Halothane suppression of spinal sensory neuronal responses to noxious peripheral stimuli is mediated, in part, by both GABAA and glycine receptor systems

Anesthesiology

Volumn 97, Issue 2, 2002, Pages 412-417

  Yamauchi, Masanori ^a   Sekiyama, Hiroshi ^b   Shimada, Steven G ^b   Collins, J G ^b,c  

^a Oji General Hospital   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICUCULLINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ANTAGONIST; HALOTHANE; STRYCHNINE; TOXIC GAS;

ANESTHESIA MECHANISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM DEPRESSION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; GENERAL ANESTHESIA; HEAT STRESS; INHALATION ANESTHESIA; MALE; MECHANICAL STRESS; MINIMUM LUNG ALVEOLUS CONCENTRATION; NERVE FUNCTION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; SENSORY DYSFUNCTION; STIMULUS RESPONSE;

ANESTHETICS, INHALATION; ANIMALS; BICUCULLINE; DRUG INTERACTIONS; GABA ANTAGONISTS; GLYCINE AGENTS; HALOTHANE; MALE; NEURONS, AFFERENT; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, GLYCINE; STRYCHNINE;

EID: 0036325564     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200208000-00019     Document Type: Article

References (38)

1. Myelinated afferent fibers responding specifically to noxious stimulation of the skin
2. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli
3. Spinal termination of functionally unidentified primary afferent neurons with slowly conducting myelinated fibers
4. Central projections of identified, unmyelinated afferent fibers innervating mammalian skin
5. Anesthetic potency (MAC) is independent of forebrain structures in the rat
6. Exaggerated anesthetic requirements in the preferentially anesthetized brain
7. Anesthetic potency is not altered after hypothermic spinal cord transection in rats
8. Does the brain influence somatic responses to noxious stimuli during isoflurane anesthesia?
9. Isoflurane blunts electroencephalographic and thalamic-reticular formation responses to noxious stimulation in goats
10. Isoflurance depresses electroencephalographic and medial thalamic responses to noxious stimulation via an indirect spinal action
11. Block of afferent impulses in the dorsal horn of monkey. A possible mechanism of anesthesia
12. Actions of halothane and nitrous oxide on dorsal horn neurons ("the spinal gate")
13. Effects of halothane on spinal neuronal responses to graded noxious heat stimulation in the cat
14. A receptor pharmacology
15. Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina 1 neurons of the adult rat spinal cord
16. Enhancement of gamma-aminobutyric acid-activated Cl-currents in cultured rat hippocampal neurons by three volatile anesthetics
17. General anesthetics potentiate gamma-butyric acid actions on gamma aminobutyric acid receptors expressed by xenopus oocytes: Lack of involvement of intracellular calcium
18. Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia
19. Effects of inhalational general anesthetics on native glycine receptors in rat medullary neurons and recombinant glycine receptors in Xenopus oocytes
20. Sites of alcohol and volatile anesthetic action on GABA(A) and glycine receptors
21. A receptor/chloride channel complex in anesthesia
22. Selective action of volatile general anesthetics at molecular and cellular levels
23. A receptor antagonists
24. Halothane increases the open probability of glycine activated channel current in rat central neurons
25. Post-synaptic inhibitory mechanism of anaesthesia: Glycine receptors
26. A nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane
27. A and glycine systems cooperatively mediate halothane depression of spinal dorsal horn neurons in rats
28. Direct comparison of heat-evoked activity of nociceptive neurons in the dorsal horn with the hind limb withdrawal reflex in the rat
29. Interneurons presynaptic to rat tail-flick motorneurons as mapped by transneuronal transport of pseudorabies virus: Few have long ascending collaterals
30. A or glycine receptors
31. Behavioral and anatomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists
32. Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat
33. Strichnine-sensitive modulation is selective for non-noxious somatosensory input in the spinal cord of the rat
34. Neuronal model of tactile allodynia produced by strychnine: Effects of excitatory amino acid receptor antagonists and a μ-opiate receptor agonist
35. Spinal bicuculline produces hypersensitivity of dorsal horn neurons: Effects of excitatory amino acid antagonists
36. Electrophysiologic evidence for increased endogenous GABAergic but no glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy
37. Neurophysiological characterization of the anterolateral spinal cord neurons contributing to pain perception in man