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Volumn 75, Issue 1, 1997, Pages 69-75

Characterization of a polymorphism in NAD(P)H: Quinone oxidoreductase (DT-diaphorase)

Author keywords

Chemoprevention; Chemotherapy; DT diaphorase; NAD(P)H:quinone oxidoreductase; Polymorphism

Indexed keywords

MESSENGER RNA; MUTANT PROTEIN; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

EID: 0031021280     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.11     Document Type: Article
Times cited : (295)

References (40)
  • 1
    • 0028243181 scopus 로고
    • Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases
    • Beall HD, Mulcahy RT, Siegel D, Traver RD, Gibson NW and Ross D (1994) Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases. Cancer Res 54: 3196-3201
    • (1994) Cancer Res , vol.54 , pp. 3196-3201
    • Beall, H.D.1    Mulcahy, R.T.2    Siegel, D.3    Traver, R.D.4    Gibson, N.W.5    Ross, D.6
  • 2
    • 0019142866 scopus 로고
    • Increase of NAD(P)H:quinone reductase by dietary antioxidants: Possible role in protection against carcinogenesis and toxicity
    • Benson A, Hunkeler MJ and Talalay P (1980) Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc Natl Acad Sci USA 77: 5216-5220
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 5216-5220
    • Benson, A.1    Hunkeler, M.J.2    Talalay, P.3
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Biochemistry 72: 248-254
    • (1976) Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.1
  • 4
    • 0026240006 scopus 로고
    • Relevance of metabolic polymorphisms to human carcinogenesis: Evaluation of epidemiologic evidence
    • Caporaso N, Landi MT and Vineis P (1991) Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence. Pharmacogenetics 1:4-19
    • (1991) Pharmacogenetics , vol.1 , pp. 4-19
    • Caporaso, N.1    Landi, M.T.2    Vineis, P.3
  • 5
    • 0019013616 scopus 로고
    • Human FAD-dependent NAD(P)H diaphorase
    • Edwards YH, Potter J, and Hopkinson DA (1980) Human FAD-dependent NAD(P)H diaphorase. Biochem J 187: 429-436
    • (1980) Biochem J , vol.187 , pp. 429-436
    • Edwards, Y.H.1    Potter, J.2    Hopkinson, D.A.3
  • 6
    • 0028178833 scopus 로고
    • Expression of NAD(P)H:quinone oxidoreductase and glutathione S-transferases alpha and pi in human renal cell carcinoma and in kidney cancer-derived cell lines
    • Eickelmann P, Ebert T, Warskulat U, Schulz WA and Sies H (1994a) Expression of NAD(P)H:quinone oxidoreductase and glutathione S-transferases alpha and pi in human renal cell carcinoma and in kidney cancer-derived cell lines. Carcinogenesis 15: 219-225
    • (1994) Carcinogenesis , vol.15 , pp. 219-225
    • Eickelmann, P.1    Ebert, T.2    Warskulat, U.3    Schulz, W.A.4    Sies, H.5
  • 7
    • 0028467127 scopus 로고
    • Loss of heterozygosity at the NAD(P)H: Quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line
    • Eickelmann P, Schulz WA, Ronde D, Schmitz-Drager B and Sies H (1944b) Loss of heterozygosity at the NAD(P)H: quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line. Biol Chem Hoppe-Seyler 375: 439-445
    • (1944) Biol Chem Hoppe-Seyler , vol.375 , pp. 439-445
    • Eickelmann, P.1    Schulz, W.A.2    Ronde, D.3    Schmitz-Drager, B.4    Sies, H.5
  • 9
    • 77957000392 scopus 로고
    • DT-Diaphorase
    • Ernster L (1967) DT-Diaphorase. Methods Enzymol 10: 309-317
    • (1967) Methods Enzymol , vol.10 , pp. 309-317
    • Ernster, L.1
  • 10
    • 0015881843 scopus 로고
    • A rapid micromethod for determination of FMN and FAD in mixtures
    • Faeder EJ and Siegel LM (1973) A rapid micromethod for determination of FMN and FAD in mixtures. Anal Biochem 53: 332-336
    • (1973) Anal Biochem , vol.53 , pp. 332-336
    • Faeder, E.J.1    Siegel, L.M.2
  • 11
    • 0027055783 scopus 로고
