicide victims. Brain Res. 525:1990;71-77.
21. 2B-adrenoceptor subtypes in postmortem human brain. J Neurochem. 58:1992;1555-1560.
22. Duvernoy H.M. The Human Hippocampus. 1988;J. F. Bergmann Verlag, Munich.
23. Endicott J., Spitzer R.L. A diagnostic interview. The schedule for affective disorders and schizophrenia Arch Gen Psychiat. 35:1978;837-844.
24. Falkai P., Bogerts B., Rozumek M. Limbic pathology in schizophrenia. The entorhinal region - A morphometric study Biol Psychiat. 24:1988;515-521.
25. Falkai P., Bogerts B. Cell loss in the hippocampus of schizophrenics. Eur Arch Psychiat Neurol Sci. 236:1986;154-161.
26. Farley I.J., Price K.S., McCullough E., Deck J.H.N., Hordynski W., Hornykiewicz O. Norepinephrine in chronic paranoid schizophremia. Above-normal levels in limbic forebrain Science. 200:1978;456-457.
27. Ferrier I.N., McKeith I.G., Cross A.J., Perry E.K., Candy J.M., Perry R.H. Postmortem neurochemical studies in de-pression. Ann N Y Acad Sci. 487:1986;128-142.
28. Ferrier I.N., Perry E.K. Postmortem studies in affective disorder. Psychological Med. 22:1992;835-838.
29. 125I]Iodoclonidine is a partial agonist at the α2-adrenergic receptor. Mol Pharmacol. 38:1990;214-221.
30. Gomes U.C.R., Shanley B.C., Potgieter L., Roux J.T. Noradrenergic overactivity in chronic schizophrenia. Evidence based on cerebrospinal fluid noradrenaline and cyclic nucleotide concentrations Brit J Psychiat. 137:1980;346-351.
31. 2-adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims. J Neurochem. 63:1994;256-265.
32. 3H-rauwolscine to cortical membranes. Naunyn-Schmiedeberg's Arch Pharmacol. 328:1985;229-235.
33. Harrison J.K., D'Angelo D.D., Zeng D.W., Lynch K.R. Pharmacological characterization of rat alpha 2-adrenergic receptors. Mol Pharmacol. 40:1991;407-412.
34. Hornykiewicz O. Brain catecholamines in schizophrenia - A good case for noradrenaline. Nature. 299:1982;484-485.
35. Hornykiewicz O. Brain Noradrenaline and Schizophrenia. van Ree J.M., Matthysse S.W. Progress in Brain Research. 1986;29-39 Elsevier, Vienna.
36. Joyce J.N., Lexow N., Kim S.J., Artymyshyn R., Senzon S., Lawrence D., Cassanova M.F., Kleinman J.E., Bird E.D., Winokur A. Distribution of beta-adrenergic receptor subtypes in human postmortem brain. Alterations in limbic regions of schizophrenics Synapse. 10:1992;228-246.
37. Kelly T.M., Mann J.J. Validity of DSM-III-R diagnosis by psychological autopsy. A comparison with clinician antemortem diagnosis Acta Psychiat Scand. 94:1996;337-343.
38. Klimek V., Stockmeier C.A., Overholser J.C., Meltzer H.Y., Kalka S., Dilley G., Ordway G.A. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J Neurosci. 17:1997;8451-8458.
39. Kovachich G.B., Frazer A., Aronson C.E. Effect of chronic administration of antidepressants on alpha 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography. Neuropsychopharmacology. 8:1993;57-65.
40. Lake C.R., Sternberg D.E., vanKammen D.P., Ballenger J.C., Ziegler M.G., Post R.M., Kopin I.J., Bunney W.E. Schizophrenia. Elevated cerebrospinal fluid norepinephrine Science. 207:1980;331-333.
41. Lake C.R., Pickar D., Ziegler M.G., Lipper S., Slater S., Murphy D.L. High plasma norepinephrine levels in patients with major affective disorder. Am J Psychiat. 139:1982;1315-1318.
42. Lee C.-M., Javitch J.A., Snyder S.H. Recognition sites for norepinephrine uptake. Regulation by neurotransmitter Science. 220:1983;626-629.
43. Lomasney J.W., Lorenz W., Allen L.F., King K., Regan J.W., Yang-Feng T.L., Caron M.G., Lefkowitz R.J. Expansion of the alpha 2-adrenergic receptor family. Cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2 Proc Natl Acad Sci USA. 87:1990;5094-5098.
44. 2 and β-adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiat. 43:1986;954-959.
45. Mason S.T. Noradrenaline in the brain. Progress in theories of behavioral function Prog Neurobiol. 16:1981;263-303.
46. 2-adrenoceptors in the brain of suicide victims. Increased receptor density associated with major depression Biol Psychiat. 31:1992;471-490.
47. Meana J.J., Garcia-Sevilla J.A. Increased α2-adrenoceptor density in the frontal cortex of depressed suicide victims. J Neural Transm. 70:1987;377-381.
48. Melia K.R., Rasmussen K., Terwilliger R.Z., Haycock J.W., Nestler E.J., Duman R.S. Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus. Effects of chronic stress and drug treatments J Neurochem. 58:1992;494-502.
49. Melia K.R., Duman R.S. Involvement of corticotropin-releasing factor in chronic stress regulation of the brain noradrenergic system. Proc Natl Acad Sci USA. 88:1991;8382-8386.
