Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/myelodysplastic syndrome and de novo acute myeloid leukemia

Clinical Cancer Research

Volumn 6, Issue 10, 2000, Pages 4091-4095

  Naoe, Tomoki ^a   Takeyama, Kunihiko ^a   Yokozawa, Toshiya ^a   Kiyoi, Hitoshi ^a   Seto, Masao ^b   Uike, Naokuni ^c   Ino, Teruo ^d   Utsunomiya, Atae ^e   Maruta, Atsuo ^f   Jin nai, Itsuro ^g   Kamada, Nanao ^h   Kubota, Yoshitsugu ⁱ   Nakamura, Hiroyuki ^j   Shimazaki, Chihiro ^k   Horiike, Shigeo ^a   Kodera, Yoshihisa ^l   Saito, Hidehiko ^k   Ueda, Ryuzo ^m   Wiemels, Joseph ⁿ   Ohno, Ryuzo ^o  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c NATIONAL KYUSHU CANCER CENTER   (Japan)

^d FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e KAGOSHIMA UNIVERSITY   (Japan)

^f KANAGAWA CANCER CENTER   (Japan)

^g NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h HIROSHIMA UNIVERSITY   (Japan)

ⁱ KAGAWA UNIVERSITY   (Japan)

^j OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^k KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^l JAPANESE RED CROSS NAGOYA FIRST HOSPITAL   (Japan)

^m NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

ⁿ UNIVERSITY OF CALIFORNIA   (United States)

^o HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; GLUTATHIONE TRANSFERASE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLELISM; ARTICLE; ENZYME ACTIVATION; ETHNOLOGY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; LEUKEMIA; MAJOR CLINICAL STUDY; METABOLIC ACTIVATION; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL;

ADULT; ALLELES; CODON; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON TRANSPORT COMPLEX I; FEMALE; GENE DELETION; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; JAPAN; LEUKEMIA; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MIDDLE AGED; MIXED FUNCTION OXYGENASES; MYELODYSPLASTIC SYNDROMES; NADH, NADPH OXIDOREDUCTASES; POLYMORPHISM, GENETIC; RISK;

EID: 0033755155     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Leukemias and myelodysplastic syndromes secondary to drug, radiation, and environmental exposure
2. Therapy-related myeloid leukemia
3. The molecular pathogenesis of treatment-induced (secondary) leukemias: Foundations for treatment and prevention
4. Association of CYP3A4 genotype with treatment-related leukemia
5. Prevalence of the inactivating 609C → T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia
6. Pharmacogenetics in cancer etiology and chemotherapy
7. Cytochrome P-450-mediated O-demethylation: A route in the metabolic activation of etoposide (VP-16-213)
8. Effects of the ortho-quinone and catechol of the antitumor drug VP-16-213 on the biological activity of single-stranded and double-stranded phi X174 DNA
9. Individualization of cancer therapy based on cytochrome P450 polymorphism: A pharmacogenetic approach
10. Formation of different reaction products with single- and double-stranded DNA by the orthoquinone and the semi-quinone free radical of etoposide (VP-16-213)
11. Mechanism of action of antitumor drug etoposide: A review
12. NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase
13. A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity
14. A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions
15. Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis
16. Biochemical genetics of glutathione-S-transferase in man
17. Human glutathione S-transferase τ (GSTT1): cDNA cloning and the characterization of a genetic polymorphism
18. Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: Influence on cancer susceptibility
19. Genetic risk and carcinogen exposure: A common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer
20. Higher frequency of glutathione S-transferase deletions in black children with acute lymphoblastic leukemia
21. Increased risk for myelodysplastic syndromes in individuals with glutathione transferase τ 1 (GSTT1) gene defect
22. Glutathione S transferase τ 1 gene defects in myelodysplastic syndromes and their correlation with karyotype and exposure to potential carcinogens
23. Therapy-related leukemia and myelodysplastic syndrome: A large-scale Japanese study of clinical and cytogenetic features as well as prognostic factors
24. Randomized study of individualized induction therapy with or without vincristine, and of maintenance-intensification therapy between 4 or 12 courses in adult acute myeloid leukemia. AML-87 Study of the Japan Adult Leukemia Study Group
25. Randomized trials between behenoyl cytarabine and cytarabine in combination induction and consolidation therapy, and with or without ubenimex after maintenance/intensification therapy in adult acute myeloid leukemia
26. No beneficial effect from addition of etoposide to daunorubicin, cytarabine, and 6-mercaptopurine in individualized induction therapy of adult acute myeloid leukemia: The JALSG-AML92 study
27. Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control
28. Molecular evolution of acute myeloid leukaemia in relapse: Unstable N-ras and FLT3 genes compared with p53 gene
29. Re: Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
30. Benzene, NQO1, and genetic susceptibility to cancer
31. 609C→T mutation and rapid fractional excretion of chlorzoxazone
32. Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: Study involving mouse, rat, human, and mouse-rat chimeric enzymes
33. 609C→T polymorphism with a decreased lung cancer risk
34. Cell-specific metabolism in mouse bone marrow stroma: Studies of activation and detoxification of benzene metabolites
35. An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia