Overnight normalization of glucose concentrations improves hepatic but not extrahepatic insulin action in subjects with type 2 diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 7, 1998, Pages 2461-2469

  Wise, Steven D ^a   Nielsen, Michael F ^a   Cryer, Philip E ^b   Rizza, R A ^a  

^a MAYO CLINIC   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C PEPTIDE; FATTY ACID; GLUCAGON; GLUCOSE; GROWTH HORMONE; INSULIN; ISOPHANE INSULIN; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FEMALE; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GROWTH HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN INFUSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; LIVER METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; EPINEPHRINE; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCAGON; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LIVER; MALE; NOREPINEPHRINE; OXIDATION-REDUCTION;

EID: 0031728154     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.7.2461     Document Type: Article

References (70)

1. Fanelli C, Pampanelli S, Calderone S, et al. 1995 Effects of recent, short-term hyperglycmia on response to hypoglycemia in humans. Relevance to the pathogenesis of hypoglycemia unawareness and hyperglycemia-induced insulin resistance. Diabetes. 44:513-519.
2. Yki-Jarvinen H, Helve E, Koivisto VA. 1987 Hyperglycemia decreases glucose uptake in type I diabetes. Diabetes. 36:892-896.
3. Lisato G, Cusin I, Tiengo A, Del Prato S, Jeanrenaud B. 1992 The contribution of hyperglycemia and hypoinsulinemia to the insulin resistance of streptozotocin-diabetic rats. Diabetologia. 35:310-315.
4. Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. 1987 Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin indiabetic rats. J Clin Invest. 79:1510-1515.
5. Dimitrakoudis D, Vranic M, Klip A. 1992 Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia. J Am Soc Nephrol. 3:1078-1091.
6. Scarlett JA, Kolterman OG, Ciaraldi TP, Kao M, Olefsky JM. 1983 Insulin treatment reverses the postreceptor defect in adipocyte 3-O-methylglucose transport in type II diabetes mellitus. J Clin Endocrinol Metab. 56:1195-1201.
7. Firth RG, Bell PM, Rizza RA. 1986 Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus. N Engl J Med. 314:1280-1286.
8. Scarlett JA, Gray RS, Griffin J, Olefsky JM, Kolterman OG. 1982 Insulin treatment reverses the insulin resistance of type II diabetes mellitus. Diabetes Care. 5:353-363.
9. Foley JE, Kashiwagi A, Verso MA, Reaven G, Andrews J. 1983 Improvement in in vitro insulin action after one month of insulin therapy in obese noninsulin-dependent diabetics. J Clin Invest. 72:1901-1909.
10. Fasching P, Ratheiser K, Damjancic P, et al. 1993 Both acute and chronic near-normoglycaemia are required to improve insulin resistance in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 36:346-351.
11. Zierath JR, Galuska D, Nolte LA, et al. 1994 Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: in vitro reversal of muscular insulin resistance. Diabetologia. 37:270-277.
12. Finegood DT, Bergman RN, Vranic M. 1988 Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes. 37:1025-1034.
13. Levy JC, Brown DR, Turner RC. 1989 Hepatic glucose output in humans measured with labeled glucose to reduce negative errors. Am J Physiol.:E531-E540.
14. Butler PC, Caumo A, Zerman A, O'Brien PC, Cobelli C, Rizza RA. 1993 Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans. Am J Physiol. 264:E548-E69.
15. Kolterman OG, Gray RS, Griffin J, et al. 1981 Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest. 68:957-969.
16. Bogardus C, Lillioja S, Howard BV, Reaven G, Mott D. 1984 Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clin Invest. 74:1238-1246.
17. DeFronzo RA, Simonson D, Ferrannini E. 1982 Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 23:313-319.
18. Firth R, Bell P, Rizza R. 1987 Insulin action in non-insulin-dependent diabetes mellitus: the relationship between hepatic and extrahepatic insulin resistance and obesity. Metabolism. 36:1091-1095.
19. Bonadonna RC, Del Prato S, Saccomani MP, et al. 1993 Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes. J Clin Invest. 92:486-494.
20. Baron AD, Laakso M, Brechtel G, Edelman SV. 1991 Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. J Clin Invest. 87:1186-1194.
21. Golay A, DeFronzo RA, Ferrannini E, et al. 1988 Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 31:585-591.
22. 13C nuclear magnetic resonance spectroscopy. N Engl J Med. 322:223-228.
23. Vaag A, Alford F, Henriksen FL, Christopher M, Beck-Nielsen H. 1995 Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM. Diabetologia. 38:326-336.
24. Damsbo P, Vaag A, Hother-Nielsen O, Beck-Nielsen H. 1991 Reduced glycogen synthase activity in skeletal muscle fromobese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 34:239-245.
25. Kelley DE, Mokan M, Mandarine LJ. 1993 Metabolic pathways of glucose in skeletal muscle of lean NIDDM patients. Diabetes Care. 16:1158-1166.
26. Ortmeyer HK, Bokdin NL, Hansen BC. 1994 Relationship of skeletal muscle glucose 6-phosphate to glucose disposal rate and glycogen synthase activity ininsulin-resistant and non-insulin-dependent diabetic rhesus monkeys. Diabetologia. 37:127-133.
27. Kelley DE, Mokan M, Mandarino LJ. 1992 Intracellular defects in glucose metabolism in obese patients with NIDDM. Diabetes. 41:698-706.
28. Turk D, Alzaid A, Dinneen S, Nair KS, Rizza R. 1995 The effects of noninsulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues. J Clin Invest. 95:755-762.
29. Alzaid AA, Dinneen SF, Turk DJ, Caumo A, Cobelli C, Rizza RA. 1994 Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans. J Clin Invest. 94:2341-2348.
30. Basu A, Alzaid A, Dinneen S, Caumo A, Cobelli C, Rizza RA. 1996 Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance. J Clin Invest. 97:2351-2361.
31. Shank ML, Del Prato S, DeFronzo RA. 1995 Bedtime insulin/daytime glipizide. Diabetes. 44:165-172.
32. Yki-Jarvinen H, Kauppila M, Kujansuu E. 1992 Comparison of insulin regimens in patients with non-insulin-dependent diabetes mellitus. N Engl J Med. 327:1426-1433.
33. Cusi K, Cunningham GR, Comstock JP. 1995 Safety and efficacy of normalizing fasting glucose with bedtime NPH insulin alone in NIDDM. Diabetes Care. 18:843-851.
34. Marshall S, Olefsky JM. 1980 Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. J Clin Invest. 66:763-772.
35. Marangou AG, Weber KM, Boston RC, et al. 1986 Metabolic consequences of prolonged hyperinsulinemia in humans. Evidence for induction of insulin insensitivity. Diabetes. 35:1383-1389.
36. Nankervis A, Proietto J, Aitken P, Alford F. 1985 Hyperinsulinaemia and insulin insenstivity: studies in subjects with insulinoma. Diabetologia. 28:427-531.
37. Rizza RA, Mandarino LJ, Genest J, Baker BA, Gerich JE. 1985 Production of insulin resistance by hyperinsulinaemia in man. Diabetologia. 28:70-75.
38. White NH, Skor D, Santiago JV. 1982 Practical closed-loop insulin delivery. A system for the maintenance of overnight euglycemia and the calculation of basal insulin requirements in insulin-dependent diabetics. Ann Intern Med. 97:210-213.
39. Rizza RA, Mandarino LJ, Gerich JE. 1981 Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol. 240:E630-E639.
40. McMahon M, Marsh HM, Rizza RA. 1989 Effects of basal insulin supplementation on disposition of mixed meal in obese patients with NIDDM. Diabetes. 38:291-303.
41. Frayn KN. 1983 Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol. 55:628-634.
42. Pehling G, Tessari P, Gerich JE, Haymond MW, Service FJ, Rizza RA. 1984 Abnormal meal carbohydrate disposition in insulin-dependent diabetes. J Clin Invest. 74:985-991.
