Inhibition of MEK induces Fas expression and apoptosis in lymphomas overexpressing Ras

Leukemia and Lymphoma

Volumn 43, Issue 7, 2002, Pages 1469-1474

  Kalas, Wojciech ^a   Kisielow, Pawel ^a   Strzadala, Leon ^a  

^a INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

Author keywords

Apoptosis; ERK; Fas; MEK; MKK1; PI3K

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MORPHOLINE DERIVATIVE;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; GENE ACTIVITY; GENE OVEREXPRESSION; LYMPHOMA; LYMPHOMA CELL; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN TARGETING; THYMOCYTE; THYMUS; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; THYMOMA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; CHROMONES; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; LYMPHOMA; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; RAS PROTEINS; SIGNAL TRANSDUCTION; THYMUS NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0036306363     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819022386815     Document Type: Article

References (27)

1. "Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells-a mechanism of immune evasion?"
2. "Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape"
3. "Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium"
4. "Decreased Fas antigen receptor expression in testicular tumor cell lines derived from polyomavirus large T-antigen transgenic mice"
5. "Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells"
6. "Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras"
7. "Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas"
8. "The Ras superfamily of GTPases"
9. "Increasing complexity of Ras signal transduction: Involvement of Rho family proteins"
10. "Role of thymic selection in the development of thymic lymphomas in TCR transgenic mice"
11. "Overexpression of Ras, Raff and L-myc but not Bcl-2 family proteins is linked with resistance to TCR-mediated apoptosis and tumorigenesis in thymic lymphomas from TCR transgenic mice"
12. "Signaling by dual specificity kinases"
13. "Thymic lymphomas are resistant to Nur77-mediated apoptosis"
14. "Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4 + 8 + thymocytes"
15. "Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis"
16. "Measurement of protein using bicinchoninic acid"
17. "Cleavage of structural proteins during the assembly of the head of bacteriophage T4"
18. "Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications"
19. "A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry"
20. "Pharmacologic inhibitors of MKK1 and MKK2"
21. "Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes"
22. "Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes"
23. "Phosphorylation and regulation of Raf by Akt (protein kinase B)"
24. "Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras"
25. "p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes"
26. "Targets of p56(lck) activity in immature thymoblasts: Stimulation of the Ras/Raf/MAPK pathway"
27. 2+-mediated apoptosis through a protein kinase A-independent mechanism"