A recurring translocation, t(3;6)(q27;p21), in non-hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene

Cancer Research

Volumn 57, Issue 1, 1997, Pages 7-12

  Akasaka, Takashi ^a   Miura, Ikuo ^b   Takahashi, Naoto ^b   Akasaka, Hiroshi ^a   Yonetani, Noboru ^a   Ohno, Hitoshi ^a   Fukuhara, Shirou ^c   Okuma, Minoru ^a  

^a KYOTO UNIVERSITY   (Japan)

^b AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; IMMUNOGLOBULIN;

ARTICLE; CHROMOSOME BAND; CHROMOSOME MAP; CHROMOSOME TRANSLOCATION; DNA PROBE; DNA REPLICATION; DNA STRAND BREAKAGE; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE CLUSTER; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE ISOLATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHODGKIN LYMPHOMA; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING;

BASE SEQUENCE; BLOTTING, SOUTHERN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 6; DNA PRIMERS; HUMANS; KARYOTYPING; LYMPHOMA, B-CELL; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSLOCATION, GENETIC;

EID: 0031028263     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Cline, M. J. The molecular basis of leukemia. N. Engl. J. Med., 330: 328-336, 1994.
2. Miki, T., Kawamata, N., Hirosawa, S., and Aoki, N. Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Krüppel-like zinc-finger protein. Blood, 83: 26-32, 1994.
3. Bastard, C., Deweindt, C., Kerckaert, J. P., Lenormand, B., Rossi, A., Pezzella, F., Fruchart, C., Duval, C., Monconduit, M., and Tilly, H. LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood, 83: 2423-2427, 1994.
4. Muramatsu, M., Akasaka, T., Kadowaki, N., Ohno, H., Yamabe, H., Edamura, S., Doi, S., Mori, T., Okuma, M., and Fukuhara, S. Rearrangement of the BCL6 gene in B-cell lymphoid neoplasms: comparison with lymphomas associated with BCL2 rearrangement. Br. J. Haematol., 93: 911-920, 1996.
5. Kluin, P. M. bcl-6 in lymphoma - sorting out a wastebasket? N. Engl. J. Med., 331: 116-118, 1994.
6. Mitelman, F. (ed). Catalog of chromosome aberrations in cancer. New York: Wiley-Liss, Inc., 1991.
7. Miura, I., Ohshima, A., Takahashi, N., Hashimoto, K., Nimura, T., Utsumi, S., Saito, M., Miki, T., Hirosawa, S., and Miura, A. B. A new nonrandom chromosomal translocation t(3;6)(q27;p21.3) associated with BCL6 rearrangement in two patients with non-Hodgkin's lymphoma. Int. J. Hematol., 64: 249-256, 1996.
8. Ohno, H., Kerckaert, J. P., Bastard, C., and Fukuhara, S. Heterogeneity in B-cell neoplasms associated with rearrangement of the LAZ3 gene on chromosome band 3q27. Jpn. J. Cancer Res., 85: 592-600, 1994.
9. Deweindt, C., Kerckaert, J. P., Tilly, H., Quief, S., Nguyen, V. C., and Bastard, C. Cloning of a breakpoint cluster region at band 3q27 involved in human non-Hodgkin's lymphoma. Genes Chromosomes Cancer, 8: 149-154, 1993.
10. Takahashi, E., Yamakawa, K., Nakamura, Y., and Hori, T. A high resolution cytogenetic map of human chromosome 3: localization of 291 new cosmid markers by direct R-banding fluorescence in situ hybridization. Genomics, 13: 1047-1055, 1992.
11. Sierra, F., Stein, G., and Stein, J. Structure and in vitro transcription of a human H4 histone gene. Nucleic Acids Res., 11: 7069-7086, 1983.
12. van Wijnen, A. J., van den Ent, F. M. I., Lian, J. B., Stein, J. L., and Stein, G. S. Overlapping and CpG methylation-sensitive protein-DNA interactions at the histone H4 transcriptional cell cycle domain: distinctions between two human H4 gene promoters. Mol. Cell. Biol., 12: 3273-3287, 1992.
13. Stein, G. S., Stein, J. L., van Wijnen, A. J., and Lian, J. B. Regulation of histone gene expression. Curr. Opin. Cell Biol., 4: 166-173, 1992.
14. Birnstiel, M. L., Busslinger, M., and Strub, K. Transcription termination and 3′ processing: the end is in site! Cell. 41: 349-359, 1985.
15. Heintz, N., Zernik, M., and Roeder, R. G. The structure of the human histone genes: clustered but not tandemly repeated. Cell, 24: 661-668, 1981.
16. Tripputi, P., Emanuel, B. S., Croce, C. M., Green, L. G., Stein, G. S., and Stein, J. L. Human histone genes map to multiple chromosomes. Proc. Natl. Acad. Sci. USA, 83: 3185-3188, 1986.
17. 0 gene are clustered on chromosome 6. Genomics. 16: 649-654, 1993.
18. Bernard, O. A., and Berger, R. Molecular basis of 11q23 rearrangements in hematopoietic proliferations. Genes Chromosomes Cancer, 13: 75-85, 1995.
19. Dallery, E., Galiègue-Zouitina, S., Collyn-d'Hooghe, M., Quief, S., Denis, C., Hildebrand, M-P., Lantoine, D., Deweindt, C., Tilly, H., Bastard, C., and Kerckaert, J-P. TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. Oncogene, 10: 2171-2178, 1995.
20. Galiègue-Zouitina, S., Quief, S., Hildebrand, M-P., Denis, C., Lecocq, G., Collyn-d'Hooghe, M., Bastard, C., Yuille, M., Dyer, M. J. S., and Kerckaert, J. P. The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/BCL6 gene by t(3;11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231). Leukemia (Baltimore), 10: 579-587, 1996.
21. Ye, B. H., Chaganti, S., Chang, C-C., Niu, H., Corradini, P., Chaganti, R. S. K., and Dalla-Favera, R. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J., 14: 6209-6217, 1995.
22. Allman, D., Jain, A., Dent, A., Maile, R. R., Selvaggi, T., Kehry, M. R., and Staudt, L. M. BCL6 expression during B-Cell activation. Blood, 87: 5257-5268, 1996.
23. Ramsey-Ewing, A., van Wijnen, A. J., Stein, G. S., and Stein, J. L. Delineation of a human histone H4 cell cycle element in vivo: the master switch for H4 gene transcription. Proc. Natl. Acad. Sci. USA. 91: 4475-4479, 1994.
24. van Wijnen, A. J., Aziz, F., Grana, X., De Luca, A., Desai, R. K., Jaarsveld, K., Last, T. J., Soprano, K., Giordano, A., Lian, J. B., Stein, J. L., and Stein, G. S. Transcription of histone H4, H3 and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-relaled protein. Proc. Natl. Acad. Sci. USA. 91: 12882-12886, 1994.
25. Vaughan, P. S., Aziz. F., van Wijnen, A. J., Wu, S., Harada, H., Taniguchi, T., Soprano, K. J., Stein, J. L., and Stein, G. S. Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2. Nature (Lond.), 377: 362-365, 1995.
26. van Wijnen, A. J., Choi, T. K., Owen, T. A., Wright, K. L., Lian, J. B., Jaenisch, R., Stein, J. L., and Stein, G. S. Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice. Proc. Natl. Acad. Sci. USA, 88: 2573-2577, 1991.