Role of thymic selection in the development of thymic lymphomas in TCR transgenic mice

International Immunology

Volumn 9, Issue 1, 1997, Pages 127-138

  Strzadala, Leon ^a   Miazek, Arkadiusz ^b   Matuszyk, Janusz ^a   Kisielow, Pawel ^b  

^a INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

TCR; Thymic lymphoma; Thymic selection; Transgenic mouse; Turner immunology

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL TRANSFORMATION; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL TOLERANCE; KINETICS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THYMOCYTE; THYMUS LYMPHOMA; TRANSGENE;

ANIMALS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; H-2 ANTIGENS; IMMUNOPHENOTYPING; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOMA; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; THYMUS NEOPLASMS;

EID: 0031040557     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.1.127     Document Type: Article

References (51)

1. Brinster, R. L. 1974. The effect of cells transferred into the mouse blastocyst on subsequent development. J. Exp. Med. 140:1049.
2. Papaioannou, V. E., McBurney, M. W., Gardner, R. L. and Evans, M. J. 1975. Fate of teratocarcinoma cells injected into early mouse embryo. Nature 258:70.
3. Sachs, L. 1978. Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia. Nature 274:535.
4. Sachs, L. 1995. The adventures of a biologist: prenatal diagnosis, hematopoiesis, leukemia, carcinogenesis, and tumor suppression. Adv. Cancer Res. 66:1.
5. Kisielow, P. and von Boehmer, H. 1995. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58:87.
6. Kisielow, P., Leiserson, W. and von Boehmer, H. 1984. Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin-2 producing cells. J. Immunol. 133:1117.
7. Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M. J., Hayday, A. C. and von Boehmer, H. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell 75:283.
8. Fehling, H. J., Krotkova, A., Saint-Ruf, C. and von Boehmer, H. 1995. Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells. Nature 375:795.
9. von Boehmer, H., Kishi, H., Borgulya, P., Scott, B., van Ewijk, W., Teh, H. and Kisielow, P. 1989. Control of T-cell development by the TCRαβ for antigen. Cold Spring Harbor Symp. Quant. Biol. LIV:111.
10. Mombaerts, P., Clarke, A. R., Rudnicki, M. A., Iacomini, J., Itohara, S., Lafaille, J. J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M. L. and Tonegawa, S. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360:225.
11. lo thymocytes: expression of CD44, CD25 and early expression of TCR α mRNA. Eur. J. Immunol. 23:2109.
12. Groettrup, M. and von Boehmer, H. 1993. T cell receptor β chain dimers on immature thymocytes from normal mice. Eur. J. Immunol. 23:1393.
13. Kisielow, P. and von Boehmer, H. 1990. Negative and positive selection of immature thymocytes: timing and the role of the ligand for αβ T cell receptor. Semin. Immunol. 2:35.
14. + thymocytes. Nature 333:742.
15. Kisielow, P., Teh, H.-S., Bluthmann, H. and von Boehmer, H. 1988. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730.
16. Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russel, J. H. and Loh, D. Y. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335:271.
17. Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russel, J. H. and Loh, D. Y. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336:73.
18. + thymocytes in suspension culture by extrathymic antigen presenting cells. Nature 351:150.
19. Swat, W., von Boehmer, H. and Kisielow, P. 1994. Central tolerance: clonal deletion or clonal arrest? Eur. J. Immunol. 24:485.
20. Scott, B., Bluthmann, H., Teh, H.-S. and von Boehmer, H. 1989. The generation of mature T cells requires interaction of the αβ T cell receptor with major histocompatibility antigens. Nature 338, 595.
21. lOW thymocytes contain precursors of mature T cells. Eur. J. Immunol. 24:1010.
22. Huesmann, M., Scott, B., Kisielow, P. and von Boehmer, H. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66:533.
