Amino acid residues affecting the activities of human cytochrome P450 2C9 and 2C19

Drug Metabolism and Disposition

Volumn 30, Issue 8, 2002, Pages 931-936

  Niwa, Toshiro ^a,b,c   Kageyama, Akira ^a,b,c   Kishimoto, Kae ^a,b,c   Yabusaki, Yoshiyasu ^a,b,c   Ishibashi, Fumihide ^a,b,c   Katagiri, Masanao ^a,b,c  

^a OSAKA KYOIKU UNIVERSITY   (Japan)

^b SUMITOMO CHEMICAL CO LTD   (Japan)

^c ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMINOPHENAZONE; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; DICLOFENAC; HISTIDINE; MEPHENYTOIN; OXYGENASE; TESTOSTERONE; TOLBUTAMIDE;

ARTICLE; BINDING SITE; CHIMERA; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HYDROXYLATION; MICHAELIS CONSTANT; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; AMINOPYRINE; ARYL HYDROCARBON HYDROXYLASES; DICLOFENAC; HUMANS; KINETICS; MEPHENYTOIN; MICROSOMES; MIXED FUNCTION OXYGENASES; POINT MUTATION; RECOMBINANT FUSION PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TESTOSTERONE; TOLBUTAMIDE;

EID: 0036320581     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.8.931     Document Type: Article

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