IL-12 gene therapy for cancer: In synergy with other immunotherapies

Trends in Immunology

Volumn 22, Issue 3, 2001, Pages 113-115

  Melero, Ignacio ^a   Mazzolini, Guillermo ^a   Narvaiza, Iñigo ^a   Qian, Cheng ^a   Chen, Lieping ^b   Prieto, Jesús ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; INTERLEUKIN 12; MEMBRANE PROTEIN;

ANTINEOPLASTIC ACTIVITY; CANCER; CELLULAR IMMUNITY; DRUG POTENTIATION; EFFECTOR CELL; GENE THERAPY; GENE TRANSFER; GENETIC CODE; IMMUNOTHERAPY; NONHUMAN; SHORT SURVEY;

EID: 0034918717     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(00)01824-X     Document Type: Review

References (16)

1. Interleukin-12: A cytokine at the interface of inflammation and immunity
2. Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12
3. Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10
4. Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for IL-12
5. Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors
6. The combined action of IL-15 and IL-12 gene transfer can induce tumor cell rejection without T and NK cell involvement
7. Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18)
8. Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models
9. Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy
10. Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors
11. Gene transfer to liver cancer cells of B7-1 plus interleukin 12 changes immunoeffector mechanisms and suppresses helper T cell type 1 cytokine production induced by interleukin 12 alone
12. Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: Long-term remission of liver metastases in a mouse model
13. Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation
14. Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level
15. Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas
16. Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12