Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABA(A) or glycine receptors

Anesthesiology

Volumn 93, Issue 4, 2000, Pages 1075-1084

  Cheng, G ^a   Kendig, J J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPA receptor; Anesthetic mechanisms; NMDA receptor; Volatile anesthetic agent

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BICUCULLINE; ENFLURANE; GLUTAMIC ACID; GLYCINE RECEPTOR; INHALATION ANESTHETIC AGENT; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; TETRODOTOXIN;

ANESTHESIA MECHANISM; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL ROOT; DRUG SELECTIVITY; EXCITATORY POSTSYNAPTIC POTENTIAL; IMMOBILIZATION; INHALATION ANESTHESIA; MOUSE; NERVE CELL INHIBITION; NEWBORN; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SPINAL CORD DORSAL HORN; SPINAL CORD MOTONEURON; SYNAPTIC TRANSMISSION;

EID: 0033771317     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200010000-00032     Document Type: Article

References (53)

1. Molecular and cellular mechanisms of general anaesthesia
2. Selective action of volatile general anaesthetics at molecular and cellular levels
3. Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes
4. - currents in cultured rat hippocampal neurones by three volatile anaesthetics
5. General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acid(A) receptors expressed by Xenopus oocytes: Lack of involvement of intracellular calcium
6. Anaesthetic concentrations of alcohols potentiate GABA(A) receptor-mediated currents: Lack of subunit specificity
7. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors
8. Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia
9. Isoflurane depresses both glutamate and peptide-mediated slow synaptic transmission in neonatal rat spinal cord
10. Ethanol as a general anesthetic: Actions in spinal cord
11. Ethanol directly depresses AMPA and NMDA glutamate currents in spinal cord motor neurons independent of actions on GABAa or glycine receptors
12. Effects of halothane on glutamate receptor-mediated excitatory postsynaptic currents: A patch-clamp study in adult mouse hippocampal slices
13. Mechanism of action of volatile anesthetics: Effects of halothane on glutamate receptors in vitro
14. Presynaptic and postsynaptic actions of halothane at gutamatergic synspses in the mouse hippocampus
15. Minimum alveolar anesthetic concentration: A standard of anesthetic potency
16. Anesthetic potency is not altered after hypothermic spinal cord transection in rats
17. The relationship among brain, spinal cord and anesthetic requirements
18. Exaggerated anesthetic requirements in the preferentially anesthetized brain
19. Anesthetic potency (MAC) is independent of forebrain structures in the rat
20. Maturation decreases ethanol minimum alveolar anesthetic concentration in mice as previously demonstrated in rats: There is no species difference
21. Maturation decreases ethanol minimum alveolar anesthetic concentration (MAC) more than desflurane MAC in rats
22. Actions of general anaesthetics on synaptic transmission in the CNS
23. On the mechanism of halothane anaesthesia
24. Anaesthetics depress the sensitivity of cortical neurones to L-glutamate
25. The actions of volatile anaesthetics on synaptic transmission in the dentate gyrus
26. Inhibition of presynaptic sodium channels by halothane
27. Differential sensitivities of TTX-resistant and TTX-sensitive sodium channels to anesthetic concentrations of ethanol in rat sensory neurons
28. Volatile anesthetics depress glutamate transmission via presynaptic actions
29. Anesthetic depression of spinal motor neurons may contribute to lack of movement in response to noxious stimuli
30. Dual actions of volatile anesthetics on GABA(A) IPSCs: Dissociation of blocking and prolonging effects
31. Ethanol reduces neuronal excitability and excitatory synaptic transmission in the developing rat spinal cord
32. Halothane enhances tonic neuronal inhibition by elevating intracellular calcium
33. Corelease of two fast neurotransmitters at a central synapse
34. A-subunit of calcium/calmodulin-dependent protein kinase II enhances gamma-aminobutyric acid and inhibitory synaptic responses of rat neurons in vitro
35. Phaclofen-insensitive presynaptic inhibitory action of (+/-)-baclofen in neonatal rat motoneurons in vitro
36. Volatile anesthetics gate a chloride current in postnatal rat hippocampal neurons
37. General anesthetic agents in relation to analgesia
38. Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration
39. Actions of fluorinated alkanols on GABA(A) receptors: Relevance to theories of narcosis
40. Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat
41. The effects of general anesthetics on excitatory and inhibitory synaptic transmission in area CA1 of the rat hippocampus in vitro
42. Ethanol inhibition of neuronal glutamate receptor function
43. Ethanol inhibits NMDA-activated ion current in hippocampal neurons
44. Cutoff in potency implicates alcohol inhibition of N-methyl-D-asparate receptors in alcohol intoxication
45. Anesthetics produce subunit-selective actions on glutamate receptors
46. Pentobarbitone modulation of NMDA receptors in neurones isolated from the rat olfactory brain
47. Effects of isoflurane on N-methyl-D-aspartate gated ion channels in cultured rat hippocampal neurons
48. How does xenon produce anaesthesia?
49. A serious target for laughing gas
50. Effects of ethanol on ion channels
51. Alcohols and neurotransmitter gated ion channels: Past, present and future
52. Inhibition by ethanol of excitatory amino acid receptors in rat locus coeruleus neurons in vitro
53. Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon