What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas

Leukemia

Volumn 16, Issue 6, 2002, Pages 1086-1098

  Dudley, J P ^a   Mertz, J A ^a   Rajan, L ^a   Lozano, M ^a   Broussard, D R ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

C Myc; Leukemias; Lymphomas; Proto oncogenes; Retroviruses

Indexed keywords

MYC PROTEIN; VIRUS PROTEIN;

CELL TYPE; CONTROLLED STUDY; GENE ACTIVATION; GENE DELETION; GENE IDENTIFICATION; GENE INSERTION; GENE OVEREXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HUMAN; LEUKEMIA; LEUKEMOGENESIS; LONG TERMINAL REPEAT; LYMPHOMA; MOLECULAR CLONING; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTO ONCOGENE; PROVIRUS; RETROVIRUS; REVIEW; SPECIES; TRANSGENE; VIRUS GENE; VIRUS INFECTION;

ANIMALS; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA; LYMPHOMA; ONCOGENES; PROTO-ONCOGENE PROTEINS C-MYC; RETROVIRIDAE; TERMINAL REPEAT SEQUENCES; VIRUS INTEGRATION;

EID: 0036273063     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402451     Document Type: Review

References (193)

1. Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions, by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc
2. Molecular cloning of proviral DNA and structural analysis of the transduced myc oncogene of avian oncovirus CMII
3. Nucleotide sequence of avian carcinoma virus MH2: Two potential oncgenes, one related to avian virus MC29 and the other related to murine sarcoma virus 3611
4. Nucleotide sequence of two overlapping myc-related genes in avian carcinoma virus OK10 and their relation to the myc genes of other viruses and the cell
5. Proteins of the Myc network: Essential regulators of cell growth and differentiation
6. An amino-terminal c-myc domain required for neoplastic transformation activates transcription
7. The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation
8. Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max
9. Myc and Max function as a nucleoprotein complex
10. Control of c-myc regulation in normal and neoplastic cells
11. MYC oncogenes and human neoplastic disease
12. Activation of cellular oncogenes in hemopoietic cells by chromosome translocation
13. Activation of the c-myc oncogene
14. The myc oncogene: Its role in transformation and differentation
15. The pathogenesis of Burkitt's lymphoma
16. Molecular biology of lymphomas
17. Immunoglobulin gene associated chromosomal translocations in B-cell derived tumors
18. Chromosomal translocations in B-cell derived tumors
19. Myc oncogene activation in B and T lymphoid tumours
20. Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3′ side of MYC
21. Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia
22. Translocation between chromosomes 8q24 and 14q11 in T-cell acute lymphoblastic leukemia
23. Molecular cloning of a DNA fragment from human chromosome 14(14q11) involved in T-cell malignancies
24. T-cell acute lymphoblastic leukemias with a t(8;14) possibly involving a c-myc locus and T-cell-receptor alpha-chain genes
25. Deregulation of c-myc by translocation of the alpha-locus of the T-cell receptor in T-cell leukemias
26. Myc-Max-Mad: A transcription factor network controlling cell cycle progression, differentiation and death
27. Action of Myc in vivo - Proliferation and apoptosis
28. c-Myc target genes involved in cell growth, apoptosis, and metabolism
29. Function of the c-Myc oncogenic transcription factor
30. Mechanisms of apoptosis by c-Myc
31. Target genes and cellular regulators of the Myc transcription complex
32. Myc target genes
33. The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights
34. The MYC dualism in growth and death
35. The proto-oncogene c-myc and apoptosis
36. The many roles of c-Myc in apoptosis
37. Transforming properties of the HTLV-1 tax gene
38. Cellular transformation by human T-cell leukemia virus type 1
39. Activation of NF-kappa B by the Tax protein of HTLV-1
40. Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: Hijacking cellular IkappaB kinases
41. Regulation of NF-kappaB by the HTLV-1 Tax protein
42. Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B
43. Brain tumours and lymphomas in transgenic mice that carry HTLV-1 LTR/c-myc and Ig/tax genes
44. Pathogenesis of HIV and SIV
45. Human immunodeficiency virus activates c-myc and Epstein-Barr virus in human B lymphocytes
46. Common mechanisms for the control of eukaryotic transcriptional elongation
47. Nucleotide sequence analysis of the proviral genome of avian myelocytomatosis virus (MC29)
48. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis
49. Protein stabilization: A common consequence of mutations in independently derived v-Myc alleles
50. Retroviral Pathogenesis
51. Analysis of avian leukosis virus DNA and RNA in bursal tumours: Viral gene. expression is not required for maintenance of the tumor state
52. The molecular genetics of cancer
53. The molecular genetics of cellular oncogenes
54. Pathogenesis of retrovirus-induced disease
55. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites
56. Distribution of targets for avian retrovirus DNA integration in vivo
57. Transcriptional interaction between retroviral long terminal repeats (LTRs): Mechanism of 5′ LTR suppression and 3′ LTR promoter activation of c-myc in avian B-cell lymphomas
58. Differential transcription from the long terminal repeats of integrated avian leukosis virus DNA
59. Patterns of proviral insertion and deletion in avian leukosis virus-induced lymphomas
60. Tumorigenesis by slow-transforming retroviruses - An update
61. RAV-1 insertional mutagenesis: Disruption of the c-myb locus and development of avian B-cell lymphomas
62. c-erbB activation in avian leukosis virus-induced erythroblastosis: Clustered integration sites and the arrangement of provirus in the c-erbB alleles
