Role of damage-sensing/processing genes in the radiation response of haemopoietic in vitro colony-forming cells

International Journal of Radiation Biology

Volumn 78, Issue 7, 2002, Pages 559-566

  Hendry, J H ^a   Hoyes, K P ^a   Wadeson, P ^a   Roberts, S A ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; COLONY FORMING CELL; DNA STRAND BREAKAGE; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE SILENCING; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIATION RESPONSE; RADIOSENSITIVITY; RADIOSENSITIZATION; RECEPTOR UPREGULATION; STRAIN DIFFERENCE;

ANIMALS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA-BINDING PROTEINS; GENES, BCL-2; GENES, P53; HEMATOPOIETIC STEM CELLS; MATHEMATICS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; TRIXIS;

EID: 0036298910     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000210132333     Document Type: Article

References (67)

1. Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53
2. Radiosensitivity increases with differentiation status of murine hemopoietic progenitor cells selected using enriched marrow subpopulations and recombinant growth factors
3. The radiosensitivity of populations of murine hemopoietic colony-forming cells that respond to combinations of growth factors
4. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways
5. Atm-deficient mice: A paradigm of ataxia telangiectasia
6. The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity
7. Radiation induced apoptosis in ataxia telangiectasia homozygote, heterozygote and normal cells
8. Variability in the radiosensivity of normal cells and tissues. Report from a Workshop organised by the European Society for Therapeutic Radiology and Oncology in Edinburgh, UK, 19 September 1998
9. The radiosensitivity of spermatogonia in p53 null mice
10. A severe combined immunodeficiency mutation in the mouse
11. Radiation-induced cell cycle arrest compromised by p21 deficiency
12. Tumors arising in SCID mice share enhanced radiation sensitivity of SCID normal tissues
13. Increased radiosensitivity of granulocyte macrophage colony-forming units and skin fibroblasts in human autosomal recessive severe combined immunodeficiency
14. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents
15. Mice lacking p21CIPI/WAF1 undergo normal development, but are defective in G1 checkpoint control
16. Defective repair of radiation-induced chromosomal damage in scid/scid mice
17. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
18. Effects of genetic background on tumorigenesis in p53-deficient mice
19. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
20. Computerized video time-lapse microscopy studies of ionizing radiation-induced rapid-interphase and mitosis-related apoptosis in lymphoid cells
21. The scid mutation in mice causes a general defect in DNA repair
22. Radiotherapeutic management of medulloblastoma in a pediatric patient with ataxia telangiectasia
23. Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice
24. Genomic instability: Potential contributions to tumour and normal tissue response, and second tumours, after radiotherapy
25. Differential radiosensitising effect of the scid mutation among tissues, studied using high and low dose rates: Implications for prognostic indicators in radiotherapy
26. Response of bone marrow to low LET irradiation
27. P53 deficiency produces fewer regenerating spermatogenic tubules after irradiation
28. p-53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine
29. In vitro clonal assays for murine multipotential and lineage restricted myeloid progenitor cells
30. Effect of bcl-2 deficiency on the radiation response of clonogenic cells in small and large intestine, bone marrow and testis
31. Splitting the ATM: Distinct repair and checkpoint defects in ataxia-telangiectasia
32. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage
33. Low-dose hypersensitivity: Current status and possible mechanisms
34. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
35. Increased sensitivity of scid heterozygous mice to ionizing radiation
36. BCL-2 gene family and the regulation of programmed cell death
37. ATM: The protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia
38. Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle
39. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
40. p21 Wafl/Cipl can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents
41. A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency
42. Chromosomal radiosensitivity in G(2)-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics
43. Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy
44. Chromosomal radiosensitivity during G2 phase and susceptibility to plasmacytoma induction in mice
45. P53 null mice: Damaging the hypothesis?
46. Chromosomal radiosensitivity, cancer predisposition and response to radiotherapy
47. The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts
48. High levels of delayed radiation-induced apoptosis observed in lymphoblastoid cell lines from ataxia-telangiectasia patients
49. Hemopoietic stem-cell compartment of the SCID mouse: Double-exponential survival curve after gamma irradiation
50. Analysis of mitotic cell death caused by radiation in mouse leukaemia L5178Y cells: Apoptosis is the ultimate form of cell death following mitotic failure
51. Regulation of the G2/M transition by p53
52. Cleavage of ATM during radiation-induced apoptosis: Caspase-3-like apoptotic protease as a candidate
53. Radiobiological features of human pluripotent bone marrow progenitor cells (CFU-GEMM)
54. Further characterization of the radiosensitivity of the scid mouse
55. Genetic background influences timing, morphology and dissemination of lymphomas in p53-deficient mice
56. The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest
57. Gamma-ray-induced cell killing and chromosome abnormalities in the bone marrow of p53-deficient mice
58. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
59. Cell-cycle signaling: Atm displays its many talents
60. Loss of atm radiosensitizes multiple p53 null tissues
61. Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
62. Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints
63. Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints
64. Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene