Tiagabine treatment and DNA damage in rat astrocytes: An in vitro study by comet assay

Neuroscience Letters

Volumn 306, Issue 1-2, 2001, Pages 17-20

  Cardile, Venera ^a   Palumbo, Maddalena ^a   Renis, Marcella ^a   Pavone, Antonino ^b   Maci, Tiziana ^a   Perciavalle, Vincenzo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b GARIBALDI HOSPITAL   (Italy)

Author keywords

Antiepileptic drugs; Comet assay; DNA damage; Glial cells; Rat; Tiagabine

Indexed keywords

DNA; DNA FRAGMENT; TIAGABINE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DAMAGE; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG MEGADOSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELLS, CULTURED; CEREBRAL CORTEX; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; GABA AGONISTS; GENOME; GLIAL FIBRILLARY ACIDIC PROTEIN; NERVE DEGENERATION; NIPECOTIC ACIDS; RATS;

EID: 0035933643     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01836-5     Document Type: Article

References (12)

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5. Tiagabine: A new therapeutic option for people with intellectual disability and partial epilepsy
6. Basic mechanisms of gabitril (tiagabine) and future potential developments
7. Detection of DNA lesions induced by chemical cell gel electrophoresis (Comet) assay. 1. Relation between the onset of DNA damage and the characteristics of mutagens
8. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors
9. A review of the antiepileptic drug tiagabine
10. The effects of antiepileptic drugs on GABA and glutamate uptake into primary cultures of rat cortical astrocytes
11. A simple technique for quantitation of low levels of DNA damage in individual cells
12. Antioxidant defense of the brain: A role for astrocytes