50. Nicholas A.P., Pieribone V., Hokfelt T. Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain. An in situ hybridization study J Comp Neurol. 328:1993;575-594.
51. 2-adrenoceptors in rat brain. J Neurochem. 64:1995;1118-11261.
52. Ordway G.A., Gambarana C., Frazer A. Quantitative autoradiography of central beta adrenoceptor subtypes. Comparison of the effects of chronic treatment with desipramine or centrally administered l-isoproterenol J Pharmacol Exp Ther. 247:1988;379-389.
53. 125I-iodopindolol to beta-1 adrenoceptors in the amygdala of rat after antidepressant treatments. J Pharmacol Exp Ther. 257:1991;681-690.
54. Ordway G.A., Jaconetta S.M., Halaris A.E. Characterization of subtypes of alpha-2 adrenoceptors in the human brain. J Pharmacol Exp Ther. 264:1993;967-976.
55. Ordway G.A., Smith K.S., Haycock J.W. Elevated tyrosine hydroxylase in the locus coeruleus of suicide victims. J Neurochem. 62:1994;680-685. a.
56. 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide. J Neurochem. 63:1994;617-624. b.
57. 2-adrenoceptors in rat brain. J Neurochem. 64:1995;1118-1126.
58. Plaznik A., Pucilowski O., Kostowski W., Bidzinski A., Hauptmann M. Rotational behavior produced by unilateral ventral noradrenergic bundle lesions. Evidence for a noradrenergic-dopaminergic interaction in the brain Pharmacol Biochem Behav. 17:1982;619-622.
59. Prange A.J. Jr. The pharmacology and biochemistry of depression. Dis Nerv Syst. 25:1964;217-221.
60. 2-adrenergic receptors in rat cerebellum and cerebral cortex. Proc Natl Acad Sci USA. 81:1984;1585-1589.
61. Rajkowska G (1997): Morphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patients. In Stoff DM, Mann JJ (eds), The Neurobiology of Suicide. From the Bench to the Clinic. New York, New York Acad Sci 836:253-268.
62. Rajkowska G, de Vos K, Pool CW, Roland PE, Zilles K, Uylings H (1998): 3-D Cytoarchitectonic parcellation of human orbitofrontal cortex. Correlation with postmortem MRI. Soc Neurosci Abstr 24:Abstract.
63. Rajkowska G., Goldman-Rakic P.S. Cytoarchitectonic definition of prefrontal areas in the normal human cortex. I Remapping of areas. 9(and 46 using quantitative criteria. Cerebral Cortex 5):1995;307-322. a.
64. Rajkowska G., Goldman-Rakic P.S. Cytoarchitectonic definition of prefrontal areas in the normal human cortex. II. Variability in locations of areas 9 and 46 and relationship to the Talairach coordinate system Cerebr Cortex. 5:1995;323-337. b.
65. Riva M.A., Creese I. Reevaluation of the regulation of β-adrenergic receptor binding by desipramine treatment. Mol Pharmacol. 36:1989;211-218.
66. Robbins L., Cottler L., Keating S. NIMH Diagnostic Interview Schedule. Version III. Revised (DIS-III-R). 1989;MO: Washington University Department of Psychiatry, St. Louis.
67. Schildkraut J.J. The catecholamine hypothesis of affective disorders. A review of supporting evidence Am J Psychiat. 122:1965;509-522.
68. Sternberg D.E., Van Kammen D.P., Lake C.R., Ballenger J.C., Marder S.R., Bunney W.E. Jr. The effect of pimozide on CSF norepinephrine in schizophrenia. Am J Psychiat. 138:1981;1045-1050.
69. Sulser F., Gillespie D.D., Manier D.H. Physiological mechanism and significance of changes in the regulation of beta adenoceptors by antidepressants. Clin Neuropharmacol. 7:1984;304-305.
70. U'Prichard D.C., Bechtel W.D., Rouot B.M., Snyder S.H. Multiple apparent alpha-noradrenergic receptor binding sites in rat brain. Effect of 6-hydroxydopamine Mol Pharmacol. 16:1979;47-60.
71. Van Kammen D.P., Peters J., van Kammen W.B., Nugent A., Goetz K.L., Yao J., Linnoila M. CSF norepinephrine in schizophrenia is elevated prior to relapse after haloperidol withdrawal. Biol Psychiat. 26:1989;176-188.
72. Van Kammen D.P., Antelman S. Impaired noradrenergic transmission in schizophrenia? Life Sci. 34:1984;1403-1413.
73. Van Kammen D.P., Kelley M. Dopamine and norepinephrine activity in schizophrenia. An integrative perspective. Schizophr Res. 4:1991;173-191.
74. Waldmeier P.C. Noradrenergic transmission in depression. Under- or overfunction? Pharmacopsychiatria. 14:1981;3-9.
75. Weinberger D.R., Wagner R.L., Wyatt R.J. Neuropathological studies of schizophrenia. A selective review Schizophr Bull. 9:1983;193-212.
76. Zhu M.-Y., Haycock J.W., Klimek V., Luker S.N., Stockmeier C.A., Dilley G., Meltzer H.Y., Overholser J.C., Ordway G.A. Elevation of tyrosine hydroxylase in the locus coeruleus of subjects with major depression. Soc Neurosci Abs. 21:1995;194. abstract.