Impaired apoptotic deletion of myelin basic protein-reactive T cells in patients with multiple sclerosis

European Journal of Immunology

Volumn 29, Issue 5, 1999, Pages 1692-1700

  Zang, Ying C Q ^b   Kozovska, Milena M ^b   Hong, Jian ^b   Li, Sufang ^b   Mann, Savita ^b   Killian, James M ^b   Rivera, Victor M ^b   Zhang, Jingwu Z ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

Apoptosis; Autoimmunity; Multiple sclerosis; Myelin basic protein; T cell

Indexed keywords

ANTIBODY; FAS LIGAND; MYELIN BASIC PROTEIN;

ADULT; APOPTOSIS; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; MALE; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; CELL LINE; CYTOKINES; FAS LIGAND PROTEIN; HUMANS; MEMBRANE GLYCOPROTEINS; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; T-LYMPHOCYTES;

EID: 0032904234     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199905)29:05<1692::AID-IMMU1692>3.0.CO;2-H     Document Type: Article

References (23)

1. Stinissen, P., Raus, J. and Zhang, J., Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies. Crit. Rev. Immunol. 1997. 17: 33-75.
2. Zamvil, S., Nelson, P., Trotter, J., Mitchell, D. J., Knobler, R., Fritz, R. and Steinman, L., T cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature 1985. 317: 355-358.
3. Zhang, J., Medaer, R., Hashim, G., Ying, C., van den Berg-Loonen, E. and Raus, J., Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity. Ann. Neurol. 1992. 32: 330-338.
4. Ota, K., Matsui, M., Milford, E. L., Mackin, G. A., Weiner, H. L. and Hafler, D. A., T cell recognition of an immunodominant MBP epitope in multiple sclerosis. Nature 1990. 346: 183-187.
5. Pette, M., Fujita, K., Wilkinson, D., Altmann, D. M., Trowsdale, J., Giegerich, G., Hinkkanen, A., Epplen, J. T. and Kappos, L., Myelin autoreactivity in multiple sclerosis: recognition of MBP in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA 1990. 87: 7968-7972.
6. Martin, R., Howell, M. D., Jaraquemada, D., Richert, J. R., Flerlage, M., Robinson, E., Stone, R., Riddison, W. E., McFarlin, D. E. and McFarland H. F., A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J. Exp. Med. 1991. 173: 19-24.
7. Bieganowska, K. D., Ausubel, L. J., Modabber, Y., Slovik, E., Messermith, W. and Hafler, D. A., Direct ex vivo analysis of activated Fas-sensitive autoreactive T cells in human autoimmune disease. J. Exp. Med. 1997. 185: 1585-1594.
8. Allegretta, M., Nicklas, J. A., Sriam, S. and Albertini, R. J., T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990. 247: 718-721.
9. Zhang, J., Markovic, S., Lacet, B., Raus, J., Weiner, H. L. and Hafler, D. A., Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 1994. 179: 973-984.
10. Chou, Y. K., Bourdette, D. N., Offner, H. and Vandenbark, A. A., Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J. Neuroimmunol. 1992. 38: 105-113.
11. Miller, J. F., Morahan, G., Slattery, R. and Allison, J., Transgenic models of T-cell self tolerance and autoimmunity. Immunol. Rev. 1990. 118: 21-35.
12. Poser, C. M., New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 1983. 13: 227-231.
13. Zhang, J., Medaer, R., Stinissen, P., Hafler, D. A. and Raus, J., MHC restricted clonotypic depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 1993. 261: 1451-1454.
14. Zipp, F., Martin, R., Lichtenfels, R., Roth, W., Dichgans, J., Krammer, P. H. and Weller, M., Human autoreactive and foreign antigen-specific T cells resist apoptosis induced by soluble recombinant CD95 ligand. J. Immunol. 1997. 159: 2108-2115.
15. Lenardo, M. J., Fas and the art of lymphocyte maintenance. J. Exp. Med. 1996. 183: 721-724.
16. Tamura, A., Katsumata, M., Greene, M. I. and Yui, K., Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice. Cell. Immunol. 1996. 168: 220-228.
17. Lenardo, M. J., Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 1991. 353: 858-861.
18. Pelfrey, C. M., Tranquill, L. R., Boehme, S. A., McFarland, H. F. and Lenardo, M. J., Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from patients with multiple sclerosis and normal individuals. J. Immunol. 1995. 154: 6191-6202.
19. Zavazava, N. and Kronke, M., Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nat. Med. 1996. 2: 1005-1010.
20. + T cell apoptosis. J. Immunol. 1997. 158: 2456-2463.
21. McCutcheon, M., Wehner, N., Wensky, A., Kushner, M., Hsiao, L., Calabresi, P., Ha, T., Tran, T. V., Tate, K. M., Winkehake, J. and Spack, E. G., A sensitive ELISPOT assay to detect low-frequency human T lymphocytes. J. Immunol. Methods 1997. 210: 149-166.
22. Deibler, G. E., Martenson, R. E. and Kies, M. W., Large scale preparation of myelin basic protein of several mammalian species. Prep. Biochem. 1972. 2: 139-165.
23. Hermans, G., Mertens, N., Hauben, L., Stinissen, P., Raus, J. and Zhang, J., The cytokine profile of MBP-reactive T cells and early lines in multiple sclerosis and healthy controls. Ann. Neurol. 1997. 42: 18-27.