63. c-erbB activation in ALV-induced erythroblastosis: Novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor
64. Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion
65. Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region
66. Involvement of c-myc in MuLV-induced T cell lymphomas in mice: Frequency and mechanisms of activation
67. Early clonality and high-frequency proviral integration into the c-myc locus in AKR leukemias
68. Deregulation of the c-myc oncogene in virus-induced thymic lymphomas of AKR/J mice
69. Viral integration near c-myc in 10-20% of mcf 247-induced AKR lymphomas
70. The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas
71. Selection for c-myc integration sites in polyclonal T-cell lymphomas
72. Identification of a region of a murine leukemia virus long terminal repeat with novel transcriptional regulatory activities
73. Common sites of viral integration in lymphomas arising in AKXD recombinant inbred mouse strains
74. Altered structure and expression of c-myc in feline T-cell tumours
75. Breakpoints in the human T-cell antigen receptor alpha-chain locus in two T-cell leukaemia patients with chromosomal translocations
76. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
77. Translocations among antibody genes in human cancer
78. Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma
79. Chromosomal approaches to the molecular basis of neoplasia
80. A 3′ truncation of myc caused by chromosomal translocation in a human T-cell leukemia is tumorigenic when tested in established rat fibroblasts
81. Integration of Friend murine leukemia virus into both alleles of the p53 oncogene in an erythroleukemic cell line
82. Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line
83. Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation
84. Acute myeloid leukemia induction by amphotropic murine retrovirus (4070A): Clonal integrations involve c-myb in some but not all leukemias
85. Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas
86. Activation of the Mlvi-1/mis1/pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas
87. Detection of myc translocations in lymphoma cells by fluorescence in situ hybridization with yeast artificial chromosomes
88. Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus
89. Expression of P0- and P3-RNA from the normal and translocated c-myc allele in Burkitt's lymphoma cells
90. The block of elongation in c-myc exon 1 is abolished in Burkitt's lymphoma cell lines with variant translocation
91. The v-myc oncogene
92. Myc function and regulation
93. Reversible tumorigenesis by MYC in hematopoietic lineages
94. Retroviral mutagenesis of cellular oncogenes: A review with insights into the mechanisms of insertional activation
95. Sequences responsible for erythroid and lymphoid leukemia in the long terminal repeats of Friend-mink cell focus-forming and Moloney murine leukemia viruses
96. Role for the 3′ end of the genome in determining disease specificity of Friend and Moloney murine leukemia viruses
97. Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences
98. Rearrangements of the Pim-1, c-myc, and p53 genes in Friend helper virus-induced mouse erythroleukemias
99. Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas
100. Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development
101. Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice
102. Type B leukemogenic virus has a T-cell-specific enhancer that binds AML-1
103. Novel leukaemogenic retroviruses isolated from cell line derived from spontaneous AKR tumour
104. B-cell lymphoma induction by Akv murine leukemia viruses harboring one or both copies of the tandem repeat in the U3 enhancer
105. Contributions to transcriptional activity and to viral leukemogenicity made by sequences within and downstream of the MCF13 murine leukemia virus enhancer
106. Role of the LTR region between the enhancer and promoter in mink cell focus-forming murine leukemia virus pathogenesis
107. Sequences between the enhancer and promoter in the long terminal repeat affect murine leukemia virus pathogenicity and replication in the thymus
108. Sequence-specific and/or stereospecific constraints of the U3 enhancer elements of MCF 247-W are important for pathogenicity
109. Long terminal repeat enhancer core sequences in proviruses adjacent to c-myc in T-cell lymphomas induced by a murine retrovirus
110. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
111. Runt domain factor (Runx)-dependent effects on CCAAT/enhancer-binding protein delta expression and activity in osteoblasts
112. Sequence specificity of the core-binding factor
113. Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1
114. Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3
115. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
116. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
117. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha
118. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
119. Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity
120. Transcriptional activity of core binding factor-alpha (AML 1) and beta sub-units on murine leukemia virus enhancer cores
121. Suppressor mutations within the core binding factor (CBF/AML 1) binding site of a T-cell lymphomagenic retrovirus
122. Selection of reversions and suppressors of a mutation in the CBF binding site of a lymphomagenic retrovirus
123. Core-binding factor influences the disease specificity of Moloney murine leukemia virus
124. Stability of AML 1 (core) site enhancer mutations in T lymphomas induced by attenuated SL3-3 murine leukemia virus mutants
125. Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2
126. Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1)
