Spinal bicuculline produces hypersensitivity of dorsal horn neurons: Effects of excitatory amino acid antagonists

Pain

Volumn 77, Issue 2, 1998, Pages 181-190

  Sorkin, Linda S ^a   Puig, Sylvie ^a   Jones, Denise L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cat; GABA; Neuropathic pain; Pain; Spinal cord

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMINO ACID RECEPTOR BLOCKING AGENT; BICUCULLINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

AFTERDISCHARGE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CAT; CONTROLLED STUDY; FEMALE; HYPERSENSITIVITY; MALE; MECHANICAL STIMULATION; NERVE CONDUCTION; NONHUMAN; PAIN; PRIORITY JOURNAL; SPINAL CORD DORSAL HORN;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; BICUCULLINE; BLOOD PRESSURE; CATS; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLYCINE AGENTS; MICRODIALYSIS; NEURALGIA; NEURONS, AFFERENT; NOCICEPTORS; PAIN THRESHOLD; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; STIMULATION, CHEMICAL; STRYCHNINE;

EID: 0031669246     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00094-3     Document Type: Article

References (38)

1. Alvarez, F.J., Kavookjian, A.M. and Light, A.R., Synaptic interactions between GABA-immunoreactive profiles and the terminals of functionally defined myelinated nociceptors in the monkey and cat spinal cord, J. Neurosci., 12 (1992) 2901-2917.
2. Barber, R.P., Vaughn, J.E., Saito, K., McLaughlin, B.J. and Roberts, E., GABAergic terminals are presynaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord, Brain Res., 141 (1978) 35-55.
3. Bernardi, P.S., Valtschanoff, J.G., Weinberg, R.J., Schmidt, H.H. and Rustioni, A., Synaptic interactions between primary afferent terminals and GABA and nitric oxide-synthesizing neurons in superficial laminae of the rat spinal cord, J. Neurosci., 15 (1995) 1363-1371.
4. Birch, P., Grossman, C. and Hayes, A., 6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7 cyano-quinoxaline-2,3-dion antagonize responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor, Eur. J. Pharmacol., 156 (1988) 177-180.
5. Campbell, J.N., Raja, S.N., Meyer, R.A. and Mackinnon, S.E., Myelinated afferents signal the hyperalgesia associated with nerve injury, Pain, 32 (1988) 89-94.
6. Carlton, S.M. and Hayes, E.S., Light microscopic and ultrastructural analysis of GABA immunoreactive profiles in the monkey spinal cord, J. Comp. Neurol., 300 (1990) 162-182.
7. Carlton, S.M., Westlund, K.N., Zhang, D. and Willis, W.D., GABA-immunoreactive terminals synapse on primate spinothalamic tract cells, J. Comp. Neural., 322 (1992) 528-537.
8. Castro-Lopes, J.M., Tavares, I. and Coimbra, A., GABA decreases in the spinal cord dorsal horn after peripheral neurectomy, Brain Res., 620 (1993) 287-291.
9. Chung, J.M., Surmeier, D.J., Lee, K.H., Sorkin, L.S., Honda, C.N., Tsong, Y. and Willis, W.D., Classification of primate spinothalamic and somatosensory thalamic neurons based on cluster analysis, J. Neurophysiol., 56 (1986) 308-327.
10. Dougherty, P.M., Palecek, J., Paleckova, V., Sorkin, L.S. and Willis, W.D., The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal and electrical stimuli, J. Neurosci., 12 (1992) 3025-3041.
11. Duggan, A.W., Griersmith, B.T. and Johnson, S.M., Supraspinal inhibition of the excitation of dorsal horn neurones by impulses in unmyelinated primary afferents lack of effect by strychnine and bicuculline, Brain Res., 210 (1981) 231-241.
12. Hammond, D.L. and Drower, E.J., Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold, Eur. J. Pharmacol., 103 (1984) 121-125.
13. Hao, J.X., Xu, X.J., Yu, X.Y., Seiger, A. and Wiesenfeld-Hallin, Z., Baclofen reverses the hypersensitivity of dorsal horn wide dynamic range neurons to mechanical stimulation after transient spinal cord ischemia; implications for a tonic GABAergic inhibitory control of myelinated fiber input, J. Neurophysiol., 68 (1992) 392-396.
14. Koltzenburg, M., Torebjork, H.E. and Wahren, L.K., Nociceptor modulated centre sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain, Brain, 117 (1994) 579-591.
15. A antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray, Brain Res., 654 (1994) 286-302.
