IFN-γ-independent synergistic effects of IL-12 and IL-15 induce anti-tumor immune responses in syngeneic mice

European Journal of Immunology

Volumn 32, Issue 7, 2002, Pages 1914-1923

  Comes, Alberto ^a   Di Carlo, Emma ^b   Musiani, Piero ^b   Rosso, Ombretta ^a   Meazza, Raffaella ^a,c   Chiodoni, Claudia ^d   Colombo, Mario P ^d   Ferrini, Silvano ^a,e  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF INSUBRIA   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Gene transfer; IFN knockout; IL 12; IL 15; Tumor immunity

Indexed keywords

CD8 ANTIGEN; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CARCINOGENICITY; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG POTENTIATION; FEMALE; GENETIC ENGINEERING; GRANULOCYTE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; T LYMPHOCYTE; TUMOR CELL; TUMOR IMMUNITY; TUMOR REJECTION; WILD TYPE;

ADENOCARCINOMA; ANIMALS; BREAST NEOPLASMS; CARCINOGENICITY TESTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; FEMALE; GRANULOCYTES; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-15; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036316062     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200207)32:7<1914::AID-IMMU1914>3.0.CO;2-P     Document Type: Article

References (39)

1. Cytokine gene transduction in the immunotherapy of cancer
2. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
3. Interleukin 15: Biology and relevance to human disease
4. Reversible defects in Natural Killer and Memory CD8 T cell lineages in interleukin-15-deficient mice
5. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
6. Is IL-15 a suitable candidate for cancer gene therapy?
7. Expression of two interleukin-15 mRNA isoforms in human tumors does not correlate with secretion, role of different signal peptides
8. The 5′ untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control
9. Differential intracellular traffing, secretion and endosomal localization of two IL-15 isoforms
10. Immunogene therapy for murine fibrosarcoma using IL-15 gene with high translational efficiency
11. Gene transfer of a secretable form of IL-15 in murine adenocarcinoma cells: Effects on tumorigenicity, metastatic potential, and immune response
12. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
13. Interleukin-12. Biologic activity, therapeutic utility, and role in disease
14. Interleukin-12 mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice
15. Antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines compared with exogenous IL-12
16. Long-lasting anti-metastic efficiency of IL-12-encoding plasmid DNA
17. Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12
18. Human interferon-inducible protein 10 is a potent inducer of angiogenesis in vivo
19. IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk
20. Role of IFN-γ in mediating the antitumor efficacy of IL-12
21. Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: Implications for the innate immune response
22. IL-12 gene therapy for cancer: In synergy with other immunotherapies
23. Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a malignant pleurisy model
24. The combined action of IL-15 and IL-12 gene transfer can induce tumor cell rejection without T and NK cell involvement
25. Multiple defects of immune cell function in mice with disrupted interferon-γ genes
26. + T cells and granulocyte/macrophage colony-stimulating factor
27. IL-15 is chemotactic for natural killer cells and stimulates their adhesion to vascular endothelium
28. Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): Analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin
29. Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis
30. In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection
31. Interleukin-12 is chemotactic for natural killer cells and stimulates their interaction with vascular endothelium
32. Leukocyte-endothelial adhesion molecules
33. Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways
34. 2+ and tyrosine signaling pathways in human neutrophilis
35. Interleukin-15 (IL-15) induces NF-κB activation and IL-8 production in human neutrophilis
36. Neutrophil-mediated damage to human vascular endothelium. Role of cytokine activation
37. Cytokine-induced neutrophil-mediated injury of human endothelial cells
38. TS/A: A new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma
39. Murine dendritic cell loaded in vitro with soluble protein prime CTL against tumor antigen in vitro