Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: Prognostic implications

Leukemia and Lymphoma

Volumn 43, Issue 7, 2002, Pages 1375-1381

  Ueda, Chiyoko ^a   Akasaka, Takashi ^a   Ohno, Hitoshi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

BCL6 gene; BCL6 translocation; Clinical features; Diffuse large B cell lymphoma; Non Ig partner gene; Overall survival

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN; PROTEIN BCL 6; DNA BINDING PROTEIN; ONCOPROTEIN; TRANSCRIPTION FACTOR;

5' UNTRANSLATED REGION; ANIMAL CELL; B CELL LYMPHOMA; CANCER SURVIVAL; CARCINOGENESIS; CELL NUCLEUS; CHROMOSOMAL LOCALIZATION; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION 3; CONTROLLED STUDY; FUSION GENE; GENE AMPLIFICATION; GENE FUSION; GENE LOCUS; GENE REARRANGEMENT; GENE SEQUENCE; GENE TRANSLOCATION; GENETIC TRANSFECTION; HUMAN; IMMUNOGLOBULIN GENE; INVERSE POLYMERASE CHAIN REACTION; LARGE CELL LYMPHOMA; LYMPH NODE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN EXPRESSION; REVIEW; STAINING; TREATMENT OUTCOME; BREAST TUMOR; FEMALE; GENETICS; MALE; MORTALITY;

BREAST NEOPLASMS; DNA-BINDING PROTEINS; FEMALE; HUMANS; LYMPHOMA, B-CELL; LYMPHOMA, LARGE-CELL, DIFFUSE; MALE; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TREATMENT OUTCOME;

EID: 0036304856     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190290033305     Document Type: Review

References (63)

1. "Diffuse large cell lymphoma"
2. "World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the clinical advisory committee meeting-Airlie House, Virginia, November 1997"
3. "Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC/immunoglobulin heavy-chain fusion gene"
4. "Immunophenotypic and genotypic markers of follicular center cell neoplasia in diffuse large B-cell lymphomas"
5. "Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: Correlation with 3q27 and 18q21 chromosomal abnormalities"
6. "Rearrangements of bcl-6, bcl-2, c-myc and 6q deletion in B-diffuse large-cell lymphoma: Clinical relevance in 71 patients"
7. "Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma"
8. "De novo CD5-positive diffuse large B-cell lymphoma: Clinical characteristics and therapeutic outcome"
9. "Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling"
10. "Molecular features of B-cell lymphoma"
11. "t(3;22)(q27;q11): A novel translocation associated with diffuse non-Hodgkin's lymphoma"
12. "Translocations involving band 3q27 and Ig gene regions in non-Hodgkin's lymphoma"
13. "LAZ3 rearrangements in non-Hodgkin's lymphoma: Correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients"
14. "Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma"
15. "Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma"
16. "Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkin's lymphomas: Results of rearrangement and gene expression studies and a mutational analysis of coding region sequences"
17. "Rearrangement of the BCL6 gene in B-cell lymphoid neoplasms: Comparison with lymphomas associated with BCL2 rearrangement"
18. "Pathogenetic and clinical implications of Bcl-6 and Bcl-2 gene configuration in nodal diffuse large B-cell lymphomas"
19. "Significance of rearrangement of the BCL6 gene in B-cell lymphoid neoplasms"
20. "Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays"
21. "The organization of the BCL6 gene"
22. "LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas"
23. "Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein"
24. "The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo"
25. "BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor"
26. "Multiple domains participate in distance-independent LAZ3/BCL6-mediated transcriptional repression"
27. "Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein"
28. "The LAZ3(BCL6) oncoprotein recruits a SMRT/mSINA/histone deacetylase containing complex to mediate transcriptional repression"
29. "The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation"
30. "Disruption of the Bcl6 gene results in an impaired germinal center formation"
31. "Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma"
32. "Detection of 14q32 translocation in B-cell malignancies by in situ hybridization with yeast artificial chromosome clones containing the human IgH gene locus"
33. "Fluorescence in situ hybridization identifies new chromosomal changes involving 3q27 in non-Hodgkin's lymphomas with BCL6/LAZ3 rearrangement"
34. "Translocation (3;14)(q27;q11): A new variant translocation in a patient with non-Hodgkin's lymphoma of B-cell type with BCL6 rearrangement"
35. "A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5′ regulatory region of BCL6 with a novel H4 histone gene"
36. "A recurrent nonrandom translocation (3;7)(q27;p12) associated with BCL-6 gene rearrangement in B-cell diffuse large cell lymphoma"
37. "TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation"
38. "The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/BCL6 gene by t(3;11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231)"
39. "Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5′-RACE and LA-PCR analyses of biopsy samples"
40. "Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma"
41. "Identification and characterization of BCL6 translocation partner genes in primary gastric high-grade B-cell lymphoma: Heat shock protein 89 alpha is a novel fusion partner gene of BCL6"
42. "The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma"
43. "The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma"
44. "Heterologous promoters fused to BCL6 by chromosomal translocations affecting band 3q27 cause its deregulated expression during B-cell differentiation"
45. "Detection of reciprocal fusion 5′-BCL6/partner-3′ transcripts in lymphomas exhibiting reciprocal BCL6 translocations"
46. "Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation"
47. "Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma"
48. "Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas"
49. "Mechanisms of chromosomal translocations in B cell lymphomas"
50. "Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes"
51. "Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction"
52. "Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large- cell lymphoma"
53. "High incidence of BCL-6 gene rearrangement in diffuse large B-cell lymphoma of primary gastric origin"
54. "Nonimmunoglobulin (non-Ig)/BCL6 gene fusion in diffuse large B-cell lymphoma results in worse prognosis than Ig/BCL6"
55. "Lymphomas of the breast: Pathology and clinical behavior"
56. "Non-Hodgkin's lymphoma involving bilateral breasts"
57. "BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts"
58. "BCL-6 protein is expressed in germinal-center B cells"
59. "A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells"
60. "Differential expression of BCL-6, CD138/syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas"
61. "Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma"
62. "The alpha chain of the nascent polypeptide-associated complex function as a transcriptional coactivator"
63. "Immunoglobin (Ig)/BCL6 versus non-Ig/BCL6 gene fusion in diffuse large B-cell lymphoma corresponds to a high-versus low-level expression of BCL6 mRNA"