Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead

Amino Acids

Volumn 22, Issue 4, 2002, Pages 297-308

  Chan, C ^a   Yin, H ^a   McKie, J H ^a   Fairlamb, A H ^b   Douglas, K T ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Antiparasitics; Drug leads; Enzyme inhibitors; Glutathione; Rational drug design

Indexed keywords

2 (1H BENZOTRIAZOL 1 YL) 1,1,3,3 TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE; ANTIPROTOZOAL AGENT; ARGININE; BENZYL DERIVATIVE; CARBONYL DERIVATIVE; FUNCTIONAL GROUP; GLUTATHIONE REDUCTASE; IMIDAZOLE DERIVATIVE; LEAD; N (3 IMIDAZOLOPROPYL)GLYCYL N (3 IMIDAZOLOPROPYL)GLYCYLSARCOSINE BENZYLAMIDE; N (3 IMIDAZOLOPROPYL)GLYCYLSARCOSINE BENZYLAMIDE; N BENZYLOXYCARBONYLALANYLARGINYLARGINYL 4 METHOXY BETA NAPHTHYLAMIDE; N BENZYLOYLLEUCYLARGINYLARGINYL BETA NAPHTHYLAMIDE; N NAPHTHOXYACETYL(3 IMIDAZOLOPROPYL)GLYCYL N (3 IMIDAZOLOPROPYL)GLYCYLSARCOSINE BENZYLAMIDE; N TERT BUTYLOXYCARBONYL(3 IMIDAZOLOPROPYL)GLYCINE; N TERT BUTYLOXYCARBONYL(3 IMIDAZOLOPROPYL)GLYCINE ETHYL ESTER; N TERT BUTYLOXYCARBONYL(3 IMIDAZOLOPROPYL)GLYCYL N (3 IMIDAZOLOPROPYL)GLYCYLSARCOSINE BENZYLAMIDE; N TERT BUTYLOXYCARBONYL(3 IMIDAZOLOPROPYL)GLYCYLSARCOSINE BENZYLAMIDE; N TERT BUTYLOXYCARBONYLSARCOSINE BENZYLAMIDE; PEPTIDE DERIVATIVE; RECOMBINANT ENZYME; SARCOSINE BENZYLAMIDE; TRIAZOLE DERIVATIVE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; LEISHMANIA; LEISHMANIASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTOZOAL INFECTION; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPROTOZOAL AGENTS; DRUG DESIGN; GLUTATHIONE REDUCTASE; HUMANS; LEISHMANIA DONOVANI; NADH, NADPH OXIDOREDUCTASES; PEPTOIDS; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0036281756     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007260200016     Document Type: Article

References (44)

1. Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads
2. 1-glutathionylspermidine disulphide at 0.28-nm resolution
3. 2-Amino diphenylsulfides as inhibitors of trypanothione reductase: Modification of the side chain
4. Rationally designed selective inhibitors of trypanothione reductase
5. Cholecystokinin peptidomimetics as selective CCK-B antagonists: Design, synthesis, and in vitro and in vivo biochemical properties
6. New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase
7. Rational design of high affinity tachykinin NK2 receptor antagonists
8. Mechanism of reduction of quinones by Trypanosoma congolense trypanothione reductase
9. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs
10. Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials
11. Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals
12. Effects of covalent modifications on the solid-state folding and packing of N-malonylglycine derivatives
13. Modification of "peptoid" CCK-B antagonists to probe requirements for CCK-B agonist activity
14. Metabolism and functions of trypanothione in the kinetoplastida
15. Trypanothione: A novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids
16. Rational design of peptide-based inhibitors of trypanothione reductase as potential antitrypanosomal drugs
17. Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. structural effects on the inhibition by dibenzazepines based on imipramine
18. New potent inhibitors of trypanothione reductase from Trypanosoma cruzi in the 2-aminodiphenylsulfide series
19. Synthesis of an N-3-guanidinopropylglycine (Narg) derivative as a versatile building block for solid-phase peptide and peptoid synthesis
20. "Subversive" substrates for the enzyme trypanothione disulfide reductase: Alternative approach to chemotherapy of Chagas disease
21. Synthesis and binding affinities of analogues of cholecystokinin-(30-33) as probes for central nervous system cholecystokinin receptors
22. Design of non-peptide agonists and antagonists for neuropeptide receptors
23. Neuropeptides. Function and clinical applications
24. Active site of trypanothione reductase. A target for rational drug design
25. Physical and chemical data Vol I
26. Refined structure of glutathione reductase at 1.54 Å resolution
27. Enzymes of parasite thiol metabolism as drug targets
28. Trypanothione reductase from Trypanosoma cruzi: Purification and characterization of the crystalline enzyme
29. X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-Å resolution
30. Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: Potential rational drug design lead frameworks
31. Fast purification of a functional elongator tRNAmet expressed from a synthetic gene in vivo
32. Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet
33. A combinatorial approach to the discovery of efficient cationic peptoid reagents for gene delivery
34. Folding of the four domains and dimerization are impaired by the Gly446XGlu exchange in human glutathione reductase. Implications for the design of antiparasitic drugs
35. Disulfide-reductase inhibitors as chemotherapeutic agents: The design of drugs for trypanosomiasis and malaria
36. Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases
37. CHUCKLES: A method for representing and searching peptide and peptoid sequences on both monomer and atomic levels
38. Peptoids: A modular approach to drug discovery
39. Combinatorial synthesis of peptidomimetics
40. Human glutathione reductase: Purification of the crystalline enzyme from erythrocytes
41. Synthesis and enzymology of modified N-benzyloxycarbonyl-l-cysteinylglycyl-3,3-dimethylaminopropylamide disulphides as alternative substrates for try-panothione reductase from Trypanosoma cruzi: Part 3
42. The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruziat 2.3 A resolution
43. Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted) glycine peptoid library