127. Importance of a c-Myb binding site for lymphomagenesis by the retrovirus SL3-3
128. Identification of nucleotide sequences that regulate transcription of the MCF13 murine leukemia virus long terminal repeat in activated T cells
129. Alterations in the U3 region of the long terminal repeat of an infectious thymotropic type B retrovirus
130. Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphomas
131. Lability of leukosis virus enhancer-binding proteins in avian hematopoeitic cells
132. a1/EBP: A leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer
133. Regulation of avian leukosis virus long terminal repeat-enhanced transcription by C/EBP-Rel interactions
134. The VBP and a1/EBP leucine zipper factors bind overlapping subsets of avian retroviral long terminal repeat CCAAT/enhancer elements
135. Retroviral enhancer insertion 5′ of c-myc in two translocation-negative mouse plasmacytomas upregulates c-myc expression to different extents
136. Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene
137. Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts
138. Retroviral insertional mutagenesis as a strategy to identify cancer genes
139. Identification and characterization of collaborating oncogenes in compound mutant mice
140. Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death
141. Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors
142. MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene
143. The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death
144. The role of apoptosis in regulating hematopoiesis and hematopoietic stem cells
145. Moloney murine leukemia virus infection accelerates lymphomagenesis in E mu-bcl-2 transgenic mice
146. Selective cooperation of HTLV-1-encoded p40tax-1 with cellular oncoproteins in the induction of hematopoietic cell proliferation
147. flvi-2, a target of retroviral insertional mutagenesis in feline thymic lymphosarcomas, encodes bmi-1
148. Insertional mutagenesis of flvi-2 in tumors induced by infection with LC-FeLV, a myc-containing strain of feline leukemia virus
149. HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties
150. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex
151. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
152. til-1: A novel proviral insertion locus for Moloney murine leukaemia virus in lymphomas of CD2-myc transgenic mice
153. A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc
154. Identification of murine CBF alpha1, a runt domain transcription factor, as a putative Myc collaborator in T cell lymphoma
155. Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex
156. Retroviral infection accelerates T lymphomagenesis in E mu-N-ras transgenic mice by activating c-myc or N-myc
157. Cooperation of Myb and Myc proteins in T cell lymphomagenesis
158. Proviral activation of the c-myb proto-oncogene is detectable in preleukemic mice infected neonatally with Moloney murine leukemia virus but not in resulting end stage T lymphomas
159. The fit-1 common integration locus in human and mouse is closely linked to MYB
160. Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis
161. Lineage commitment in lymphopoiesis
162. A full-length Notch1 allele is dispensable for transformation associated with a provirally activated truncated Notch1 allele in Moloney MuLV-infected MMTV(D)/myc transgenic mice
163. Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice
164. A retrovirus that expresses v-abl and c-myc oncogenes rapidly induces plasmacytomas
165. Addition of constitutive c-myc expression to Abelson murine leukemia virus changes the phenotype of the cells transformed by the virus from pre-B-cell lymphomas to plasmacytomas
166. Recurring proviral integration suggests a role for protooncogene activation in thymomas induced with Mo-MuLV-rescued BCR/ABL virus
167. Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase
168. Moloney virus induction of T-cell lymphomas in a plasmacytomagenic strain of E mu-v-abl transgenic mice
169. Oncogene cooperation in lymphocyte transformation: Malignant conversion of E mu-myc transgenic pre-B cells in vitro is enhanced by v-H-ras or v-raf but not v-abl
170. Abelson virus potentiates long-term growth of mature B lymphocytes
171. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging
172. Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas
173. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
174. Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway
175. Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2
176. Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas
177. Zinc finger protein GFI-1 cooperates with myc and pim-1 in T cell lymphomagenesis
178. Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally
179. E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice
180. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase
181. Characterization of pal1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice
182. Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 trangenic mice require the Bmi1 RING finger
183. Traps to catch unwary oncogenes
184. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor
185. Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging
186. Pim-1 kinase and p100 cooperate to enhance c-Myb activity
187. Translocation (1;6)(p12;p23) in ANLL
188. BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas
189. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation
190. Relationship between the c-myb locus and the 6q-chromosomal aberration in leukemias and lymphomas
191. Chronic myelogenous leukemia: Biology and therapy
192. Analysis of the modulation of transcriptional activity in myelopoiesis and leukemogenesis
193. Linking Notch signaling, chromatin remodeling, and T-cell leukemogenesis