16. Lin, Q., Peng, Y.B. and Willis, W.D., Role of GABA receptor subtypes in inhibition of primate spinothalamic tract neurons: differences between spinal and periaqueductal gray inhibition, J. Neurophys., 75 (1996) 109-123.
17. Maxwell, D.J., Todd, A.J. and Kerr, R., Colocalization of glycine and GABA in synapses on spinomedullary neurons, Brain Res., 690 (1995) 127-132.
18. Millhorn, D.E., Hokfelt, T., Seroogy, K., Oertel, W., Verhofstad, A.A. and Wu, J.Y., Immunocytochemical evidence for colocalization of gamma-aminobutyric acid and serotonin in neurons of the ventral medulla oblongata projecting to the spinal cord, Brain Res., 410 (1987) 179-185.
19. Onaka, M., Minami, T., Nishihara, I. and Ito, S., Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice, Anesthesiology, 84 (1996) 1215-1222.
20. Persohn, E., Malherbe, P. and Richards, J.G., In situ hybridization histochemistry reveals a diversity of GABAA receptor subunit mRNAs in neurons of the rat spinal cord and dorsal root ganglia, Neurosci., 42 (1991) 497-507.
21. Roberts, L.A., Beyer, C. and Komisaruk, B.R., Nociceptive responses to altered GABAergic activity at the spinal cord, Life Sci., 39 (1986) 1667-1674.
22. Schaible, H.G., Neugebauer, V., Cervero, F. and Schmidt, R.F., Changes in tonic descending inhibition of spinal neurons with articular input during the development of acute arthritis in the cat, J. Neurophysiol., 66 (1991) 1021-1032.
23. 3H]muscimol binding sites in rat dorsal spine cord after neonatal capsaicin treatment, Brain Res., 202 (1980) 484-487.
24. Sivilotti, L. and Woolf, C.J., The contribution of GABAA and glycine receptors to centre sensitization: disinhibition and touch-evoked allodynia in the spinal cord, J. Neurophysiol., 72 (1994) 169-179.
25. B receptor antagonist in rats., J. Pharmacol. Exp. Ther., 271 (1994) 76-82.
26. Sorkin, L.S., McAdoo, D.J. and Willis, W.D., Raphe magnus stimulation-induced antinociception in the cat is associated with release of amino acids as well as serotonin in the lumbar dorsal horn, Brain Res., 618 (1993) 95-108.
27. Sorkin, L.S. and Puig, S., Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a μ-opiate receptor agonist, Pain, 68 (1996) 283-292.
28. Sorkin, L.S., Steinman, J.L., Hughes, M.G., Willis, W.D. and McAdoo, D.J., Microdialysis recovery of serotonin released in spinal cord dorsal horn, J. Neurosci. Methods, 23 (1988) 131-138.
29. Todd, A.J. and Lochhead, V., GABA-like immunoreactivity in type I glomeruli of rat substantia gelatinosa, Brain Res., 514 (1990) 171-174.
30. Todd, A.J., Spike, R.C., Brodbelt, A.R., Price, R.F. and Shehab, S.A., Some inhibitory neurons in the spinal cord develop c-fos-immunoreactivity after noxious stimulation, Neuroscience, 63 (1994) 805-816.
31. Todd, A.J. and Sullivan, A.C., Light microscope study of the co-existence of GABA-like and glycine-like immunoreactivity in the spinal cord of the rat, J. Comp. Neurol., 296 (1990) 496-505.
32. Willcockson, W.S., Chung, J.M., Hori, Y., Lee, K.H. and Willis, W.D., Effects of iontophoretically released amino acids and amines on primate spinothalamic tract cells, J. Neurosci., 4 (1984) 732-740.
33. Willis, W.D., Haber, L.H. and Martin, R.F., Inhibition of spinothalamic tract cells and interneurons by brain stem stimulation in the monkey, J. Neurophysiol., 40 (1977) 968-981.
34. Wilson, P.R. and Yaksh, T.L., Baclofen is antinociceptive in the spinal intrathecal space of animals, Eur. J. Pharmacol., 51 (1978) 323-330.
35. Yaksh, T.L., Behavioral and autonomie correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists, Pain, 37 (1989) 111-123.
36. Yaksh, T.L. and Reddy, S.V., Studies in the primate on the analgesic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen, Anesthesiology, 54 (1981) 451-467.
37. Yamamoto, T. and Yaksh, T.L., Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801, Pain, 54 (1993) 79-84.
38. Zhang, A.-L., Hao, J.-X., Seiger, A. and Wiesenfeld-Hallin, Z., Decreased GABA immunoreactivity in spinal cord dorsal horn after transient spinal cord ischemia in the rat, Brain Res., 656 (1994) 187-190.