43. Bradley DC, Steil GM, Bergman RN. 1993 Quantitation of measurement error with optimal segments: basis for adaptive time course smoothing. Am J Physiol. 264:E902-E911.
44. Steele R, Wall JS, De Bodo RC, Altszuler N, Kiang SP, Bjerknes C. 1956 Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol. 187:15-24.
45. 14C labeled substrates. Am J Physiol. 17:391-399.
46. 2 in estimating rates of hepatic gluconeogenesis. Am J Physiol. 263:E36-E41.
47. Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA. 1994 Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia. 37:1925-1935.
48. Vuorinen-Markkola H, Koivisto VA, Yki-Jarvinen H. 1992 Mechanisms of hyperglycemia-induced insulin resistance in whole body and skeletal muscle of type 1 diabetic patients. Diabetes. 41:571-580.
49. Hother-Nielsen O, Schmitz O, Andersen PH, Beck-Nielsen H, Pedersen O. 1989 Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes. Acta Endocrinol (Copenh). 120:257-265.
50. Nosadini R, Avogaro A, Trevisan R, et al. 1987 Effect of metformin on insulin-stimulated glucose turnover and insulin binding to receptor in type II diabetes. Diabetes Care. 10:62-67.
51. Henry RR, Gumbiner B, Ditzler T, Wallace P, Lyon R, Glauber HS. 1993 Intensive conventional insulin therapy for type II diabetes. Diabetes Care. 16:21-31.
52. Ren J, Marshall BA, Gulve EA, et al. 1993 Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. J Biol Chem. 268:16113-16115.
53. Mueckler M. 1994 Faciliatative glucose transporters. Eur J Biochem. 219:713-725.
54. Giaccari A, Rossetti L. 1992 Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J Clin Invest. 89:36-45.
55. Consoli A, Nurjhan N, Capani F, Gerich J. 1989 Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes. 38:550-557.
56. Massillon D, Barzilai N, Chen W, Hu M, Rossetti L. 1996 Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. J Biol Chem. 271:9871-9874.
57. Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI. 1992 Increased rate of gluconeogenesis in Type II diabetes mellitus. J Clin Invest. 90:1323-1327.
58. Chiasson JL, Atkinson RL, Cherrington AD, et al. 1980 Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man. Metabolism. 29:810-818.
59. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M. 1993 Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. J Clin Invest. 92:1126-11134.
60. Boden G, Chen X, Ruiz J, White JV, Rossetti L. 1994 Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest. 93:2438-2446.
61. Clore JN, Glickman PS, Nestler JE, Blackard WG. 1991 In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans. Am J Physiol. 261:E425-E429.
62. Katz H, Butler P, Homan M, Zerman A, Caumo A, Cobelli C, Rizza R. 1993 Hepatic and extrahepatic insulin action in humans: measurement in the absence of non-steady-state error. Am J Physiol. 264:E561-E566.
63. Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA. 1986 Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. J Clin Invest. 77:1525-1532.
64. Mitrakou A, Kelley D, Veneman T, et al. 1990 Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. Diabetes. 39:1381-1390.
65. Féry F, Balasse EO. 1994 Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. Diabetes. 43:1418-1425.
66. Kelley D, Mokan M, Veneman T. 1994 Impaired postprandial glucose utilization in non-insulin-dependent diabetes mellitus. Metabolism. 43:1549-1557.
67. Ferrannini E, Simonson DC, Katz LD, et al. 1988 The disposal of an oral glucose load in patients with non-insulin-dependent diabetes. Metabolism. 37:79-85.
68. Simonson DC, Ferrannini E, Bevilacqua S, et al. 1984 Mechanism of improvement in glucose metabolism after chronic glyburide therapy. Diabetes. 33:838-845.
69. Cersosimo E, Judd RL, Miles JM. 1994 Insulin regulation of renal glucose metabolism in conscious dogs. J Clin Invest. 93:2584-2589.
70. Stumboll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J. 1995 Uptake and release of glucose by the human kidney. J Clin Invest. 96:2528-2533.