Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: Potential rational drug design lead frameworks

Amino Acids

Volumn 20, Issue 2, 2001, Pages 145-153

  McKie, J H ^a   Garforth, J ^a   Jaouhari, R ^a   Chan, C ^a   Yin, H ^a   Besheya, T ^a   Fairlamb, A H ^b   Douglas, K T ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Amino acids; Antiparasitics; Drug leads; Glutathione; Leishmaniasis; Trypanosomiasis

Indexed keywords

AMINO ACID; ANTIPARASITIC AGENT; ENZYME INHIBITOR; GLUTATHIONE REDUCTASE; N BENZYLOXYCARBONYLALANYLARGINYLARGINYL 4 METHOXY BETA NAPHTHYLAMIDE; PEPTIDE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; LEISHMANIASIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TRYPANOSOMIASIS;

DRUG DESIGN; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE REDUCTASE; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NADH, NADPH OXIDOREDUCTASES; OLIGOPEPTIDES; PEPTIDES; SPERMIDINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035083882     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007260170055     Document Type: Article

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