Down-regulation of survivin expression in T lymphocytes after interferon beta-1a treatment in patients with multiple sclerosis

Archives of Neurology

Volumn 59, Issue 7, 2002, Pages 1115-1121

  Sharief, Moad K ^a   Semra, Yemane K ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1A INTERFERON; FAS ANTIGEN; MITOGENIC AGENT; PROTEIN BCL 2; SURVIVIN;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; DOWN REGULATION; HUMAN; HUMAN CELL; LONG TERM CARE; MULTIPLE SCLEROSIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ADULT; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; DOWN-REGULATION; FEMALE; HUMANS; INTERFERON-BETA; LONGITUDINAL STUDIES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MULTIPLE SCLEROSIS; NEOPLASM PROTEINS; PROSPECTIVE STUDIES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTES;

EID: 0036310991     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.59.7.1115     Document Type: Article

References (57)

1. The central effectors of cell death in the immune system
2. Apoptotic and effector pathways in autoimmunity
3. Fas(t) track to apoptosis in MS: TNF receptors may suppress or potentiate CNS demyelination
4. CD95's deadly mission in the immune system
5. Impaired apoptosis in mitogen-stimulated lymphocytes of patients with multiple sclerosis
6. Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis
7. Impaired apoptotic deletion of myelin basic protein-reactive T cells in patients with multiple sclerosis
8. Neuroprotection by the inhibition of apoptosis
9. Defective T cell Fas function in patients with multiple sclerosis
10. Apoptosis mediators FasL and TRAIL are upregulated in peripheral blood mononuclear cells in MS
11. Increased Fas antigen on T cells in multiple sclerosis
12. Impaired Fas-independent apoptosis of T lymphocytes in patients with multiple sclerosis
13. Serum CD95 of relapsing remitting MS patients protects from CD95-mediated apoptosis
14. Interferon beta in the treatment of multiple sclerosis: Mechanisms of action
15. Interferon-beta 1b augments activation-induced T-cell death in multiple sclerosis patients
16. Interferon-beta therapy downregulates the anti-apoptosis protein FLIP in T cells from patients with multiple sclerosis
17. No induction of apoptosis by IFN-beta in human antigen-specific T cells
18. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
19. The most unkindest cut of all: On the multiple roles of mammalian caspases
20. BIRinging chromosomes through cell division-and survivin' the experience
21. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
22. The survivin saga goes in vivo
23. Survivin apoptosis: An interloper between cell death and cell proliferation in cancer
24. Expression of survivin mRNA in CD34-positive cells
25. Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34+ cells by hematopoietic growth factors: Implication of survivin expression in normal hematopoiesis
26. Survivin expression correlates with apoptosis resistance after lymphocyte activation and is found preferentially in memory T cells
27. Heightened expression of survivin in activated T lymphocytes from patients with multiple sclerosis
28. Disease activity in multiple sclerosis correlates with T lymphocyte expression of the inhibitor of apoptosis proteins
29. Upregulation of the inhibitor of apoptosis (IAP) proteins in activated T lymphocytes from patients with multiple sclerosis
30. Cross-linking of the Fas/APO-1 antigen suppresses the CD3-mediated signal transduction events in human T lymphocytes
31. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
32. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
33. Control of apoptosis during angiogenesis by survivin expression in endothelial cells
34. Therapy of relapsing multiple sclerosis: Treatment approaches for nonresponders
35. Does high-dose interferon beta-1b improve clinical response in more severely disabled multiple sclerosis patients?
36. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway
37. The role of interferon regulatory factors in the interferon system and cell growth control
38. Antineoplastic effect of interferon beta is associated with apoptosis pathway in human colon adenocarcinoma cell line
39. Interferon alpha augments activation-induced T cell death by upregulation of Fas (CD95/APO-1) and Fas ligand expression
40. Control of apoptosis and mitotic spindle checkpoint by survivin
41. Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast
42. Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance
43. Apoptosis in multiple sclerosis
44. Interferon-beta interferes with the proliferation but not with the cytokine secretion of myelin basic protein-specific, T-helper type 1 lymphocytes
45. Interferon (IFN)-beta treatment enhances CD95 and interleukin 10 expression but reduces interferon-gamma producing T cells in MS patients
46. Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins
47. The interferon-beta and tamoxifen combination induces apoptosis using thioredoxin reductase
48. Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs
49. Survivin' cell-separation anxiety
50. Expression of the novel inhibitor of apoptosis survivin in normal and neoplastic skin
51. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
52. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
53. De-novo humoral immune responses to cancer-associated autoantigens during transition from chronic liver disease to hepatocellular carcinoma
54. Fas/APO-1 (CD95)-mediated apoptosis is activated by interferon-gamma and interferon-alpha in interleukin-6 (IL-6)-dependent and IL-6-independent multiple myeloma cell lines
55. Analysis of the role of bcl-2 in apoptosis
56. Apoptosis and proliferation (PCNA labelling) in CML - A comparative immunohistological study on bone marrow biopsies following interferon and busulfan therapy
57. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling