Antifolate trimetrexate: Observation of the enzyme-binding conformation

Acta Crystallographica, Section C: Crystal Structure Communications

Volumn 56, Issue 10, 2000, Pages 1225-1227

  Hempel, Andrew ^a   Camerman, Norman ^a   Mastropaolo, Donald ^b   Camerman, Arthur ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b Ardono Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; ENZYMES; HYDROGEN BONDS; WATER;

DIHYDROFOLATE REDUCTASE (DHFR);

CRYSTALLINE MATERIALS;

EID: 0034293783     PISSN: 01082701     EISSN: None     Source Type: Journal    
DOI: 10.1107/S0108270100008349     Document Type: Article

References (11)

1. Bolin, J. T., Filman, D. J., Matthews, D. A., Hamlin, R. C. & Kraut, J. (1982). J. Biol. Chem. 257, 13650-13662.
2. Farrugia, L. J. (1997). J. Appl. Cryst. 30, 565.
3. Gargaro, A. R., Soteriou, A., Frenkiel, T. A., Bauer, C. J., Birdsall, B., Polshakov, V. I., Barsukov, I. L., Roberts, G. C. & Feeney, J. (1998). J. Mol. Biol. 277, 119-134.
4. Hempel, A., Camerman, N. & Camerman, A. (1988). Cancer Biochem. Biophys. 10, 25-30.
5. Hoffman, V. A. & Welsh, W. J. (1995). Cancer Biochem. Biophys. 14, 281-295.
6. Mastropaolo, D., Smith, H. W., Camerman, A. & Camerman, N. (1986). J. Med. Chem. 29, 155-158.
7. Nonius (1997). KappaCCD Server Software. Nonius BV, Delft, The Netherlands.
8. Otwinowski, Z. & Minor, W. (1997). Methods Enzymol. 276, 307-326.
9. Polshakov, V. I., Birdsall, B., Frenkiel, T. A., Gargaro, A. R. & Feeney, J. (1999). Protein Sci. 8, 467-481.
10. Sheldrick, G. M. (1997). SHELXS97 and SHELXL97. University of Göttingen, Germany.
11. Sutton, P. A. & Cody, V. (1987). J. Med. Chem. 30, 1843-1848.