    • Cell-specific metabolism in mouse bone marrow stroma. Studies of activation and detoxification of benzene metabolites
    • Ganousis LG, Goon D, Zyglewska T, Wu KK and Ross D (1992) Cell-specific metabolism in mouse bone marrow stroma. Studies of activation and detoxification of benzene metabolites. Mol Pharmacol 42: 531-536
    • (1992) Mol Pharmacol , vol.42 , pp. 531-536
    • Ganousis, L.G.1    Goon, D.2    Zyglewska, T.3    Wu, K.K.4    Ross, D.5
  • 12
    • 0027048768 scopus 로고
    • Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity
    • Gibson NW, Hartley JA, Butler J, Siegel D and Ross D (1992) Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity. Mol Pharmacol 42: 531-536
    • (1992) Mol Pharmacol , vol.42 , pp. 531-536
    • Gibson, N.W.1    Hartley, J.A.2    Butler, J.3    Siegel, D.4    Ross, D.5
  • 14
    • 0027983085 scopus 로고
    • Pharmacogenetic phenotyping and genotyping. Present status and future potential
    • Gonzalez FJ and Idle JR (1994) Pharmacogenetic phenotyping and genotyping. Present status and future potential. Clin Pharmacokinet 26: 59-70
    • (1994) Clin Pharmacokinet , vol.26 , pp. 59-70
    • Gonzalez, F.J.1    Idle, J.R.2
  • 15
    • 0026319263 scopus 로고
    • Human NAD(P)H:quinone oxidoreductase (NQOI) gene structure and induction by dioxin
    • Jaiswal AK (1991) Human NAD(P)H:quinone oxidoreductase (NQOI) gene structure and induction by dioxin. Biochemistry 30: 10647-10653
    • (1991) Biochemistry , vol.30 , pp. 10647-10653
    • Jaiswal, A.K.1
  • 16
    • 0023724493 scopus 로고
    • Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16
    • Jaiswal KA, Mcbride OW, Adesnik M and Nebert DW (1988) Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. J Biol Chem 263: 13572-13578
    • (1988) J Biol Chem , vol.263 , pp. 13572-13578
    • Jaiswal, K.A.1    Mcbride, O.W.2    Adesnik, M.3    Nebert, D.W.4
  • 17
    • 0029151835 scopus 로고
    • Presence of a heterozygous substitution and its relationship to DT-diaphorase activity
    • Kuehl BL, Paterson JWE, Peacock JW, Paterson MC, and Rauth AM (1995) Presence of a heterozygous substitution and its relationship to DT-diaphorase activity. Br J Cancer 72: 555-561
    • (1995) Br J Cancer , vol.72 , pp. 555-561
    • Kuehl, B.L.1    Paterson, J.W.E.2    Peacock, J.W.3    Paterson, M.C.4    Rauth, A.M.5
  • 18
    • 0029636702 scopus 로고
    • Re: Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer
    • Kolesar JM, Burris HA and Kuhn JG (1995) Re: detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer. J Natl Cancer Inst 87: 1022-1024
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1022-1024
    • Kolesar, J.M.1    Burris, H.A.2    Kuhn, J.G.3
  • 19
    • 0029068515 scopus 로고
    • The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprevention and chemotherapy: Mechanism of the two-electron reduction
    • LI R, Bianchet MA, Talalay P and Amzel LM (1995) The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprevention and chemotherapy: mechanism of the two-electron reduction. Proc Natl Acad Sci USA 92: 8846-8850
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8846-8850
    • Li, R.1    Bianchet, M.A.2    Talalay, P.3    Amzel, L.M.4
  • 20
    • 0026499189 scopus 로고
    • Identification of a glycine-rich sequence as an NAD(P)H-binding site and tyrosine 128 as a dicumarol-binding site in rat liver NAD(P)H:quinone oxidoreductase by site-directed mutagenesis
    • MA Q, CUI K, Xiao F, LU Ayh and Yang CS (1992) Identification of a glycine-rich sequence as an NAD(P)H-binding site and tyrosine 128 as a dicumarol-binding site in rat liver NAD(P)H:quinone oxidoreductase by site-directed mutagenesis. J Biol Chem 267: 22298-22304
    • (1992) J Biol Chem , vol.267 , pp. 22298-22304
    • Ma, Q.1    Cui, K.2    Xiao, F.3    Lu, A.4    Yang, C.S.5
  • 21
