Halothane as a neuroprotectant during constant stimulation of the perforant path

Epilepsia

Volumn 40, Issue 3, 1999, Pages 359-364

  Walker, M C ^b   Perry, H ^c   Scaravilli, F ^c   Patsalos, P N ^c   Shorvon, S D ^c   Jefferys, J G R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

^c NONE

Author keywords

Anaesthesia; Halothane; Neuroprotection; Perforant path; Status epilepticus

Indexed keywords

HALOTHANE; KETAMINE; URETHAN;

ANESTHESIA; ANIMAL MODEL; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN TEMPERATURE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EPILEPTIC DISCHARGE; EPILEPTIC STATE; HIPPOCAMPUS; ISCHEMIA; MALE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PERFORANT NERVE TRACT; PRIORITY JOURNAL;

EID: 0032956154     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1999.tb00718.x     Document Type: Article

References (27)

1. Walker MC, Shorvon SD. Status epilepticus and serial seizures. In: Shorvon S, Dreifuss F, Fish D, Thomas D, eds The treatment of epilepsy. Oxford: Blackwell Science. 1995:269-85.
2. Jagoda A, Riggio S. Refractory status epilepticus in adults. Ann Emerg Med 1993;22:1337-8.
3. Shorvon SD. Status epilepticus: its clinical features and treatment in children and adults. Cambridge: Cambridge University Press, 1994.
4. Walker MC, Smith SJM, Shorvon SD. The intensive care treatment of convulsive status epilepticus in the UK. Anaesthesia 1995;50: 130-5.
5. Clifford DB, Zorumski CF, Olney JW. Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal seizures. Exp Neurol 1989;105:272-9.
6. Fujikawa DG. Neuroprotective effect of ketamine administered after status epilepticus onset. Epilepsia 1995;36:186-95.
7. Rogers BC, Barnes MI, Mitchell CL, Tilson HA. Functional deficits after sustained stimulation of the perforant path. Brain Res 1989;493:41-50.
8. Ylinen AM, Miettinen R, Pitkanen A, Gulyas AI, Freund TF, Riekkinen PJ. Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy. Proc Natl Acad Sci USA 1991;88:7650-3.
9. Ylinen A, Lahtinen H, Sirvio J, et al. Behavioural, electrophysiological and histopathological changes following sustained stimulation of the perforant pathway input to the hippocampus: effect of the NMDA receptor antagonist. CGP 39551. Brain Res 1991;553: 195-200.
10. Sloviter RS. "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perforant path, I. Acute electrophysiological and light microscopic studies. Brain Res Bull 1983;10:675-97.
11. Sloviter RS. Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science 1987;235:73-6.
12. Warner DS, McFarlane C, Todd MM, Ludwig P, McAllister AM. Sevoflurane and halothane reduce focal ischemic brain damage in the rat: possible influence on thermoregulation. Anesthesiology 1993;79:985-92.
13. Freund TF, Buzsaki G, Leon A, Somogyi P. Hippocampal cell death following ischaemia: effects of brain temperature and anesthesia. Exp Neurol 1990;108:251-60.
14. Errington ML, Lynch MA, Bliss TVP. Long-term potentiation in the dentate gyms: induction and increased glutamate release are blocked by D(-)aminophosphonovalerate. Neuroscience 1987;20: 279-84.
15. Racine RJ. Modification of seizure activity by electrical stimulation. II Motor seizure. Electroencephalogr Clin Neurophysiol 1972;32:281-94.
16. Williams RW, Rakic P. Three-dimensional counting: an accurate and direct method to estimate number of cells in sectioned material. J Comp Neurol 1988;278:344-52.
17. Ansari B, Coates PJ, Greenstein BD, Hall PA. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 1993;170:1-8.
18. Walker MC, Galley PT, Errington ML, Shorvon SD, Jefferys JGR. Ascorbate and glutamate release in the rat hippocampus after perforant path stimulation: a "dialysis electrode" study. J Neurochem 1995;65:725-31.
19. Bertram EH, Lothman EW. Morphometric effects of intermittent kindled seizures and limbic status epilepticus in the dentate gyrus of the rat. Brain Res 1993;603:25-31.
20. Warner DS, Ludwig PS, Pearlstein R, Brinkhous AD. Halothane reduces focal ischemic injury in the rat when brain temperature is controlled. Anesthesiology 1995;82:1237-45.
21. Richards CD, White AE. The actions of volatile anaesthetics on synaptic transmission in the dentate gyrus. J Physiol (Lond) 1975; 252:241-57.
22. 2+ transients and glutamate release in isolated cerebral synaptosomes. Anesthesiology 1995;83:593-603.
23. Gage PW, Robertson B. Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus. Br J Pharmacol 1985;85:675-81.
24. Mody I, Tanelian DL, MacIver MB. Halothane enhances tonic neuronal inhibition by elevating intracellular calcium. Brain Res 1991;538:319-23.
25. Pearce RA, Stringer JL, Lothman EW. Effect of volatile anesthetics on synaptic transmission in the rat hippocampus. Anesthesiology 1989;71:591-8.
26. Mantz J, Cordier J, Giaume C. Effects of general anesthetics on intercellular communications mediated by gap junctions between astrocytes in primary culture. Anesthesiology 1993;78:892-901.
27. Nicoll RA, Madison DV. General anesthetics hyperpolarize neurons in the vertebrate central nervous system. Science 1982;217: 1055-7.