23. Kisielow, P. and Miazek, A. 1995. Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor. J. Exp. Med. 181:1975.
24. k) haplotypes. Ann. Warsaw Agricult. Univ.-Animal Sci. 32:3.
25. Teh, H-S., Kisielow, P., Scott, B., Kishi, H., Uematsu, Y., Bluthmann, H. and von Boehmer, H. 1988. Thymic major histocompatibility complex antigens and the αβ T cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335:229.
26. Stearz, U. D., Rammensee, H, G., Benedetto, J. D. and Bevan, M. J. 1985. Characterization of a monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. J. Immunol. 143:3994.
27. Kubo, R. T., Born, W., Kappler, J. W., Marrack, P. and Pigeon, M. 1989. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142:2736.
28. Becker, M. L. B., Near, R., Mudgett-Hunter, M., Margolies, M. N., Kubo, R. T., Kaye, J. and Hedrick, S. M. 1989. Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell 58:911.
29. Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. and Bluestone, J. A. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl Acad. Sci. USA 84:1374.
30. Springer, T., Galfre, G., Secher, D. S. and Milstein, C. 1978. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur. J. Immunol. 8:539.
31. Malek T. R., Robb, R. J. and Shevach, E. M. 1983. Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex. Proc. Natl Acad. Sci. USA 80:5694.
32. + thymocytes. Eur. J. Immunol. 23:739.
33. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271.
34. Adams, J. M. and Cory, S. 1991. Transgenic models of tumor development. Science 254:1161.
35. Seldin, D. C. 1995. New models of lymphoma in transgenic mice. Curr. Opin. Immunol. 7:665.
36. Weissman, I. L. and McGrath, M. S. 1982. Retrovirus lymphomagenesis: relationship of normal immune receptors to malignant cell proliferation. Curr. Topics Microbiol. Immunol. 98:103.
37. Friedman, D. F., Cho, E. A., Goldman, J., Carmack, C. E., Besa, E. C., Hardy, R. R. and Silberstein, L. E. 1991. The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma. J. Exp. Med. 174:525.
38. Zelenetz, A. D., Chen, T. T. and Levy, R. 1992. Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J. Exp. Med. 176:1137.
39. Sen-Majumdar, A., Weissman, I. L., Hansteen, G., Marian, J., Waller, E. K. and Lieberman, M. 1994. Radiation leukemia virus-induced thymic lymphomas express a restricted repertoire of T-cell receptor Vβ gene products. J. Virol. 68:1165.
40. O'Neill, H. C. 1994. Growth regulation of a T-cell lymphoma via the T-cell receptor. Leukemia Res. 18:23.
41. Schroeder, H. W. and Dighiero, G. 1994. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol. Today 15:288.
42. De Heer, C., de Geus, B., Schuurman, H. J., van Loveren, H. and Rozing, J. 1992. Vβ gene family usage in spontaneous lymphomas of AKR mice: evidence for defective clonal deletion. Dev. Immunol. 2:95.
43. Kappler, J.W., Staerz, U., White, J. and Marrack, P. 1988. Self-tolerance eliminates T cells specific for Mis-modified products of the major histocompatibility complex. Nature 332:35.
44. a-encoded antigens. Nature 332:40.
45. + thymocyte subset. Dev. Immunol. 1:255.
46. Sen-Majumdar, A., Guidos, C., Kina, T., Lieberman, M. and Weissman, I. L. 1994. Characterization of preneoplastic thymocytes and of their neoplastic progression in irradiated C57BL/ Ka mice. J. Immunol. 153:1581.
47. Larson, R. C., Fisch, P., Larson, T. A., Lavenir, I., Langford, T., King, G. and Rabbitts, T. H. 1994. T cell tumors of disparate phenotype in mice transgenic for Rbtn-2. Oncogene 9:3675.
48. Purdie, C. A., Harrison, D. J., Peter, A., Dobbie, L., White, S., Howie, S. E. M., Salter, D. M., Bird, C. C., Wyllie, A. H., Hooper, M. L. and Clarke, A. R. 1994. Tumor incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 9:603.
49. Saint-Ruf, C., Ungewiss, K., Groettrup, M., Bruno, L., Fehling, H. J. and von Boehmer, H. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science 266:1208.
50. -) thymic subsets in T-cell receptor αβ transgenic mice. Dev. Immunol. 2:85
51. Kappler, J. W., Roehm, N. and Marrack, P. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49:273.