    • 0026700546 scopus 로고
    • Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin Cl
    • Malkinson AM, Siegel D, Forrest GL, Gazdar AF, Oie HK, Chan DC, Bunn PA, Mabry M, Dykes DJ, Harrison SD and Ross D (1992) Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl. Cancer Res 52: 4752-4757
    • (1992) Cancer Res , vol.52 , pp. 4752-4757
    • Malkinson, A.M.1    Siegel, D.2    Forrest, G.L.3    Gazdar, A.F.4    Oie, H.K.5    Chan, D.C.6    Bunn, P.A.7    Mabry, M.8    Dykes, D.J.9    Harrison, S.D.10    Ross, D.11
  • 22
    • 0025799465 scopus 로고
    • DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family
    • Marshall RS, Paterson MC and Rauth AM (1991a) DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family. Carcinogenesis 12: 1175-1180
    • (1991) Carcinogenesis , vol.12 , pp. 1175-1180
    • Marshall, R.S.1    Paterson, M.C.2    Rauth, A.M.3
  • 23
    • 0026032132 scopus 로고
    • Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual
    • Marshall RS, Paterson MC and Rauth AM (1991b) Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual. Biochem Pharmacol 41: 1351-1360
    • (1991) Biochem Pharmacol , vol.41 , pp. 1351-1360
    • Marshall, R.S.1    Paterson, M.C.2    Rauth, A.M.3
  • 24
    • 0025201144 scopus 로고
    • A simple and fast method to extract RNA from tissue culture cells
    • Peppel K and Baglioni C (1990) A simple and fast method to extract RNA from tissue culture cells. Biotechniques 9: 711-713
    • (1990) Biotechniques , vol.9 , pp. 711-713
    • Peppel, K.1    Baglioni, C.2
  • 25
    • 0027376465 scopus 로고
    • Semi-quantitative measurement of gene expression byRT-PCR: A cautionary tale
    • Phillips RM, Sarang M and Gibson NW (1993) Semi-quantitative measurement of gene expression byRT-PCR: a cautionary tale. Int J Oncol 3: 1097-1102
    • (1993) Int J Oncol , vol.3 , pp. 1097-1102
    • Phillips, R.M.1    Sarang, M.2    Gibson, N.W.3
  • 26
    • 0026589840 scopus 로고
    • Rapid detection of inducers of enzymes that protect against carcinogens
    • Prochaska HJ, Santamaria AB and Talalay P (1992) Rapid detection of inducers of enzymes that protect against carcinogens. Proc Natl Acad Sci USA 89: 2394-2398
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2394-2398
    • Prochaska, H.J.1    Santamaria, A.B.2    Talalay, P.3
  • 27
    • 0025131538 scopus 로고
    • Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma
    • Ross D, Siegel D, Gibson NW, Pacheco D, Thomas DJ, Reasor M and Wierda D (1990) Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma. Free Rad Res Commun 8: 373-381
    • (1990) Free Rad Res Commun , vol.8 , pp. 373-381
    • Ross, D.1    Siegel, D.2    Gibson, N.W.3    Pacheco, D.4    Thomas, D.J.5    Reasor, M.6    Wierda, D.7
  • 28
    • 0027295491 scopus 로고
    • DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of milomycin C
    • Ross D, Siegel D, Beall HD, Prakash AS, Mulcahy RT and Gibson NW (1993) DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of milomycin C. Cancer Metast Rev 12: 83-101
    • (1993) Cancer Metast Rev , vol.12 , pp. 83-101
    • Ross, D.1    Siegel, D.2    Beall, H.D.3    Prakash, A.S.4    Mulcahy, R.T.5    Gibson, N.W.6
  • 29
    • 0029781444 scopus 로고    scopus 로고
    • A polymorphism in NAD(P)H: Quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity
    • Ross D, Traver RD, Siegel D, Kuehl BL, Misra V and Rauth AM (1996) A polymorphism in NAD(P)H: quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity. Br J Cancer 74: 995-996
    • (1996) Br J Cancer , vol.74 , pp. 995-996
    • Ross, D.1    Traver, R.D.2    Siegel, D.3    Kuehl, B.L.4    Misra, V.5    Rauth, A.M.6
  • 30
    • 0029073531 scopus 로고
    • Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking
