Inhibition of human hepatic cytochrome P450s and steroidogenic CYP17 by nonylphenol

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 2, 2002, Pages 235-238

  Niwa, Toshiro ^a,c   Maekawa, Yumi ^a   Fujimoto, Megumi ^a   Kishimoto, Kae ^b   Yabusaki, Yoshiyasu ^b   Ishibashi, Fumihide ^a   Katagiri, Masanao ^a  

^a OSAKA KYOIKU UNIVERSITY   (Japan)

^b SUMITOMO CHEMICAL CO LTD   (Japan)

^c Fujikawa Pharmaceutical Co Ltd   (Japan)

Author keywords

Aminopyrine N demethylation; CYP17; Human hepatic cytochrome P450; Nonylphenol; Progesterone 17 hydroxylation

Indexed keywords

4' HYDROXYMEPHENYTOIN; AMINOPYRINE N DEMETHYLASE; CYTOCHROME P450; CYTOCHROME P450 17; CYTOCHROME P450 1A2; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; DICLOFENAC; NONYLPHENOL; UNCLASSIFIED DRUG; AMINOPHENAZONE; CYP1A2 PROTEIN, HUMAN; CYP2C19 PROTEIN, HUMAN; CYP2C8 PROTEIN, HUMAN; CYP2C9 PROTEIN, HUMAN; MIXED FUNCTION OXIDASE; PHENOL DERIVATIVE; STEROID 16ALPHA MONOOXYGENASE; STEROID 17ALPHA MONOOXYGENASE; STEROID MONOOXYGENASE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; NONHUMAN; DOSE RESPONSE; DRUG ANTAGONISM; ENZYMOLOGY; LIVER; METABOLISM;

AMINOPYRINE; AMINOPYRINE N-DEMETHYLASE; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIVER; MIXED FUNCTION OXYGENASES; PHENOLS; STEROID 16-ALPHA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

EID: 0036482979     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.235     Document Type: Article

References (23)

1. Ridway T. J., Wiseman H., Biochem. Soc. Trans., 26, 675-680 (1998).
2. Soto A. M., Justica H., Wray J. W., Sonnenschien C., Environ. Health Perspect., 92, 167-173 (1991).
3. Giger W., Brunner P. H., Schaffner C., Science, 225, 623-625 (1984).
4. Guengerich F. P., FASEB J., 6, 745-748 (1992).
5. Gonzalez F. J., Pharmacol. Ther., 45, 1-38 (1990).
6. Niwa T., Yabusaki Y., Homma K., Matsuo N., Tatsuta K., Ishibashi F., Katagiri M., Xenobiotica, 28, 539-547 (1998).
7. Lee P. C., Marquardt M. Lech J. J., Toxicol. Lett., 99, 117-126 (1998).
8. Lee P. C., Chakraborty Patra S., Struve M., Xenobiotica, 26, 831-838 (1996).
9. Lee P. C., Chakraborty Patra S., Stelloh C. T., Lee W., Struve M., Biochem. Pharmacol. 52, 885-889 (1996).
10. Kagawa N., Waterman M. R., "Cytochrome P450: Structure, Mechanism, and Biochemistry," 2nd ed., ed. by Ortiz de Montellano P. R., Plenum, New York, 1995, pp. 419-442.
11. Guengerich F. P., J. Pharmacokin. Biopharm., 24, 521-533 (1996).
12. Aoyama T., Korzekwa K., Nagata K., Gillette J., Gelboin H. V., Gonzales F. J., Endocrinology, 126, 3101-3106 (1990).
13. Imaoka S., Terano Y., Funae Y., J. Biochem., 105, 939-945 (1989).
14. Niwa T., Sato R., Yabusaki Y., Ishibashi F., Katagiri M., Xenobiotica, 29, 187-193 (1999).
15. Niwa T., Tsutsui M., Kishimoto K., Yabusaki Y., Ishibashi F., Katagiri M.; Biol. Pharm. Bull., 23, 498-501 (2000).
16. Niwa T., Fujimoto M., Kishimoto K., Yabusaki Y, Ishibashi F., Katagiri M., Biol. Pharm. Bull., 24, 1064-1067 (2001).
17. Imaoka S., Yamada T., Hiroi T., Hayashi K., Sakaki T., Yabusaki Y., Funae Y., Biochem. Pharmacol., 51, 1041-1050 (1996).
18. Katagiri M., Kagawa N., Waterman M. R., Arch. Biochem. Biophys., 17, 343-347 (1995).
19. Omura T., Sato R., J. Biol. Chem., 239, 2379-2385 (1964).
20. Nash T., Biochem. J., 55, 416-421 (1953).
21. Leemann T., Transon C., Dayer P., Life Sci., 52, 29-34 (1992).
22. Bort R., Mace K., Boobis A., Gomez-Lechon M., Pfeifer A., Castell J., Biochem, Pharmacol., 58, 787-796 (1999).
23. Clarke S. E., Xenobiotica, 28, 1167-1202 (1998).