    • Rosvold EA, Mcglynn KA, Lustbader ED and Buetow KH (1995a) Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking. Pharmacogenetics 5: 199-206
    • (1995) Pharmacogenetics , vol.5 , pp. 199-206
    • Rosvold, E.A.1    Mcglynn, K.A.2    Lustbader, E.D.3    Buetow, K.H.4
  • 31
    • 0029636702 scopus 로고
    • Re: Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer
    • Rosvold EA, Mcglynn KA, Lustbader ED and Buetow KH (1995b) Re: detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer. J Natl Cancer Ins 87: 1022-1024
    • (1995) J Natl Cancer Ins , vol.87 , pp. 1022-1024
    • Rosvold, E.A.1    Mcglynn, K.A.2    Lustbader, E.D.3    Buetow, K.H.4
  • 33
    • 0025248106 scopus 로고
    • Cytosolic NAD(P)H:(quinone-acceptor) oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol
    • Schlager JJ and Powis G (1990) Cytosolic NAD(P)H:(quinone-acceptor) oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol. Int J Cancer 45: 403-409
    • (1990) Int J Cancer , vol.45 , pp. 403-409
    • Schlager, J.J.1    Powis, G.2
  • 34
    • 0025688249 scopus 로고
    • Metabolism of mitomycin C by DT-diaphorase: Role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells
    • Siegel D, Gibson NW, Preusch, PC and Ross D (1990) Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res 50: 7483-7489
    • (1990) Cancer Res , vol.50 , pp. 7483-7489
    • Siegel, D.1    Gibson, N.W.2    Preusch, P.C.3    Ross, D.4
  • 35
    • 0024386604 scopus 로고
    • Purification by cibacron blue F3GA dye affinity chromatography and comparison of NAD(P)H:quinone reductase (E.C.I.6.99.2) from rat liver cytosol and microsomes
    • Sharkis DH and Swenson RP (1989) Purification by cibacron blue F3GA dye affinity chromatography and comparison of NAD(P)H:quinone reductase (E.C.I.6.99.2) from rat liver cytosol and microsomes. Biochem Biophys Res Commun 161:434-441
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 434-441
    • Sharkis, D.H.1    Swenson, R.P.2
  • 36
    • 0026505943 scopus 로고
    • NAD(P)H:quinone oxidoreductase gene expression in humun colon carcinoma cells: Characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity
    • Traver RD, Horikoshi T, Danenberg KD, Stadlbauer THW, Danenberg PV, Ross D and Gibson NW (1992) NAD(P)H:quinone oxidoreductase gene expression in humun colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Cancer Res 52: 797-802
    • (1992) Cancer Res , vol.52 , pp. 797-802
    • Traver, R.D.1    Horikoshi, T.2    Danenberg, K.D.3    Stadlbauer, T.H.W.4    Danenberg, P.V.5    Ross, D.6    Gibson, N.W.7
  • 37
    • 0012469630 scopus 로고
    • A point mutation in both human lung and colon carcinoma cell lines leading to a loss of DT-diaphorase activity
    • Traver RD, Phillips RM, Gibson NW and Ross D (1995) A point mutation in both human lung and colon carcinoma cell lines leading to a loss of DT-diaphorase activity. Proc Am Assoc Cancer Res 36: 525
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 525
    • Traver, R.D.1    Phillips, R.M.2    Gibson, N.W.3    Ross, D.4
  • 38
    • 0025284525 scopus 로고
    • Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin
    • Walton MI and Workman P (1990) Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin. Biochem Pharmacol 39: 1735-1742
    • (1990) Biochem Pharmacol , vol.39 , pp. 1735-1742
    • Walton, M.I.1    Workman, P.2
  • 39
    • 0021934758 scopus 로고
    • Chemoprevention of cancer
    • Wattenberg LW (1985) Chemoprevention of cancer. Cancer Res 45: 1-8
    • (1985) Cancer Res , vol.45 , pp. 1-8
    • Wattenberg, L.W.1
  • 40
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
    • Zhang Y, Talalay P, Cho CG and Posner GH (1992) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 89: 2399-2403
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3    Posner, G.H.4


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